Results 301 to 310 of about 3,535,923 (362)
Life Sciences, 1974 Abstract The effects of norepinephrine, other catecholamines, α- and β- adrenergic receptor blocking agents and acetylcholine on the incorporation of 32Pi into phospholipids of the iris muscle of the rabbit were studied in vitro . There was a marked stimulation of 32Pi into phosphatidic acid (PhA), phosphatidyl inositol (PhI) and to a much ...
Ata A. Abdel‐Latif
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Science of The Total Environment, 2020 Toxic agents such as pharmaceuticals and pesticides are continuously dispersed especially in the aquatic environment, as a result of human use. Their presence in the environment presents serious concerns, since these compounds interfere with the normal function of the central nervous system (CNS), causing behavior alterations, whose consequences are ...
Beatriz Sousa, Bruno Nunes
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Journal of Neurochemistry, 1976 Abstract— The effects of 121 mm‐K+, 10 mm‐glutamate, 5 mm‐GABA, 1 mm‐glycine, 0.1 mm‐NE, and 1–10 μmACh on cyclic GMP levels in tissue slices prepared from cerebral cortex and cerebellum of mouse, rabbit, guinea‐pig, cat, and rat were studied. Basal levels of cyclic GMP in the cerebella of mice, guinea‐pigs and cats were 4–15 and 70 pmol/mg prot in rat,
Dorothy A. Kinscherf +4 more
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Life Sciences, 2006 Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and sulindac, on rat liver TDO activity and
Amichand Dairam +3 more
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Neurochemistry International, 1998 The purpose of this study is to determine whether differences in membrane potential and/or intracellular Ca2+ increments are implicated in a programmed release of amino acid neurotransmitters (aspartate, glutamate, glycine and GABA) in cortical neurons in culture.
Miguel Herrero +4 more
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Journal of Neurochemistry, 1999
Abstract : GABA, which is present in the brain in large amounts, is distributed among distinctly different cellular pools, possibly reflecting its multiple functions as metabolite, neurotransmitter, and neurotrophin. Its metabolic enzymes also exhibit heterogeneity, because glutamate decarboxylase exists in two isoforms with different subcellular ...
H S, Waagepetersen +2 more
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Abstract : GABA, which is present in the brain in large amounts, is distributed among distinctly different cellular pools, possibly reflecting its multiple functions as metabolite, neurotransmitter, and neurotrophin. Its metabolic enzymes also exhibit heterogeneity, because glutamate decarboxylase exists in two isoforms with different subcellular ...
H S, Waagepetersen +2 more
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NeuroToxicology, 2018 Methylmercury (MeHg) is an environmental toxicant with detrimental effects on the developing brain and adult nervous system. The main mechanisms identified include oxidative stress, changes in intracellular calcium, mitochondrial changes, inhibition of glutamate uptake, of protein synthesis and disruption of microtubules. However, little is known about
Nair Olguín +3 more
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Development of anti-obesity agents: drugs that target neuropeptide and neurotransmitter systems
Expert Opinion on Investigational Drugs, 2008Obesity results from an imbalance of energy intake and energy expenditure. While the prevalence of obesity is increasing and the negative impact on public health is being recognized, highly effective and safe therapy for obesity is not yet available.This review summarizes the current state of the art in the late-stage development area of anti-obesity ...
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Neuropharmacology, 1985
The effects of atropine (5 mg/kg), baclofen (10 mg/kg), gamma-hydroxybutyrate (300 mg/kg), gamma-butyrolactone (100 mg/kg) and muscimol (1 mg/kg) upon the action of 2-amino-5-phosphonovalerate (APV; an antagonist at receptors for N-methyl-D-aspartate) on the threshold current for seizures induced by electroshock, were studied in mice.
S J, Czuczwar +4 more
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The effects of atropine (5 mg/kg), baclofen (10 mg/kg), gamma-hydroxybutyrate (300 mg/kg), gamma-butyrolactone (100 mg/kg) and muscimol (1 mg/kg) upon the action of 2-amino-5-phosphonovalerate (APV; an antagonist at receptors for N-methyl-D-aspartate) on the threshold current for seizures induced by electroshock, were studied in mice.
S J, Czuczwar +4 more
openaire +2 more sources