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Seminars in Neuroscience, 1995
Abstract During development, nerve growth factor (NGF) is a target-derived survival factor for neurones of the peripheral nervous system. Very recently, NGF has been found to have novel physiological roles in adult animals. In particular, I will review here the evidence that NGF is a crucial molecule in the neurobiology of pain. In the last few years
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Abstract During development, nerve growth factor (NGF) is a target-derived survival factor for neurones of the peripheral nervous system. Very recently, NGF has been found to have novel physiological roles in adult animals. In particular, I will review here the evidence that NGF is a crucial molecule in the neurobiology of pain. In the last few years
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The Receptor for Ciliary Neurotrophic Factor
Science, 1991Although neurotrophic factors were originally isolated on the basis of their ability to support the survival of neurons, these molecules are now thought to influence many aspects of the development and maintenance of the nervous system. Identifying the receptors for these neurotrophic factors should aid in identifying the cells on which these factors ...
Samuel Davis +6 more
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Fast actions of neurotrophic factors
Current Opinion in Neurobiology, 1996A diversity of neurotrophic factors are required for the differentiation and survival of neurons and for maintaining their phenotype. By virtue of the rapid time scale of signal transduction in the cytosol, many of these factors also acutely regulate neuronal functions as diverse as synaptic transmission and nerve growth.
Mu-ming Poo, Benedikt Berninger
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1999
Preclinical and clinical data suggest that subcutaneous or intravenous administration of neurotrophic factors may be effective for the treatment of peripheral nervous system diseases. However, even though these proteins are natural products, they do present specific problems when used as therapeutic agents. They cannot be given by the oral route.
S. Pollack +4 more
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Preclinical and clinical data suggest that subcutaneous or intravenous administration of neurotrophic factors may be effective for the treatment of peripheral nervous system diseases. However, even though these proteins are natural products, they do present specific problems when used as therapeutic agents. They cannot be given by the oral route.
S. Pollack +4 more
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Neurotrophic factors and Alzheimer's disease
Neurobiology of Aging, 1989Defects in essential trophic interactions represent one possible explanation for the systems degenerations that occur in Alzheimer's as well as other neurodegenerative diseases. Since a multiplicity of neural pathways are affected in Alzheimer's disease, it is likely that more than one neurotrophic factor may be implicated. Through modern approaches in
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Role of neurotrophic factors in development
Trends in Genetics, 1988Abstract Neurotrophic factors are molecules which promote and regulate neuronal survival in the developing nervous system. They are distinguished from ubiquitous metabolites necessary for cellular maintenance and growth by their specificity: each neurotrophic factor promotes the survival of only certain kinds of neurons during a particular stage of ...
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Intracerebral Infusion of Neurotrophic Factors
2007Neurotrophic factors are among the most potent neuroprotective and neuroregenerative agents known. However, they cross the adult mammalian blood-brain barrier very poorly and can have serious peripheral side effects. These problems can be solved by using chronic infusions with small pumps to directly deliver known quantities of these proteins into ...
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Neurotrophic Factors and Neurodegeneration
1995Neurotrophic factors (NTFs) are molecules which act to promote the differentiation of neurons and to maintain their phenotype. The discovery by Hamburger and Levi- Montalcini in 1949 that the number of neurons in dorsal root ganglia was related to the size of the target field suggested that there exists a mechanism of neuronal support by which factors ...
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