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Role of neurotrophic factors in depression
Current Opinion in Pharmacology, 2007Major depression is associated with reduced volumes in the hippocampus and prefrontal cortex, whereas antidepressant treatments promote several forms of neuronal plasticity, including neurogenesis, synaptogenesis and neuronal maturation, in the hippocampus. Several neurotrophic factors are associated with depression or antidepressant action.
Vootele Voikar +2 more
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Neurotrophic Factors: An Overview
2017The neurotrophins are a family of closely related proteins that were first identified as survival factors for sympathetic and sensory neurons and have since been shown to control a number of aspects of survival, development, and function of neurons in both the central and peripheral nervous systems.
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Neurotrophic Factors in Neuromuscular Disease
Physical Medicine and Rehabilitation Clinics of North America, 2005Neurotrophic factors (NTFs) are small dimeric proteins essential for development, function, maintenance, and plasticity of the vertebrate nervous system [1]. NTFs include glial-derived neurotrophic factor (GDNF), insulin-like growth factor 1 and 2 (IGF-1/2), ciliary neurotrophic factor (CNTF), vascular endothelial growth factor (VEGF) and the ...
Michael D. Weiss, B. Jane Distad
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Ciliary neurotrophic factor as an injury factor
Current Opinion in Neurobiology, 1993This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting.
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Seminars in Neuroscience, 1995
Abstract During development, nerve growth factor (NGF) is a target-derived survival factor for neurones of the peripheral nervous system. Very recently, NGF has been found to have novel physiological roles in adult animals. In particular, I will review here the evidence that NGF is a crucial molecule in the neurobiology of pain. In the last few years
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Abstract During development, nerve growth factor (NGF) is a target-derived survival factor for neurones of the peripheral nervous system. Very recently, NGF has been found to have novel physiological roles in adult animals. In particular, I will review here the evidence that NGF is a crucial molecule in the neurobiology of pain. In the last few years
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The Receptor for Ciliary Neurotrophic Factor
Science, 1991Although neurotrophic factors were originally isolated on the basis of their ability to support the survival of neurons, these molecules are now thought to influence many aspects of the development and maintenance of the nervous system. Identifying the receptors for these neurotrophic factors should aid in identifying the cells on which these factors ...
Samuel Davis +6 more
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Fast actions of neurotrophic factors
Current Opinion in Neurobiology, 1996A diversity of neurotrophic factors are required for the differentiation and survival of neurons and for maintaining their phenotype. By virtue of the rapid time scale of signal transduction in the cytosol, many of these factors also acutely regulate neuronal functions as diverse as synaptic transmission and nerve growth.
Mu-ming Poo, Benedikt Berninger
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1999
Preclinical and clinical data suggest that subcutaneous or intravenous administration of neurotrophic factors may be effective for the treatment of peripheral nervous system diseases. However, even though these proteins are natural products, they do present specific problems when used as therapeutic agents. They cannot be given by the oral route.
S. Pollack +4 more
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Preclinical and clinical data suggest that subcutaneous or intravenous administration of neurotrophic factors may be effective for the treatment of peripheral nervous system diseases. However, even though these proteins are natural products, they do present specific problems when used as therapeutic agents. They cannot be given by the oral route.
S. Pollack +4 more
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Other neurotrophic factors: Glial cell line‐derived neurotrophic factor (GDNF)
Microscopy Research and Technique, 1999Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is a more potent survival factor for dopaminergic neurons and the noradrenergic neurons of the locus coeruleus than other ...
Hannu Sariola, Mart Saarma
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Neurotrophic factors and Alzheimer's disease
Neurobiology of Aging, 1989Defects in essential trophic interactions represent one possible explanation for the systems degenerations that occur in Alzheimer's as well as other neurodegenerative diseases. Since a multiplicity of neural pathways are affected in Alzheimer's disease, it is likely that more than one neurotrophic factor may be implicated. Through modern approaches in
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