Results 291 to 300 of about 189,919 (333)

Sciatic Nerve Stimulation Mitigates Depression‐Like Behaviors and Memory Deficits in Stressed Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress causes depression and cognitive decline. With limitations in pharmacotherapy, sciatic nerve stimulation (SNS) offers a promising nondrug alternative. This study aimed to explore the therapeutic efficacy of SNS in mitigating stress‐induced depressive behaviors and memory deficits by focusing on astrocytic dysfunction and cellular ...
Chih‐Hao Tien, Pei‐Wen Chen, Ya‐Hsin Hsiao, Chia‐En Wong, Ming‐Tse Wu, Ying‐Fei Chen, Kuo‐Chang Huang, Po‐Hsuan Lee, Kun‐Chia Chang, Heng‐Juei Hsu, Jung‐Shun Lee   +10 more
wiley   +1 more source

Recent Advances in Injectable Hydrogel Biotherapeutics for Regenerative Dental Medicine

Macromolecular Bioscience, EarlyView.
This review analyses multifunctional injectable hydrogels, natural or synthetic, physically or chemically crosslinked, that deliver exosomes, stem cells, and other bioactive cues to inflamed or damaged oral tissues. We discuss their immunomodulatory, antimicrobial, angiogenic, and osteogenic capacities, highlighting advances that enable regenerative ...
Renan Dal‐Fabbro, Arwa Daghrery, Caroline Anselmi, Igor Paulino M. Soares, Alexandre Henrique dos Reis‐Prado, Pedro Henrique Chaves de Oliveira, Marco C. Bottino   +6 more
wiley   +1 more source

A Triple‐Layered Composite Scaffold of Silk Fibroin and Decellularized Amniotic Membrane for Bladder Tissue Engineering

Macromolecular Bioscience, EarlyView.
This study develops a triple‐layered scaffold for bladder regeneration using a SF/PEO film, decellularized human amniotic membrane, and a SF sponge seeded with ADSCs encapsulated in collagen hydrogel. The scaffold demonstrates excellent biocompatibility, mechanical properties resembling bladder tissue, and resistance to urinary stone formation, making ...
Melina Mamdoohi, Mehdi Shafieian, Zahra Hassannejad   +2 more
wiley   +1 more source

Mesenchymal Stem Cell‐Engrafted Bacterial Cellulose and Graphene Oxide Scaffolds Enhance Peripheral Nerve Repair in a Rat Model

Macromolecular Materials and Engineering, EarlyView.
This study investigates the use of graphene oxide‐decorated bacterial cellulose (BC/GO) scaffolds combined with mesenchymal stem cells (MSCs) to enhance axonal regeneration after sciatic nerve injury in rats. Graphene oxide is embedded monodispersely into the BC fibrillar matrix.
Ismail Simsek, Semra Unal, Efecan Cekic, Ecem Dogan, Ozlem Kirazli, Ferhat Harman   +5 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Intratumoral Nerve Phased Development: A Promising Therapeutic Target

Medicine Bulletin, EarlyView.
ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che, Hang Wang, Han Wang, Yi‐Zhou Jiang   +3 more
wiley   +1 more source

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Neurotrophic factors

Endeavour, 1985
In addition to nerve growth factor (NGF), many proteins present in soluble tissue extracts and in the extracellular matrix influence the survival and development of cultured neurons. The structure, synthesis, and mechanism of action of NGF as a neurotrophic factor are considered along with the experiments on the new putative trophic molecules.
H, Thoenen, D, Edgar
openaire   +4 more sources

Neurotrophic factors

Trends in Neurosciences, 1999
Publisher Summary This chapter discusses several classes of nervous system growth factors focusing on neurotrophic factors. In the peripheral nervous system (PNS), neurotrophic factors are survival factors for several classes of neurons. The availability of limited quantities of nerve growth factor (NGF) in a target-derived manner is essential for the
Gerta Vrbová, Antal Nógrádi, Linda Greensmith   +2 more
openaire   +5 more sources

Neurotrophic factors and their receptors

Annals of Neurology, 1994
Development of the nervous system depends on signals that instruct neurons when to divide, differentiate, survive, or die. There are now two known distinct classes of factors noted for their neurotrophic activities-the family of factors collectively known as the neurotrophins, and ciliary neurotrophic factor.
Ip, Nancy Yuk-Yu LIFS, Yancopoulos, George D.   +1 more
openaire   +6 more sources

Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors

Brain Research Reviews, 1999
Neurotrophins and other neurotrophic factors have been shown to support the survival and differentiation of many neuronal populations of the central and peripheral nervous system. Therefore, administering neurotrophic factors could represent an alternative strategy for the treatment of acute and chronic brain disorders.
Irina Semkova, Josef Krieglstein
openaire   +2 more sources