Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors [PDF]
, 2010 The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse.
A Dzung Lê +86 more
core +3 more sources
Activity-dependent modulation of neural circuit synaptic connectivity
Frontiers in Molecular Neuroscience, 2009 In many nervous systems, the establishment of neural circuits is known to proceed via a two-stage process; 1) early, activity-independent wiring to produce a rough map characterized by excessive synaptic connections, and 2) subsequent, use-dependent
Charles R Tessier, Kendal Broadie
doaj +1 more source
Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray [PDF]
, 2017 The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
Bruchas, Michael R +7 more
core +2 more sources
Using the maternal immune stimulation model of schizophrenia to investigate the therapeutic efficacy of neuromodulation techniques [PDF]
, 2020 The present work used a neurodevelopmental rodent model of schizophrenia, namely the maternal immune stimulation (MIS) model, to study the potency of electrical neuromodulation techniques to ameliorate and even prevent schizophrenia-relevant behavioral ...
Hadar, Ravit
core +1 more source
Neuron, 2019 The brain is a vulnerable metabolic organ and must adapt to different fuel conditions to sustain function. Nerve terminals are a locus of this vulnerability but how they regulate ATP synthesis as fuel conditions vary is unknown. We show that synapses can
Ghazaleh Ashrafi +3 more
semanticscholar +1 more source
Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication
Frontiers in Neuroscience, 2019 Based on the concept of the tripartite synapse, we have reviewed the role of glucose-derived compounds in glycolytic pathways in astroglial cells.
Carlos-Alberto Gonçalves +7 more
doaj +1 more source
Ionizing radiation alters functional neurotransmission in Drosophila larvae
Frontiers in Cellular Neuroscience, 2023 IntroductionPatients undergoing cranial ionizing radiation therapy for brain malignancies are at increased risk of long-term neurocognitive decline, which is poorly understood and currently untreatable.
Yi Zhang +12 more
doaj +1 more source
TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson’s Disease
International Journal of Molecular Sciences, 2020 γ-Aminobutiryc acid (GABA) is found extensively in different brain nuclei, including parts involved in Parkinson’s disease (PD), such as the basal ganglia and hippocampus.
María Dolores Muñoz +2 more
semanticscholar +1 more source
Effects of methamphetamine on locomotor activity and thalamic gene expression in leptin-deficient obese mice [PDF]
, 2017 Leptin is an adipose-derived hormone that regulates energy balance. Leptin receptors are expressed in extrahypothalamic sites and several reports showed that leptin can influence feeding and locomotor behavior via direct actions on dopaminergic neurons ...
Bisagno, Veronica +3 more
core +2 more sources
Corticosterone Acts in the Nucleus Accumbens to Enhance Dopamine Signaling and Potentiate Reinstatement of Cocaine Seeking [PDF]
, 2013 Stressful life events are important contributors to relapse in recovering cocaine addicts, but the mechanisms by which they influence motivational systems are poorly understood.
Baker, David A. +10 more
core +2 more sources