Results 41 to 50 of about 44,677 (196)

Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]

, 2019
Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi, Jin, Xiaoming, Qian, Jun, Wu, Wei, Xiong, Wenhui, Xu, Xiao-Ming   +5 more
core   +1 more source

Secondary Mechanisms of Neurotrauma: A Closer Look at the Evidence

Diseases, 2022
Traumatic central nervous system injury is a leading cause of neurological injury worldwide. While initial neuroresuscitative efforts are focused on ameliorating the effects of primary injury through patient stabilization, secondary injury in neurotrauma
Sina Aghili-Mehrizi, Eric Williams, Sandra Yan, Matthew Willman, Jonathan Willman, Brandon Lucke-Wold   +5 more
doaj   +1 more source

Nociceptive neuropeptide increases and periorbital allodynia in a model of traumatic brain injury. [PDF]

, 2012
OBJECTIVE: This study tests the hypothesis that injury to the somatosensory cortex is associated with periorbital allodynia and increases in nociceptive neuropeptides in the brainstem in a mouse model of controlled cortical impact (CCI) injury.
Amenta, Peter S., Awe, Olatilewa, Elliott, Melanie B., Jallo, Jack I., Oshinsky, Michael L.   +4 more
core   +2 more sources

Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury. [PDF]

, 2020
Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the ...
Aldrich, Christina, Eisenberg, Howard M, Hayman, Erik G, He, Feng, Jain, Sonia, Okonkwo, David O, Pasternak, Ofer, Shenton, Martha E, Simard, J Marc   +8 more
core  

Association of Blood Biomarkers With Acute Sport-Related Concussion in Collegiate Athletes: Findings From the NCAA and Department of Defense CARE Consortium [PDF]

, 2020
Importance: There is potential scientific and clinical value in validation of objective biomarkers for sport-related concussion (SRC). Objective: To investigate the association of acute-phase blood biomarker levels with SRC in collegiate athletes.
Broglio, Steven P., Brooks, M. Alison, Cameron, Kenneth L., Campbell, Darren E., CARE Consortium Investigators, DiFiori, Jon, Duma, Stephan, Foroud, Tatiana, Gill, Jessica, Giza, Christopher C., Goldman, Joshua, Guskiewicz, Kevin, Harezlak, Jaroslaw, Houston, Megan N., Huber, Daniel L., Jackson, Jonathan C., Katz, Barry P., McAllister, Thomas W., McCrea, Michael, McGinty, Gerald, Meier, Timothy B., Mihalik, Jason, Nelson, Lindsay D., Pasquina, Paul, Rowson, Steven, Saykin, Andrew J., Svoboda, Steven J.   +26 more
core   +1 more source

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Advanced Science, EarlyView.
Spinal cord injury activates the liver to send extracellular vesicles loaded with RPS3 protein to the lesion site. These vesicles are taken up by neural stem cells and astrocytes, triggering NF‐κB signaling, impairing the regeneration of neurons and myelin, and promotes harmful inflammation, ultimately hindering recovery.
Peiwen Song, Zuomeng Wu, Yixiang Dong, Yunxiong Fang, Shiyu Bian, Daokuan Wang, Huang Fang, Yunlei Liu, Wang Ying, Jun Qian, Tianyu Han, Cailiang Shen   +11 more
wiley   +1 more source

Early phrenic motor neuron loss and transient respiratory abnormalities following unilateral cervical spinal cord contusion [PDF]

, 2013
Contusion-type cervical spinal cord injury (SCI) is one of the most common forms of SCI observed in patients. In particular, injuries targeting the C3-C5 region affect the pool of phrenic motor neurons (PhMNs) that innervates the diaphragm, resulting in ...
Adriaens, Dominique, Authelet, Michèle, Brion, Jean-Pierre, Frank, David M, Hala, Tamara J, Lepore, Angelo C, Nicaise, Charles, Pochet, Roland, Wright, Megan C   +8 more
core   +2 more sources

Small Strokes, Big Impact: Excessive Mortality After Acute Ischemic Stroke in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Acute ischemic stroke (AIS) in those with Parkinson's disease (PD) is a growing healthcare burden but mortality studies are significantly lacking. Objective To map short‐ and long‐term survival, stratified by relevant comorbidities and stroke characteristics.
Lee E. Neilson, Chen Lin, Anusha Mishra, Gregory D. Scott   +3 more
wiley   +1 more source

Gender and race in neurotrauma: part 1-identifying inequalities in leadership, academics, and clinical trial management

Frontiers in Neurology
Gender and racial equality, or the lack thereof, is a constantly recurring theme in neurosurgery and under-reported in neurotrauma literature. This perspective piece addresses the underrepresentation and challenges faced by women and racial minorities in
Isabella F. Churchill, Téa Sue, Ann M. Parr, Eve C. Tsai, Eve C. Tsai   +4 more
doaj   +1 more source

Decorin blocks scarring and cystic cavitation in acute and induces scar dissolution in chronic spinal cord wounds

Neurobiology of Disease, 2014
In the injured central nervous system (CNS), transforming growth factor (TGF)-β1/2-induced scarring and wound cavitation impede axon regeneration implying that a combination of both scar suppression and axogenic treatments is required to achieve ...
Zubair Ahmed, Daljeet Bansal, Katie Tizzard, Sarina Surey, Maryam Esmaeili, Ana Maria Gonzalez, Martin Berry, Ann Logan   +7 more
doaj   +1 more source