Results 101 to 110 of about 170,105 (313)
From metabolism to mind: The expanding role of the GLP-1 receptor in neurotherapeutics
NeurotherapeuticsGLP-1 receptor agonists (GLP-1RAs), initially approved for diabetes and obesity, are now under investigation for neuroprotective effects in a range of neurological disorders. These agents, whose receptors are widely expressed in brain regions involved in
Akash Roy +2 more
doaj +1 more source
A Renal Clearable Probe for In Vivo Monoamine Oxidase (MAO) Detection
Advanced Science, EarlyView.A renal‐clearable Cy7‐based fluorogenic probe enables rapid and non‐invasive detection of monoamine oxidase (MAO) activity in vivo. Upon MAO‐mediated activation, the fluorescent product is efficiently excreted in urine, allowing direct quantification of enzyme overexpression.
Marcia Domínguez +13 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo +13 more
wiley +1 more source
GABA_{B} Receptors Regulate Chick Retinal Calcium Waves [PDF]
, 2001 Correlated spiking activity and associated Ca²⁺ waves in the developing retina are important in determining the connectivity of the visual system. Here, we show that GABA, via GABA_{B} receptors, regulates the temporal characteristics of Ca²⁺ waves ...
Catsicas, M, Mobbs, P
core
Advanced Science, EarlyView.A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An +8 more
wiley +1 more source
Advanced Science, EarlyView.This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han +5 more
wiley +1 more source
KInNeSS: A Modular Framework for Computational Neuroscience [PDF]
, 2007 Making use of very detailed neurophysiological, anatomical, and behavioral data to build biological-realistic computational models of animal behavior is often a difficult task.
Ames, Heather +4 more
core +2 more sources
Hypocretin neurotransmitter system and narcolepsy [PDF]
Vojnosanitetski Pregled, 2008 Lakočević Milan B., Rajšić Nenad R.
doaj +1 more source
Sensors, 2013 The enzyme acetylcholinesterase (AChE) is an important part of cholinergic nervous system, where it stops neurotransmission by hydrolysis of the neurotransmitter acetylcholine.
Rene Kizek +2 more
doaj +1 more source
Polyelectrolyte Design Principles for Electrophoretic Drug Delivery
Advanced Science, EarlyView.Structure–property–function mapping of polyelectrolytes reveals how composition and nanoscale order control on‐demand electrophoretic drug transport. Charge density quantified under implant‐relevant conditions shows that encapsulation limits swelling, enabling high effective charge density.
Helena Saarela Unemo +8 more
wiley +1 more source