Results 311 to 320 of about 12,648,804 (372)

Ciliary Neurotrophic Factor Induces Down-regulation of Its Receptor and Desensitization of Signal Transduction Pathways

open access: hybrid, 1996
Peter S. DiStefano   +6 more
openalex   +1 more source

Conductive Materials and Electrical Stimulation for Auditory Restoration

open access: yesSensory Neuroscience, EarlyView.
Applications of electroconductive biomaterials and electrical stimulation in cochlear tissue engineering.(1) Enable auditory neural repair through conductive materials and electrical stimulation, enhancing neuron survival and synaptic plasticity.(2) Integrate optogenetic‐electrical systems and cochlear organoid platforms for frequency‐specific ...
Menghui Liao   +8 more
wiley   +1 more source

Regenerating the Senses: Stem Cell‐Derived Sensory Neurons and Functional Genomics in Neurological Disorders

open access: yesSensory Neuroscience, EarlyView.
ABSTRACT Sensory neuron disorders, such as peripheral neuropathies and trigeminal neuralgia, cause chronic pain and sensory dysfunction; however, regenerative treatments are limited. Human pluripotent stem cells (hPSCs) provide a powerful platform to model these diseases by generating functional sensory neuron subtypes, including nociceptors and ...
Pushpanathan Muthuirulan   +3 more
wiley   +1 more source

Biomaterial‐Based Emergency Intervention for Secondary Spinal Cord Injury

open access: yesSmall Science, EarlyView.
Emergency intervention using advanced biomaterials targets key pathological mechanisms to block secondary spinal cord injury (SCI) by inhibiting inflammation, reducing excitotoxicity, restoring the blood−spinal cord barrier, and limiting scar formation, which provides significant neural protection and promotes neural regeneration, offering promising ...
Jincheng Li   +5 more
wiley   +1 more source

Perineural Invasion in Pancreatic Ductal Adenocarcinoma: Recapitulating Its Importance and Defining Future Directions

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal malignancies, mainly due to its aggressive nature, early metastasis, diagnosis at late stages, and limited response to systemic anticancer therapy. Perineural invasion (PNI), defined as the infiltration of neoplastic cells along nerve fibers and within nerve sheaths, is ...
Martin Lovecek   +10 more
wiley   +1 more source

Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery   +43 more
wiley   +1 more source

Exercise in Pregnancy and Risk of Postpartum Depression: A Randomised Controlled Trial

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate whether regular aerobic exercise during pregnancy reduces the incidence of postpartum depression in women with low‐risk singleton pregnancies. Design Single‐centre randomised controlled trial. Setting Department of Obstetrics and Gynaecology, University of Naples Federico II, Italy.
Gabriele Saccone   +6 more
wiley   +1 more source

Brain DNA Methylation Atlas of AppNL‐G‐F Alzheimer's Disease Model Mice Across Age and Region Reveals Choline‐Induced Resilience

open access: yesAging Cell, EarlyView.
Brain DNA methylation drives abnormal gene expression in AppNL‐G‐F mice. Perinatal choline supplementation may promote resilience to synaptic dysfunction through modulation of DNA methylation. ABSTRACT Alzheimer's disease (AD) is the most common type of dementia.
Andre Krunic   +7 more
wiley   +1 more source

Variations in alcohol craving and negative mood during a clinical trial of ibudilast for alcohol use disorder

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
Neuroimmune compounds are being investigated as novel treatments for alcohol use disorder (AUD). This secondary analysis of a randomized clinical trial of ibudilast for AUD (N = 102) evaluated changes in self‐report symptom measures of craving, depression, and anxiety collected monthly over 12 weeks.
Lindsay R. Meredith   +3 more
wiley   +1 more source

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