Neurotrophic factors in the physiology of motor neurons and their role in the pathobiology and therapeutic approach to amyotrophic lateral sclerosis. [PDF]
Front Mol Neurosci, 2023 Stansberry WM, Pierchala BA.
europepmc +1 more source
Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular‐derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
Sara Gil‐Bernabé +5 more
wiley +1 more source
Building better brains: the pleiotropic function of neurotrophic factors in postnatal cerebellar development. [PDF]
Front Mol Neurosci, 2023 Boxy P, Nykjær A, Kisiswa L.
europepmc +1 more source
Annals of Neurology, EarlyView.Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang +10 more
wiley +1 more source
Application of Neurotrophic Factors as a Therapeutic Approach for Neurodegenerative Diseases. [PDF]
Exp NeurobiolKim SC, Lee SY, Jung UJ, Kim SR.
europepmc +1 more source
Decreased Serum Brain-Derived Neurotrophic Factor (BDNF) Levels in Patients with Alzheimer’s Disease (AD): A Systematic Review and Meta-Analysis [PDF]
, 2019 Ted Kheng Siang Ng +4 more
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Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice
Annals of Neurology, EarlyView.A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi +10 more
wiley +1 more source
Neurotrophic factors as double-edged swords in osteosarcoma: drivers of tumour growth and immune remodelling. [PDF]
Front ImmunolLei P, Li L.
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Exercise Improves Physical Capacity, Cognition, Quality of Life and Promotes Neurotrophic Factors in Patients with Multiple Sclerosis. [PDF]
Noro Psikiyatr Ars, 2023 Açık M +5 more
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