Results 211 to 220 of about 3,509,514 (361)

Real‐world efficacy and safety of cannabidiol in developmental and epileptic encephalopathies

Epilepsia Open, EarlyView.
Abstract Objective Highly purified cannabidiol (CBD) is approved as adjunctive therapy for seizures associated with Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), and tuberous sclerosis complex (TSC), although its role in other developmental and epileptic encephalopathies (DEEs) remains unexplored.
Marco Perulli, Maddalena Bianchetti, Gloria Pantalone, Michela Quintiliani, Maria Luigia Gambardella, Maria Picilli, Carla Marini, Elisabetta Cesaroni, Domenica Immacolata Battaglia   +8 more
wiley   +1 more source

Circadian clock genes and insomnia: molecular mechanisms and therapeutic implications. [PDF]

Ann Med
Ren Q, Gu M, Fan X.
europepmc   +1 more source

Assessing the causal relationship between the plasma proteome and epilepsy: A Mendelian randomization study

Epilepsia Open, EarlyView.
Abstract Objective Understanding the role of plasma proteins in the pathophysiology of epilepsy is crucial for uncovering novel biological mechanisms and therapeutic targets. Mendelian randomization (MR) provides a valuable tool for dissecting potentially causal associations between circulating proteins and disease risk.
Jingfeng Fu, Wei Wu, Shangren Shen
wiley   +1 more source

Exploring how levetiracetam mitigates toxicity and ameliorates memory impairment. [PDF]

Front Pharmacol
Alhowail AH, Alharbi AM.
europepmc   +1 more source

Efficacy and Safety of Lisdexamfetamine Versus Topiramate Versus Naltrexone/Bupropion in Individuals With Binge Eating Disorder: A Network Meta‐Analysis

European Eating Disorders Review, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of lisdexamfetamine, topiramate, and naltrexone/bupropion for treating binge eating disorder (BED) using network meta‐analysis. Method We systematically searched PubMed, Scopus, ClinicalTrials.gov, and Cochrane Central up to February 2025 for randomized controlled trials evaluating these medications
Tamer Hodrob, Ibrahim Ismail, Alaaeddin Abusalameh, Celina R. Andonie, Omar Ayesh, Hazem Ayesh   +5 more
wiley   +1 more source

Phytochemical insights and neuro-gut axis modulation of <i>Asparagus racemosus</i> (Shatavari) in Postpartum Depression: a mini review with HPTLC-Based justification. [PDF]

Front Nutr
D D, Krishnarajabhatt HS, Unnikrishnan P.   +2 more
europepmc   +1 more source

Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process

Exploration, EarlyView.
Periosteum is a key factor in bone regeneration and repair, and the development of periosteum organoids with the help of organoid technology can achieve accelerated bone regeneration. This review explores the structure and function of the periosteum, the design and application of periosteum organoids, and their potential integration with bone organoids,
Shuyue Hao, Fuxiao Wang, Jingtao Huang, Zhidao Xia, James T. Triffitt, Chenjie Xu, Long Bai, Jiacan Su   +7 more
wiley   +1 more source

Evaluation of the antidepressant potential of Duloxetine, Coffea canephora, and Nigella sativa in a rat depression model. [PDF]

Metab Brain Dis
Abdel-Baky ES, Radwan SA, Abdelhamid FM, Abdelrhman ON.   +3 more
europepmc   +1 more source

Nutritional Value and Memory‐Improving Effects of Seven Major Nuts: A Comprehensive Study Using Network Pharmacology and In Vivo Assays

Food Frontiers, EarlyView.
This study highlights the memory‐enhancing effects of walnuts, almonds, and Torreya, with walnuts showing the strongest potential to improve cognitive function and delay brain aging. ABSTRACT This study explored the memory‐enhancing potential of seven commercially available nuts through nutritional profiling, metabolomics, network pharmacology, and ...
Jiamin Chen, Ben Niu, Ruiling Liu, Chaoyi Shen, Huizhi Chen, Mohamed A. Farag, Hangjun Chen, Qi Chen, Long Jin, Weijie Wu, Haiyan Gao   +10 more
wiley   +1 more source

Enteric nervous system as a therapeutic target in gastrointestinal disorders. [PDF]

World J Gastrointest Pharmacol Ther
Agrawal H, Agarwal N, Gupta N.
europepmc   +1 more source