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Role of neurotrophic factors in development
Trends in Genetics, 1988Abstract Neurotrophic factors are molecules which promote and regulate neuronal survival in the developing nervous system. They are distinguished from ubiquitous metabolites necessary for cellular maintenance and growth by their specificity: each neurotrophic factor promotes the survival of only certain kinds of neurons during a particular stage of ...
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The changing scene of neurotrophic factors
Trends in Neurosciences, 1991The purification of brain-derived neurotrophic factor (BDNF), the elucidation of its primary structure, and the subsequent identification of neurotrophin-3 (NT-3) ended the monopoly of NGF as the only well-characterized, target-derived neurotrophic molecule. NGF, BDNF and NT-3 are members of a gene family called neurotrophins.
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Neurotrophic Factors and Neurodegeneration
1995Neurotrophic factors (NTFs) are molecules which act to promote the differentiation of neurons and to maintain their phenotype. The discovery by Hamburger and Levi- Montalcini in 1949 that the number of neurons in dorsal root ganglia was related to the size of the target field suggested that there exists a mechanism of neuronal support by which factors ...
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