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The Clinical Journal of Pain, 2000
Neurotrophic factors have been shown to play significant roles in the transmission of physiologic and pathologic pain. Nerve growth factor appears to be particularly important. It is crucial for the development of sympathetic and small fiber sensory neurons that serve as nociceptors. It stimulates the expression and release of neuropeptides involved in
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Neurotrophic factors have been shown to play significant roles in the transmission of physiologic and pathologic pain. Nerve growth factor appears to be particularly important. It is crucial for the development of sympathetic and small fiber sensory neurons that serve as nociceptors. It stimulates the expression and release of neuropeptides involved in
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PHARMACOLOGY OF NEUROTROPHIC FACTORS
Annual Review of Pharmacology and Toxicology, 1997▪ Abstract The field of neurotrophic factor pharmacology emerged during the past decade with the discovery that these proteins can counteract neuronal atrophy and death in the adult nervous system. These concepts are being tested in clinical trials. Therapeutic use of neurotrophic proteins seems practical for diseases of the peripheral nervous system
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Neurotrophic factors and status epilepticus
Epilepsia, 2018SummaryBecause of their strong effects on cell survival and on synaptic function, neurotrophic factors (NTFs) have been hypothesized to be involved in some aspects of status epilepticus (SE) and in its possible consequences. This hypothesis has been explored mainly for 2NTFs, namely fibroblast growth factor 2 (FGF‐2) and brain‐derived neurotrophic ...
Michele Simonato, Michele Simonato
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The Pharmacology of Neurotrophic Factors [PDF]
, 1995 Since the early discoveries of Rita Levi-Montalcini and coworkers [1] the field of neurotrophic factors has expanded dramatically, and has become a pharmacological subject. We are facing a great number of neurotrophic factors (NTFs) with defined biological actions and conceptual therapeutic potential.
Hans Thoenen, A. Claudio Cuello
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PEDF: a multifaceted neurotrophic factor [PDF]
Nature Reviews Neuroscience, 2003 Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as glutamate excitotoxicity and oxidative damage. Since the crystal structure of PEDF was solved, its biological actions have begun to be mapped to specific structural ...
Colin J. Barnstable, Joyce Tombran-Tink
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Neurotrophic factors and their receptors
Current Opinion in Cell Biology, 1995Several new members of the nerve growth factor family of neurotrophins, which comprises nerve growth factor itself, brain-derived neurotrophic factor and neurotrophins-3, -4 (also known as neurotrophin-5) and -6, have been isolated in recent years.
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Sortilins in Neurotrophic Factor Signaling
2014The sortilin family of Vps10p-domain receptors includes sortilin, SorLA, and SorCS1-3. These type-I transmembrane receptors predominate in distinct neuronal tissues, but expression is also present in certain specialized non-neuronal cell populations including hepatocytes and cells of the immune system.
Glerup, S +2 more
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Neurotrophic factors in regeneration
Current Opinion in Neurobiology, 1991Nerve growth factor, fibroblast growth factor, and ciliary neurotrophic factor can protect selected populations of neurons from some of the degenerative changes that otherwise follow axonal injury or other insults. The function of diffusible neurotrophic factors in axonal regeneration is still unclear, however.
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Neurotrophic Factors in the Auditory Periphery
Annals of the New York Academy of Sciences, 1999ABSTRACT:Many of the neurotrophic factors promote the survival of developing peripheral sensory neurons, and they might be useful as therapeutic agents in the adult neuronal systems. During development, neurotrophin‐3 (NT‐3) and brain‐derived neurotrophic factor (BDNF) mRNAs are expressed in the auditory sensory epithelium, which composes the ...
Ulla Pirvola +3 more
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2008
The nervous system growth factors, or neurotrophic factors, comprise several families of proteins that influence neuronal survival, neuritic outgrowth, and cell function from embryonic development through old age. Given their extensive influences on neurons, neurotrophic factors represent candidate mechanisms for treating neurodegenerative and axonal ...
Eugene M. Johnson, Mark H. Tuszynski
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The nervous system growth factors, or neurotrophic factors, comprise several families of proteins that influence neuronal survival, neuritic outgrowth, and cell function from embryonic development through old age. Given their extensive influences on neurons, neurotrophic factors represent candidate mechanisms for treating neurodegenerative and axonal ...
Eugene M. Johnson, Mark H. Tuszynski
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