Results 51 to 60 of about 218,364 (416)
Alzheimer’s Disease and Impaired Bone Microarchitecture, Regeneration and Potential Genetic Links
Life, 2023 Alzheimer’s Disease (AD) and osteoporosis are both age-related degenerative diseases. Many studies indicate that these two diseases share common pathogenesis mechanisms.
Min Zhang, Shunze Hu, Xuying Sun
doaj +1 more source
Identification of atropine-and P2X1 receptor antagonist-reistant, neurogenic contractions of the urinary bladder [PDF]
, 2007 Acetylcholine and ATP are excitatory cotransmitters in parasympathetic nerves. We used P2X1 receptor antagonists to further characterize the purinergic component of neurotransmission in isolated detrusor muscle of guinea pig urinary bladder.
Gallagher, Gemma +3 more
core +1 more source
Cells, 2023 V-ATPase is an important factor in synaptic vesicle acidification and is implicated in synaptic transmission. Rotation in the extra-membranous V1 sector drives proton transfer through the membrane-embedded multi-subunit V0 sector of the V-ATPase.
Christian Lévêque +11 more
doaj +1 more source
eLife, 2023 We still face fundamental gaps in understanding how molecular plastic changes of synapses intersect with circuit operation to define behavioral states. Here, we show that an antagonism between two conserved regulatory proteins, Spinophilin (Spn) and Syd ...
Niraja Ramesh +6 more
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Imaging neurotransmitter transport in live cells with stimulated Raman scattering microscopy [PDF]
arXiv, 2022 Chemical neurotransmission is central to neurotypical brain function but also implicated in a variety of psychiatric neurodegenerative diseases. The release dynamics of neurotransmitters is correlated with but distinct from neuronal electrical signal propagation.
arxiv
Journal of Neuroscience, 1997 Subanesthetic doses of ketamine, a noncompetitive NMDA receptor antagonist, impair prefrontal cortex (PFC) function in the rat and produce symptoms in humans similar to those observed in schizophrenia and dissociative states, including impaired ...
B. Moghaddam +3 more
semanticscholar +1 more source
Role of the UNC13 family in human diseases: A literature review
AIMS Neuroscience, 2023 This literature review explores the pivotal roles of the Uncoordinated-13 (UNC13) protein family, encompassing UNC13A, UNC13B, UNC13C, and UNC13D, in the pathogenesis of various human diseases.
Ubaid Ansari +9 more
doaj +1 more source
Partial mean-field model for neurotransmission dynamics [PDF]
arXiv, 2023 This article addresses reaction networks in which spatial and stochastic effects are of crucial importance. For such systems, particle-based models allow us to describe all microscopic details with high accuracy. However, they suffer from computational inefficiency if particle numbers and density get too large.
arxiv
Neuron, 2019 The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability but how they regulate ATP synthesis as fuel conditions vary is unknown. We show that synapses can
Ghazaleh Ashrafi +3 more
semanticscholar +1 more source
Differential Myosin 5a splice variants in innervation of pelvic organs
Frontiers in Physiology, 2023 Introduction: Myosin proteins interact with filamentous actin and translate the chemical energy generated by ATP hydrolysis into a wide variety of mechanical functions in all cell types. The classic function of conventional myosins is mediation of muscle
Josephine A. Carew +10 more
doaj +1 more source