Results 281 to 290 of about 189,919 (333)

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Combined laser-activated SVF and PRP remodeled spinal sclerosis via activation of Olig-2, MBP, and neurotrophic factors and inhibition of BAX and GFAP. [PDF]

Sci Rep
Farid MF, Yasin NAE, Al-Mokaddem AK, Ibrahim MA, Abouelela YS, Rizk H.   +5 more
europepmc   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Epigenetic regulation in cognitive impairment: Focus on N6‐methyladenosine modification and its potential role in perioperative neurocognitive disorders

Ibrain, EarlyView.
N6‐methyladenosine (m6A), a key mammalian mRNA modification, affects cognition via gene regulation. This review explores its role in cognition and perioperative neurocognitive disorders (PNDs). Animal studies link m6A dysregulation to PND‐related mechanisms, but direct evidence is preliminary.
Ting Liu, Xiao‐Juan Yang, Lin Zhou, Mi Gan, Ting‐Ting He, Sen Hong, Yan‐Yan Feng, Gao Su, You‐Xiao Zhao, Ying Cao, Qing‐Fan Zeng   +10 more
wiley   +1 more source

Replication-defective herpes simplex virus vectors for neurotrophic factor gene transfer in vitro and in vivo

, 1999
Peggy Marconi, Michele Simonato, Silvia Zucchini, Gianni Bregola, Rafaela Argnani, D Krisky, Joseph C. Glorioso, Roberto Manservigi   +7 more
openalex   +1 more source

Magnesium Silicate Composite Patch With Neurovascular Regenerative Properties Promotes Diabetic Wound Healing in Mice

Interdisciplinary Materials, EarlyView.
The PCL‐PLLA‐MgSiO3 composite patch fabricated via electrospinning demonstrates superior therapeutic effects on diabetic wound healing compared to commercially available products, especially neurovascular network recovery. This will provide a promising bioactive patch for future clinical diabetic wound management.
Shunxiang Xu, Hongwei Shao, Zheyu Jin, Jiankun Xu, Fanyan Deng, Yuantao Zhang, Liangbin Zhou, Samuel Ka‐kin Ling, Congqin Ning, Wenxue Tong, Ling Qin   +10 more
wiley   +1 more source

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, EarlyView.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Resilience and Brain Changes in Long‐Term Ayahuasca Users: Insights From Psychometric and fMRI Pattern Recognition

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Ayahuasca is an Amazonian psychedelic brew that contains dimethyltryptamine (DMT) and beta carbolines. Prolonged use has shown changes in cognitive‐behavioral tasks, and in humans, there is evidence of changes in cortical thickness and an increase in neuroplasticity factors that could lead to modifications in functional neural ...
Lucas Rego Ramos, Orlando Fernandes Jr, Tiago Arruda Sanchez   +2 more
wiley   +1 more source

Harnessing psychedelics for treating posttraumatic stress disorder: Does the science support all the hype?

Journal of Traumatic Stress, EarlyView.
Abstract This paper is an edited transcript of a plenary panel held at the 2024 Annual Meeting of the International Society for Traumatic Stress Studies (ISTSS) in Boston, Massachusetts, United States. The panel comprised Drs. Mark Creamer (moderator), Richard Bryant (convenor), Amy Lehrner, Barbara O. Rothbaum, Joseph I. Ruzek, and Paula P.
Mark Creamer, Richard Bryant, Amy Lehrner, Barbara O. Rothbaum, Josef I. Ruzek, Paula P. Schnurr   +5 more
wiley   +1 more source