Results 81 to 90 of about 229,968 (342)

Snake and spider toxins induce a rapid recovery of function of botulinum neurotoxin paralysed neuromuscular junction [PDF]

open access: yes, 2015
Botulinum neurotoxins (BoNTs) and some animal neurotoxins (-Bungarotoxin, -Btx, from elapid snakes and -Latrotoxin, -Ltx, from black widow spiders) are pre-synaptic neurotoxins that paralyse motor axon terminals with similar clinical outcomes in patients.
Duregotti, Elisa   +6 more
core   +2 more sources

Critical role of glutamatergic and GABAergic neurotransmission in the central mechanisms of theta‐burst stimulation

open access: yesHuman Brain Mapping, 2019
Theta‐burst stimulation (TBS) is a varied form of repetitive transcranial magnetic stimulation (rTMS) and has more rapid and powerful effects than rTMS.
Cheng-Ta Li   +5 more
semanticscholar   +1 more source

Carbon Quantum Dots Assisted Virus Tracking: From Skin to Brain

open access: yesAdvanced Materials, EarlyView.
A novel carbon quantum dots‐dissolvable microneedle, CQDs‐dMN system, enables painless delivery and real‐time tracking of HSV‐1. The HSV‐1 is labeled with fluorescent CQDs and delivered to the skin dermis, minimizing damage compared to traditional methods.
Yaxiu Feng   +11 more
wiley   +1 more source

Tryptophan research in panic disorder. [PDF]

open access: yes, 2008
A considerable body of evidence suggests the involvement of serotonin neurotransmission in the pathogenesis of panic disorder. Research on pathways and functions of tryptophan, an essential amino acid converted into serotonin, may advance our ...
Maron, E, Nutt, DJ, Shlik, J
core   +5 more sources

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li   +14 more
wiley   +1 more source

Glycine receptor autoantibodies disrupt inhibitory neurotransmission

open access: yesBrain : a journal of neurology, 2019
Immunoglobulin G autoantibodies to glycine receptors are found in many patients with progressive encephalomyelitis with rigidity and myoclonus (PERM). Crisp et al.
S. Crisp   +11 more
semanticscholar   +1 more source

Cortico‐Striatal‐Midbrain Circuit Dysregulation Underlying MK‐801 Induced Impulsivity and the Ameliorative Effects of SEP

open access: yesAdvanced Science, EarlyView.
Impulsivity is a symptom across multiple psychiatric disorders, yet its neural basis remains elusive. This study shows that the NMDAR antagonist MK‐801 elevates dopamine release and disrupts neuronal selectivity in the nucleus accumbens, leading to impulsive behavior.
Xueru Wang   +6 more
wiley   +1 more source

Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling

open access: yesFrontiers in Cellular and Infection Microbiology, 2019
Toxoplasma gondii is a widespread obligate intracellular parasite that causes chronic infection and life-threatening acute infection in the central nervous system.
Amol K. Bhandage   +2 more
doaj   +1 more source

Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms

open access: yesLipids in Health and Disease, 2020
Background Schizophrenia is a serious long-term psychotic disorder marked by positive and negative symptoms, severe behavioral problems and cognitive function deficits.
Mei-Chi Hsu   +2 more
doaj   +1 more source

Fluorescent Biosensors for Neurotransmission and Neuromodulation: Engineering and Applications

open access: yesFrontiers in Cellular Neuroscience, 2019
Understanding how neuronal activity patterns in the brain correlate with complex behavior is one of the primary goals of modern neuroscience. Chemical transmission is the major way of communication between neurons, however, traditional methods of ...
A. Leopold   +2 more
semanticscholar   +1 more source

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