Results 11 to 20 of about 183,502 (305)

Synergistic neurotrophic effects of piracetam and thiotriazoline

open access: yesНеврология, нейропсихиатрия, психосоматика, 2016
The paper considers the synergy between the nootropic drug piracetam and the metabolic agent thiotriazoline that maintains energy metabolism and survival of neurons and other types of cells. Piracetam, a nootropic drug, a chemical pyrrolidone derivative,
O. A. Gromova   +3 more
doaj   +3 more sources

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

open access: yesNeurobiology of Disease, 2014
Besides the presence of amyloid beta (Aβ) plaques and neurofibrillary tangles, neurogenesis and synaptic plasticity are markedly impaired in Alzheimer's disease (AD) possibly contributing to cognitive impairment.
Syed Faraz Kazim   +6 more
doaj   +3 more sources

Overexpression of TFEB Drives a Pleiotropic Neurotrophic Effect and Prevents Parkinson's Disease-Related Neurodegeneration. [PDF]

open access: yesMol Ther, 2018
Torra A   +8 more
europepmc   +2 more sources

Neurotrophic and Neuroprotective Effects of Hericium erinaceus

open access: yesInternational Journal of Molecular Sciences, 2023
Hericium erinaceus is a valuable mushroom known for its strong bioactive properties. It shows promising potential as an excellent neuroprotective agent, capable of stimulating nerve growth factor release, regulating inflammatory processes, reducing oxidative stress, and safeguarding nerve cells from apoptosis. The active compounds in the mushroom, such
Izabela Szućko-Kociuba   +3 more
openaire   +2 more sources

Neurotrophic and Neuroregenerative Effects of GH/IGF1 [PDF]

open access: yesInternational Journal of Molecular Sciences, 2017
Introduction. Human neurodegenerative diseases increase progressively with age and present a high social and economic burden. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are both growth factors exerting trophic effects on neuronal regeneration in the central nervous system (CNS) and peripheral nervous system (PNS).
Bianchi, VE, Locatelli, V, Rizzi, L
openaire   +2 more sources

Neurotrophic keratopathy: Clinical presentation and effects of cenegermin

open access: yesAmerican Journal of Ophthalmology Case Reports, 2022
To report on 4 patients (3 adults, 1 child) with neurotrophic keratopathy (NK) treated with cenegermin 20 μg/ml (Oxervate®), a recombinant human nerve growth factor (rhNGF), which was authorized by the European Medicines Agency for the treatment of neurotrophic keratopathy stage 2 and stage 3 of Mackie Classification in patients over 18 years of age ...
Julia Bing Bu   +3 more
openaire   +4 more sources

EFFECT OF GLYPROLINES ON THE LEVEL OF APOPTOTIC AND NEUROTROPHIC FACTORS UNDER CONDITIONS OF “SOCIAL” STRESS

open access: yesФармация и фармакология (Пятигорск), 2021
The aim of the article was to study the effect of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu, on the level of apoptotic factors (caspase-3, caspase-8, the tumor necrosis factor) and ...
A. L. Yasenyavskaya   +5 more
doaj   +1 more source

Synaptic Modulation by Neurotrophic Factors: Differential and Synergistic Effects of Brain-Derived Neurotrophic Factor and Ciliary Neurotrophic Factor [PDF]

open access: yesThe Journal of Neuroscience, 1996
Extracellular application of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) to developing neuromuscular junctions inXenopusnerve–muscle cultures resulted in an increase in the frequency of spontaneous synaptic currents (SSCs) and in the amplitude of nerve-evoked synaptic currents.
R, Stoop, M M, Poo
openaire   +2 more sources

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

open access: yes, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza   +3 more
core   +1 more source

2-Iodo-4′-Methoxychalcone Attenuates Methylglyoxal-Induced Neurotoxicity by Activation of GLP-1 Receptor and Enhancement of Neurotrophic Signal, Antioxidant Defense and Glyoxalase Pathway

open access: yesMolecules, 2019
Methylglyoxal (MG) acts as a reactive precursor of advanced glycation end products (AGEs). This compound is often connected with pathologies such as diabetes, neurodegenerative processes and diseases of aging.
Yu-Ting Tseng   +4 more
doaj   +1 more source

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