Neurourology and Urodynamics, EarlyView.ABSTRACT Introduction Overactive bladder (OAB) is defined as urinary urgency, usually accompanied by increased daytime frequency and/or nocturia, with urgency urinary incontinence (OAB‐wet) or without (OAB‐dry), in the absence of urinary tract infection or other detectable disease.
John E. Speich +9 more
wiley +1 more source
Hypothalamic-pituitary-adrenal axis activity and neurotrophic factors in drug-naive children and adolescents with attention-deficit/hyperactivity disorder. [PDF]
Front PsychiatryFerahkaya H +7 more
europepmc +1 more source
Mechanistic Insights of Zonisamide in Parkinson's Disease: A Systematic Review
Neurology and Clinical Neuroscience, EarlyView.ABSTRACT Zonisamide is an antiepileptic agent used as adjunctive therapy for Parkinson's Disease in Japan and studied more selectively elsewhere. Preclinical and early translational studies suggest that zonisamide may modulate several pathways relevant to Parkinson's Disease pathobiology, including dopaminergic neurotransmission, oxidative stress ...
Justin Kim +3 more
wiley +1 more source
Ischemic preconditioning modulates iron metabolism, acute inflammatory and neurotrophic responses to anaerobic exercise in untrained individuals: a randomized controlled trial. [PDF]
Sci RepBrzezińska P +10 more
europepmc +1 more source
Exercise, exerkines, and muscle–brain crosstalk in Parkinson's disease
Neuroprotection, EarlyView.Abstract Parkinson's disease (PD) is a progressive neurodegenerative disorder with motor and non‐motor symptoms, driven by dopaminergic loss and α‐synuclein accumulation. Beyond neurodegeneration, growing evidence highlights skeletal muscle health as a key determinant of prognosis, with sarcopenia and frailty contributing to greater disability, fall ...
Salomón Páez‐García +7 more
wiley +1 more source
Multiscale Mechanisms of Exercise-Induced Neuroplasticity: From Molecular Pathways to Network Dynamics and Behavioral Adaptation. [PDF]
Brain SciWang X +9 more
europepmc +1 more source
Neurotrophic Effects of Genipin on Neuro2a Cells
Neurotrophic Effects of Genipin on Neuro2a Cellsマウス神経芽細胞腫Neuro2a細胞中におけるゲニピンの神経分化誘導効果を検討した.ゲニピンは血清無添加・トランスフェリン/インスリン/プロゲステロン(TIP)添加培地で培養されたNeuro2a細胞中で,著しい神経突起伸長を濃度依存的に誘起した.この培地中では細胞増殖が抑制されたが,血清含有培地ではNeuro2a細胞の分裂が起きた.血清・TIP無添加培地は血清無添加・TIP添加培地に比べてトリパンブルーで染色される細胞数が明らかに増加していた.血清・TIP無添加培地にゲニピンを添加すると,細胞への障害は著しく減少した.神経分化誘導作用の陽性対照であるジブチリルcAMPも血清無添加・TIP添加培地中で神経突起伸長促進活性を誘起し,血清・TIP無添加培地中で培養細胞の生存率を促進した.以上より ...
openaire
Low-Intensity Pulsed Ultrasound in Peripheral and Central Nerve Repair: Mechanisms and Emerging Therapeutic Strategies. [PDF]
J Funct BiomaterMa C, Song S, Dai J, Shen H.
europepmc +1 more source
Phytochemical Analysis, EarlyView.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
wiley +1 more source
Pediatric Investigation, EarlyView.Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil +2 more
wiley +1 more source