Results 91 to 100 of about 44,677 (196)

Strategies to augment volitional and reflex function may improve locomotor capacity following incomplete spinal cord injury [PDF]

, 2018
Many studies highlight the remarkable plasticity demonstrated by spinal circuits following an incomplete spinal cord injury (SCI). Such plasticity can contribute to improvements in volitional motor recovery, such as walking function, although similar ...
Hornby, T. George, Kim, Hyosub E., Leech, Kristan A.   +2 more
core   +2 more sources

Activated CD8+ T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Cell Reports, 2019
Summary: Traumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged immune response in the brain may cause neurodegeneration, resulting in chronic neurological disturbances.
Maria Daglas, Dominik F. Draxler, Heidi Ho, Fiona McCutcheon, Adam Galle, Amanda E. Au, Pia Larsson, Julia Gregory, Frank Alderuccio, Maithili Sashindranath, Robert L. Medcalf   +10 more
doaj   +1 more source

Red Wine May Mitigate the Risk of Intracerebral Hemorrhage by Preventing Hypertension—A Mendelian Randomization Study Combining CHARLS

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study shows alcohol increases intracerebral hemorrhage risk (OR = 1.21), while red wine reduces it (two‐sample MR OR = 0.61; multivariable MR OR = 0.55), partly via lowering hypertension (mediation = 13.45%). CHARLS data find wine drinkers (especially elderly males) have lower hypertension (OR = 0.54), and this holds after multivariable logistic ...
Fuan Zhang, Ning Ding, Lanying Zhang, Ping Zhang, Rui Liu, Ziqiang Chen, Jiao Chen, Huanhuan Li, Shengtao Yao   +8 more
wiley   +1 more source

Mapping global evidence on strategies and interventions in neurotrauma and road traffic collisions prevention: a scoping review

Systematic Reviews, 2020
Background Neurotrauma is an important global health problem. The largest cause of neurotrauma worldwide is road traffic collisions (RTCs), particularly in low- and middle-income countries (LMICs).
Santhani M Selveindran, Tamara Tango, Muhammad Mukhtar Khan, Daniel Martin Simadibrata, Peter J. A. Hutchinson, Carol Brayne, Christine Hill, Franco Servadei, Angelos G. Kolias, Andres M. Rubiano, Alexis J. Joannides, Hamisi K. Shabani   +11 more
doaj   +1 more source

Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Cell Death Discovery
Intracerebral hemorrhage (ICH) is a devastating disease that disrupts the blood–brain barrier (BBB), triggers inflammation, and leads to subsequent neurological deficits.
Wenqianjun Sheng, Zhangyi Wu, Jingyan Wei, Jun Wang, Shengfan Zhang, Zhiquan Ding, Jinhao Zhong, Dexian Deng, Zhenzhong Zhong, Yunong Yin, Yulong Li, Qinghua Wang   +11 more
doaj   +1 more source

Astrocyte Transcriptomics in a Three-Dimensional Tissue-Engineered Rostral Migratory Stream

Cells
The glial tube is a longitudinal structure predominantly composed of densely bundled, aligned astrocytes that projects from the subventricular zone (SVZ) to the olfactory bulb. Neural precursor cells (NPCs) generated in the SVZ migrate through this glial
Michael R. Grovola, Erin M. Purvis, Andrés D. Garcia-Epelboim, Elizabeth N. Krizman, John C. O’Donnell, D. Kacy Cullen   +5 more
doaj   +1 more source

Prospects for mTOR-mediated functional repair after central nervous system trauma

Neurobiology of Disease, 2016
Recent research has suggested that the growth of central nervous system (CNS) axons during development is mediated through the PI3K/Akt/mammalian target of rapamycin (mTOR) intracellular signalling axis and that suppression of activity in this pathway ...
Martin Berry, Zubair Ahmed, Peter Morgan-Warren, Daniel Fulton, Ann Logan   +4 more
doaj   +1 more source

Clinical Correlates of High Cervical Fractional Anisotropy in Acute Cervical Spinal Cord Injury [PDF]

, 2015
Objective: Fractional anisotropy (FA) of the high cervical cord (C1-C2), rostral to the injury site, correlates with upper limb function in patients with chronic cervical spinal cord injury (SCI).
Eckardt, Gerald, Kurpad, Shekar N., Schmit, Brian D., Vedantam, Aditya, Wang, Marjorie C.   +4 more
core   +1 more source

Ten-year trends in traumatic brain injury: a retrospective cohort study of California emergency department and hospital revisits and readmissions. [PDF]

, 2018
OBJECTIVE:To describe visits and visit rates of adults presenting to emergency departments (EDs) with a diagnosis of traumatic brain injury (TBI). TBI is a major cause of death and disability in the USA; yet, current literature is limited because few ...
Guo, Joanna, Hsia, Renee Y, Lin, Feng, Madhok, Debbie Y, Manley, Geoffrey T, Markowitz, Amy J   +5 more
core   +1 more source

Surgical interventions for patients with spontaneous intracerebral haemorrhage: a systematic review and network meta-analysis

Stroke and Vascular Neurology
Background Intracerebral haemorrhage (ICH) is a critical condition that leads to significant mortality or profound disability. Surgery serves as an important intervention that can save lives; however, the surgical techniques employed globally exhibit ...
Chao Zhang, Long Wang, Yi Yin, Rong Hu, Yuhang Yang, Haomiao Wang, Dawei Zhao, Shuixian Zhang   +7 more
doaj   +1 more source