Results 191 to 200 of about 165,229 (327)

Real‐world efficacy and safety of cannabidiol in developmental and epileptic encephalopathies

Epilepsia Open, EarlyView.
Abstract Objective Highly purified cannabidiol (CBD) is approved as adjunctive therapy for seizures associated with Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), and tuberous sclerosis complex (TSC), although its role in other developmental and epileptic encephalopathies (DEEs) remains unexplored.
Marco Perulli, Maddalena Bianchetti, Gloria Pantalone, Michela Quintiliani, Maria Luigia Gambardella, Maria Picilli, Carla Marini, Elisabetta Cesaroni, Domenica Immacolata Battaglia   +8 more
wiley   +1 more source

Local activity alterations in individuals with autism correlate with neurotransmitter properties and ketamine-induced brain changes. [PDF]

Nat Commun
Grumbach P, Kasper J, Hipp JF, Forsyth A, Valk SL, Muthukumaraswamy S, Eickhoff SB, Schilbach L, Dukart J.   +8 more
europepmc   +1 more source

Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study

Epilepsia Open, EarlyView.
Abstract Objective Understanding the role of plasma proteins in the pathophysiology of epilepsy is crucial for uncovering novel biological mechanisms and therapeutic targets. Mendelian randomization (MR) provides a valuable tool for dissecting potentially causal associations between circulating proteins and disease risk.
Jingfeng Fu, Wei Wu, Shangren Shen
wiley   +1 more source

How a Medicinal Chemistry Project Changed the Way Prostate Cancer is Diagnosed and Treated. [PDF]

J Med Chem
Kozikowski AP, Neale J.
europepmc   +1 more source

Efficacy and Safety of Lisdexamfetamine Versus Topiramate Versus Naltrexone/Bupropion in Individuals With Binge Eating Disorder: A Network Meta‐Analysis

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of lisdexamfetamine, topiramate, and naltrexone/bupropion for treating binge eating disorder (BED) using network meta‐analysis. Method We systematically searched PubMed, Scopus, ClinicalTrials.gov, and Cochrane Central up to February 2025 for randomized controlled trials evaluating these medications
Tamer Hodrob, Ibrahim Ismail, Alaaeddin Abusalameh, Celina R. Andonie, Omar Ayesh, Hazem Ayesh   +5 more
wiley   +1 more source

Inflammatory links between epilepsy and depression: a review of mechanisms and therapeutic strategies. [PDF]

Front Neurosci
Shi YQ, Yang HC, He C, Wang YH, Zheng J, Wang XY, Hao FY, Feng CW, Ma L, Zhang YH, Liu Z.   +10 more
europepmc   +1 more source

The Impact of Lactobacillus paracasei subsp. Paracasei on Oxytetracycline‐Induced Anxiety‐Like Behavior of Zebrafish via Regulation of Gut Microbiota and Brain Fatty Acid Metabolism

Food Frontiers, EarlyView.
LPSP exhibited considerable potential in reversing OTC‐induced anxiety‐like behavior. Combined with gut microbiomics and metabolomics, we revealed the underlying mechanisms. ABSTRACT The use of oxytetracycline (OTC) in aquaculture is crucial for fish health and disease prevention, but it might accumulate in humans through the food chain, potentially ...
Yang Qiu, Jiaxin Guo, Jie Zhang, Chenxu Xue, Wanjun He, Zhenquan Huo, Jiajin Zhu   +6 more
wiley   +1 more source

Association of decreased thalamic neurotransmitter level with sensorimotor tract damage in patients with relapsing-remitting multiple sclerosis. [PDF]

Quant Imaging Med Surg
Xie Y, Ding Y, Wu S, Zhang Y, Zhu H, Li Y, Zhang X, Zhu W.   +7 more
europepmc   +1 more source

Fermentation‐Assisted Valorization: A Sustainable Strategy for Turning Fruit By‐Products Into Value‐Added Food Supplements

Food Frontiers, EarlyView.
ABSTRACT A substantial proportion of fresh fruit undergoes processing, resulting in underutilized fruit by‑products (FBPs) that are rich in dietary fiber and bioactive compounds. Recent FBP valorization trends demonstrate that fermentation significantly enhances microbiological, nutritional, and sensory attributes, yielding value‑added food supplements.
Abouzar Ghasemi, Salwa Karboune, Denis Groleau, Ismail Fliss   +3 more
wiley   +1 more source

Effects of microsurgery on short-term serum neurotransmitter levels and long-term cerebral neurological function in elderly patients with spontaneous intracerebral hemorrhage. [PDF]

Front Neurol
Zhang Y, Pan R, Liao Z, Yin S.
europepmc   +1 more source