Results 71 to 80 of about 156,401 (247)

The binding of botulinum neurotoxins to different peripheral neurons [PDF]

, 2017
Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
core   +1 more source

In-vivo Magnetic Resonance Imaging of GABA and Glutamate [PDF]

arXiv, 2020
Chemical Exchange Saturation Transfer (CEST) Magnetic Resonance Imaging (MRI) is a molecular imaging methodology capable of mapping brain metabolites with relatively high spatial resolution. Specificity is the main goal of such experiments; yet CEST is confounded by spectral overlap between different molecular species.
arxiv  

The influence of anesthetics, neurotransmitters and antibiotics on the relaxation processes in lipid membranes [PDF]

J. Phys. Chem. B 111 (2007) 13858-13866, 2007
In the proximity of melting transitions of artificial and biological membranes fluctuations in enthalpy, area, volume and concentration are enhanced. This results in domain formation, changes of the elastic constants, changes in permeability and slowing down of relaxation processes. In this study we used pressure perturbation calorimetry to investigate
arxiv   +1 more source

Platelet Function in Mood Disorders: Interplay, Clinical Implications, and Future Perspectives – A Narrative Review

Heart and Mind
Mood disorders, encompassing major depressive disorder and bipolar disorder, present complex etiologies involving neuroanatomical, neurotransmitter, and inflammatory mechanisms.
Ni He, Hanxiu Liu, Jing Liu, Xiqiang Wang, Junkui Wang, Hengwei Xu, Zhongwei Liu   +6 more
doaj   +1 more source

Research Progress of PET Traces for Alzheimer’s Disease

Journal of Isotopes, 2014
Alzheimer’s disease (AD) is unknown cause progressive degenerative diseases of central nervous system. It is a serious threat to the health of the elderly people. The diagnosis is mainly based on pathological examination after death.
TANG Cai-hua1，2;HU Kong-zhen1;TANG Gang-hua1
doaj   +1 more source

A Targeted Therapeutic Rescues Botulinum Toxin-A Poisoned Neurons [PDF]

, 2008
Botulinum neurotoxin (BoNT), a Category A biothreat agent, is the most potent poison known to mankind. Currently no antidote is available to rescue poisoned synapses.
Bal Ram Singh, Dan Li, James Keller, Michael Adler, Peng Zhang, Prabhati Ray, Radharaman Ray   +6 more
core   +1 more source

Fluoxetine: a case history of its discovery and preclinical development [PDF]

, 2014
Introduction: Depression is a multifactorial mood disorder with a high prevalence worldwide. Until now, treatments for depression have focused on the inhibition of monoaminergic reuptake sites, which augment the bioavailability of monoamines in the CNS ...
Bel N, Bergstrom RF, Bravo L, Bremner JD, Burrows GD, Chouinard G, Datla KP, Esther Berrocoso, Juan Antonio Mico, Kreiss DS, Laura Perez-Caballero, Lemberger L, Li Q, Lidia Bravo, Maj J, Nibuya M, Owens MJ, Rutter JJ, Sonia Torres-Sanchez, Stevens JC, Wong DT   +20 more
core   +2 more sources

Monoamine neurotransmitters in breast cancer: Progression, immunomodulation, and therapeutic strategies [PDF]

Jorjani Biomedicine Journal
Monoamine neurotransmitters, including serotonin, dopamine, histamine, and adrenaline/noradrenaline (epinephrine/norepinephrine), are key neuromodulators in the nervous system that influence complex behavioral and cognitive functions.
Saeed Mahdianipur, Mahafarin Maralani, Homa Davoodi   +2 more
doaj  

Reliability of behavioral test with fish: How neurotransmitters may exert neuromodulatory effects and alter the biological responses to neuroactive agents

Science of The Total Environment, 2020
Toxic agents such as pharmaceuticals and pesticides are continuously dispersed especially in the aquatic environment, as a result of human use. Their presence in the environment presents serious concerns, since these compounds interfere with the normal function of the central nervous system (CNS), causing behavior alterations, whose consequences are ...
Sousa, Beatriz, Nunes, Bruno
openaire   +4 more sources

Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology [PDF]

, 2005
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur.
Bouzat, Cecilia Beatriz
core