Genomics and Histopathology in Interstitial Cystitis/Bladder Pain Syndrome
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims In April of 2025, a Global Consensus meeting on IC/BPS was held in Winston‐Salem, NC. The goal of this meeting was to establish global consensus in diagnostic criteria, phenotyping, treatment outcome assessment, and possible etiopathology in interstitial cystitis/bladder pain syndrome (IC/BPS).
Hannah Ruetten +4 more
wiley +1 more source
Role of Acid‐Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota
Obesity, EarlyView.ABSTRACT Objective Acid‐sensing ion channels are proton‐activated ion channels predominantly found in the nervous system. They are well known to affect metabolic and neurological health, yet their role in obesity and gut physiology remains unclear. This study investigates how systemic deletion of Asic1a influences obesity, metabolic, and gut‐based ...
Jane Shearer +7 more
wiley +1 more source
Pediatric Discovery, EarlyView.The JNK pathway and oxidative stress are activated, and pro‐inflammatory cytokines are increased in neonatal maternal separation (NMS) rats. While docosahexaenoic acid treatment suppresses the activation of JNK pathway and oxidative stress, and reduces pro‐inflammatory cytokines release, thereby improving autism‐like behavior induced by NMS.
Boqing Xu +5 more
wiley +1 more source
Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu +3 more
wiley +1 more source
Expression of G2019S LRRK2 in Rat Primary Astrocytes Mediates Neurotoxicity and Alters the Dopamine Synthesis Pathway in N27 Cells via Astrocytic Proinflammatory Cytokines and Neurotrophic Factors. [PDF]
Curr Issues Mol BiolHo DH +5 more
europepmc +1 more source
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell +4 more
wiley +1 more source
Serum levels of interleukin-33 and mesencephalic astrocyte derived neurotrophic factors in patients with major depressive disorder: a cross-sectional comparative design. [PDF]
BMC PsychiatryNahar Z +6 more
europepmc +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Flavonoids are natural secondary metabolites of plants with a basic composition derived from polyphenols that can produce a plethora of different neurophysiological effects, some of which are relevant to anxiety disorders. As such, many flavonoids have been evaluated in behavioral screens in preclinical research on anxiolytics.
Jhennify Albuquerque Machado +7 more
wiley +1 more source