Results 81 to 90 of about 218,364 (416)

Roles for Mitochondrial Complex I Subunits in Regulating Synaptic Transmission and Growth

Frontiers in Neuroscience, 2022
To identify conserved components of synapse function that are also associated with human diseases, we conducted a genetic screen. We used the Drosophila melanogaster neuromuscular junction (NMJ) as a model. We employed RNA interference (RNAi) on selected
Bhagaban Mallik, C. Andrew Frank, C. Andrew Frank   +2 more
doaj   +1 more source

Glycine receptor autoantibodies disrupt inhibitory neurotransmission

Brain : a journal of neurology, 2019
Immunoglobulin G autoantibodies to glycine receptors are found in many patients with progressive encephalomyelitis with rigidity and myoclonus (PERM). Crisp et al.
S. Crisp, C. Dixon, L. Jacobson, E. Chabrol, S. Irani, M. Leite, G. Leschziner, Guy Leschziner, S. Slaght, A. Vincent, A. Vincent, D. Kullmann   +11 more
semanticscholar   +1 more source

The NMDA receptor GluN2C subunit controls cortical excitatoryinhibitory balance, neuronal oscillations and cognitive function [PDF]

, 2016
Despite strong evidence for NMDA receptor (NMDAR) hypofunction as an underlying factor for cognitive disorders, the precise roles of various NMDAR subtypes remains unknown.
Dravid, Shashank M., Gandhi, Pauravi J., Gupta, Subhash C., Hillman, Brandon G., Li, Ming, Liu, Jinxu, Mao, Zhihao, Monaghan, Daniel T., Pavuluri, Ratnamala, Ravikrishnan, Aparna, Stairs, Dustin J., Ugale, Rajesh R.   +11 more
core   +3 more sources

Multielement Filament Memristor Enabling Multifunctional Neuromorphic Device

Advanced Functional Materials, EarlyView.
A new type of memristor featuring a hybrid mechanism and multifunctional applications is introduced. The proposed single device combines the alloy metal filament with the oxygen vacancy filament to achieve both resistive and threshold switching with enhanced reliability, mimicking both biological synapses and nociceptors. This study shows that filament‐
Mingu Jang, Hanchan Song, Hae Jin Kim, Jung Ho Yoon, Kyung Min Kim   +4 more
wiley   +1 more source

Glycolysis-Derived Compounds From Astrocytes That Modulate Synaptic Communication

Frontiers in Neuroscience, 2019
Based on the concept of the tripartite synapse, we have reviewed the role of glucose-derived compounds in glycolytic pathways in astroglial cells.
Carlos-Alberto Gonçalves, Letícia Rodrigues, Larissa D. Bobermin, Caroline Zanotto, Adriana Vizuete, André Quincozes-Santos, Diogo O. Souza, Marina C. Leite   +7 more
doaj   +1 more source

Regulation of NMDA Receptor Signaling at Single Synapses by Human Anti-NMDA Receptor Antibodies

Frontiers in Molecular Neuroscience, 2022
The NMDA receptor (NMDAR) subunit GluN1 is critical for receptor function and plays a pivotal role in synaptic plasticity. Mounting evidence has shown that pathogenic autoantibody targeting of the GluN1 subunit of NMDARs, as in anti-NMDAR encephalitis ...
Charles A. Dean, Sarah R. Metzbower, Scott K. Dessain, Thomas A. Blanpied, David R. Benavides   +4 more
doaj   +1 more source

Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray [PDF]

, 2017
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain modulatory system and is a crucial site for opioid-induced analgesia. A number of previous studies have demonstrated that glutamate and GABA play critical opposing roles in
Bruchas, Michael R, Copits, Bryan A, Gereau, Robert W, IV, Gomez, Adrian M, Grajales-Reyes, Jose G, O\u27Brien, Daniel E, Samineni, Vijay K, Trigg, Sarah L   +7 more
core   +2 more sources

A Multimodal Humidity Adaptive Optical Neuron Based on a MoWS2/VOx Heterojunction for Vision and Respiratory Functions

Advanced Materials, EarlyView.
A multifunctional memristor is demonstrated for in‐memory sensing and computing, leveraging a MoWS₂/VOx heterojunction to enable high ON/OFF ratio up to 10⁸ with ultralow operating voltages of ±0.2 V. This bio‐inspired multimodal design exhibits tunable synaptic behavior across electrical, optical, and humidity stimuli, enabling in situ modulation of ...
Abdul Momin Syed, Dhananjay D. Kumbhar, Hanrui Li, Manoj Kumar Rajbhar, Dayanand Kumar, Pratibha Pal, Nimer Wehbe, Mohamed ben Hassine, Nazek El‐Atab   +8 more
wiley   +1 more source

REDUCING PERIPHERAL INFLAMMATION WITH INFLIXIMAB REDUCES NEUROINFLAMMATION AND IMPROVES COGNITION IN RATS WITH HEPATIC ENCEPHALOPATHY

Frontiers in Molecular Neuroscience, 2016
Inflammation contributes to cognitive impairment in patients with hepatic encephalopathy (HE). However, the process by which peripheral inflammation results in cognitive impairment remains unclear.
Vicente Felipo
doaj   +1 more source

External Electromagnetic Wave Excitation of a PreSynaptic Neuron Based on LIF model [PDF]

arXiv, 2020
Interaction of electromagnetic (EM) waves with human tissue has been a longstanding research topic for electrical and biomedical engineers. However, few numbers of publications discuss the impacts of external EM-waves on neural stimulation and communication through the nervous system.
arxiv