Results 81 to 90 of about 191,466 (342)

Regulating PPARG Reduces Lipid Accumulation in Microglia and Promotes Functional Recovery After Spinal Cord Injury

Advanced Science, EarlyView.
Macrophages infiltrate the spinal cord post‐injury, decreasing over time. Microglia phagocytose myelin debris, increasing lipid accumulation. Macrophage deletion improves outcomes, while microglial deletion worsens them. The LD+ microglia subtype shows abnormal Pparg signaling.
Mingran Luo, Jiayun Liu, Yunxin Su, Tao Jiang, Xincan Wu, Peng Gao, Tao Qin, Mengyuan Wu, Qingqing Li, Shujun Zhang, Baorong He, Yongxiang Wang, Xiaodong Guo, Wei Zhou, Shujie Zhao, Jin Fan, Jian Chen, Guoyong Yin   +17 more
wiley   +1 more source

Aluminum Exposure Impairs Electrochemically Measured Vesicular Storage and Exocytosis via Iron Homeostasis Dysregulation

Angewandte Chemie, EarlyView.
Al3+ competes with Fe3+ for transferrin (Tf) binding and enters cells via transferrin receptor (TfR)‐mediated endocytosis, disrupting cellular iron homeostasis. Intracellular vesicle impact electrochemical cytometry (IVIEC) and single‐cell amperometry (SCA), which record the oxidation of dopamine, reveal increased neurotransmitter storage and ...
Shi‐Hua Chen, Chaoyi Gu, Xing‐Jiu Huang, Andrew G. Ewing   +3 more
wiley   +2 more sources

The effects of whole-body vibration therapy on immune and brain functioning: current insights in the underlying cellular and molecular mechanisms

Frontiers in Neurology
Whole-body vibration (WBV) therapy is a way of passive exercise in which subjects are exposed to mild and well-controlled mechanical vibrations through a vibrating platform.
Gargi Ahuja, Gargi Ahuja, Y. Laurisa Arenales Arauz, Y. Laurisa Arenales Arauz, Marieke J. G. van Heuvelen, Arjan Kortholt, Tamás Oroszi, Eddy A. van der Zee   +7 more
doaj   +1 more source

Brain serotonin synthesis capacity in obsessive-compulsive disorder: effects of cognitive behavioral therapy and sertraline. [PDF]

, 2018
Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these ...
Barsoum, Amir, Benkelfat, Chawki, Berney, Alexandre, Cottraux, Jean, Diksic, Mirko, Gravel, Paul, Leyton, Marco, Lissemore, Jennifer I, Nordahl, Thomas E, Pinard, Gilbert, Sibon, Igor, Sookman, Debbie   +11 more
core   +2 more sources

Allele‐Specific Regulation of PAXIP1‐AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice

Advanced Science, EarlyView.
This study identifies a functional noncoding variant, rs112651172 (C/G), that drives allele‐specific expression of PAXIP1‐AS1 in monozygotic twin pairs discordant for schizophrenia and bipolar disorder. The risk G allele enhances CEBPB binding, leading to lncRNA upregulation, CNTNAP3 derepression, and synaptic and behavioral deficits in mice.
Chaoying Ni, He Chen, Qiaqi Chen, Yangyang Liao, Yunqian Wang, Linyan Ye, Xiaohui Wu, Hongyu Ni, Tingyun Jiang, Shufen Li, Qiong Yang, Hong Xue, Zhongju Wang, Feng Yi, Cunyou Zhao   +14 more
wiley   +1 more source

Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms

Lipids in Health and Disease, 2020
Background Schizophrenia is a serious long-term psychotic disorder marked by positive and negative symptoms, severe behavioral problems and cognitive function deficits.
Mei-Chi Hsu, Yung-Sheng Huang, Wen-Chen Ouyang   +2 more
doaj   +1 more source

Novel Optoelectronic Reconfigurable Transistors Based on Graphene/VO2 Heterojunction for Efficient Neuromorphic Perception, Computation, and Storage

Advanced Science, EarlyView.
A novel optoelectronic reconfigurable neuromorphic transistor based on a graphene/VO2 heterojunction with inserted Au electrodes is proposed. It exhibits broad‐spectrum self‐powered photodetection capability ranging from 365 to 940 nm. Through bias control and electrode sizing strategies, multiple functions for switch, synapse, and storage are achieved,
Danke Chen, Yuning Li, Xiaoqiu Tang, Jingye Sun, Xuan Yao, Peizhi Yu, Xue Li, Qing You, Hanyu Wang, He Tian, Tao Deng   +10 more
wiley   +1 more source

Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy

Frontiers in Neurology, 2020
Seizures often exhibit striking circadian-like (~24-h) rhythms. While chronotherapy has shown promise in treating epilepsy, it is not widely used, in part because the patterns of seizure rhythmicity vary considerably among patients and types of epilepsy.
Mani Ratnesh S. Sandhu, Roni Dhaher, Shaun E. Gruenbaum, Raaisa Raaisa, Dennis D. Spencer, Milena K. Pavlova, Hitten P. Zaveri, Tore Eid   +7 more
doaj   +1 more source

Enhanced Protein Synthesis and Hippocampus‐Dependent Memory via Inhibition of YTHDF2‐Mediated m6A mRNA Degradation

Advanced Science, EarlyView.
YTHDF2‐mediated m6A mRNA decay critically regulates learning and memory. Its forebrain‐specific knockout in mice impedes degradation of m6A‐modified mRNAs, enhancing hippocampal synaptic transmission, protein synthesis, and memory. Conversely, hippocampal YTHDF2 reintroduction or SEMA4B reduction reverses this enhancement, while its overexpression ...
Kuan Li, Chen Guo, Xiaoli Wu, Cuiting Wu, Songfen Wu, Si Su, Min Wu, Xidan Zhou, Si Li, Yihui Cui, Tao Zhou   +10 more
wiley   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source