Results 191 to 200 of about 156,401 (247)
Neurochemistry International, 1998 The purpose of this study is to determine whether differences in membrane potential and/or intracellular Ca2+ increments are implicated in a programmed release of amino acid neurotransmitters (aspartate, glutamate, glycine and GABA) in cortical neurons in culture.
Miguel Herrero +4 more
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Journal of Neurochemistry, 1976 Abstract— The effects of 121 mm‐K+, 10 mm‐glutamate, 5 mm‐GABA, 1 mm‐glycine, 0.1 mm‐NE, and 1–10 μmACh on cyclic GMP levels in tissue slices prepared from cerebral cortex and cerebellum of mouse, rabbit, guinea‐pig, cat, and rat were studied. Basal levels of cyclic GMP in the cerebella of mice, guinea‐pigs and cats were 4–15 and 70 pmol/mg prot in rat,
Dorothy A. Kinscherf +4 more
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Neurochemistry International, 2001 Although numerous biochemical and electrophysiological studies have already established many of the properties of the putative Ca2+ receptor for exocytosis at the synapse, the molecular mechanism that involves the influx of Ca2+ and the release of neurotransmitters has remained elusive.
Edith López +4 more
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Journal of Molecular Structure: THEOCHEM, 2003 Abstract Recent insight has implicated the formation of β-amyloid fibril formation as a culpable process for the progression of Alzheimer's disease. Amyloid-β (Aβ) is a peptide naturally secreted by neurons in a random coil structure. It has been deduced that a conformational transition from a random coil to a β-pleated sheet is responsible for Aβ's ...
Luca F. Pisterzi +6 more
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Mini-Reviews in Medicinal Chemistry, 2008 Gamma hydroxybutyric acid (GHB), an endogenous constituent of the mammalian brain, acts as i) a neurotransmitter or neuromodulator, ii) a medicine used for the treatment of narcolepsy and alcoholism, and iii) a drug illicitly used for its psychotropic effects. GHB is thought to act as a specific GHB receptor agonist as well as a weak gamma-aminobutyric
Paola Castelli
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Neuropharmacology, 1985 The effects of atropine (5 mg/kg), baclofen (10 mg/kg), gamma-hydroxybutyrate (300 mg/kg), gamma-butyrolactone (100 mg/kg) and muscimol (1 mg/kg) upon the action of 2-amino-5-phosphonovalerate (APV; an antagonist at receptors for N-methyl-D-aspartate) on the threshold current for seizures induced by electroshock, were studied in mice.
Stanisław J. Czuczwar +4 more
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Development of anti-obesity agents: drugs that target neuropeptide and neurotransmitter systems
Expert Opinion on Investigational Drugs, 2008 Obesity results from an imbalance of energy intake and energy expenditure. While the prevalence of obesity is increasing and the negative impact on public health is being recognized, highly effective and safe therapy for obesity is not yet available.This review summarizes the current state of the art in the late-stage development area of anti-obesity ...
Tung M. Fong
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Neuroendocrinology, 1974 The injection into the 3rd ventricle of betha-nechol, carbachol and noradrenaline provoked the release of antidiuretic hormone (ADH) in the hydrated male rat, as indicated by a decrease in urine flow and free-water clearance, with an increased urinary electrolyte concentration, osmolality and conductivity.
E.R. K uuml hn
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CENTRAL NEUROTRANSMITTERS AND ANAESTHETIC AGENTS
Proceedings of the Association of Veterinary Anaesthetists, 1980 David Lodge
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General Pharmacology: The Vascular System, 1989 1. The comparative effects of verapamil and D-600, on isometric contractions produced by noradrenaline, acetylcholine, phenylephrine, clonidine, carbachol and high potassium, were studied in rat isolated seminal vesicle. 2. The aim was to see if verapamil and D-600 differed, in their selectivity, of blocking calcium, channels, and hence inhibition of ...
F. A. WALI, E. GREENIDGE
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