Results 191 to 200 of about 16,647,982 (293)

NRN1 as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Neuritin‐1 (NRN1) was identified as a synaptic protein associated with cognitive resilience to Alzheimer's disease (AD). METHODS Target risk score and cell type expression profiles were generated for NRN1 using methods developed by the Emory‐Sage‐SGC‐JAX Target Enablement to Accelerate Therapy Development for Alzheimer's Disease ...
Derian A. Pugh, Gregory A. Cary, Kelsey M. Greathouse, Lauren C. Nassour‐Caswell, Emma L. Hobby, Nicholas T. Seyfried, Jeremy H. Herskowitz   +6 more
wiley   +1 more source

Neurotrophin-3 Promotes the Neuronal Differentiation of BMSCs and Improves Cognitive Function in a Rat Model of Alzheimer's Disease. [PDF]

Front Cell Neurosci, 2021
Yan Z, Shi X, Wang H, Si C, Liu Q, Du Y.
europepmc   +1 more source

Targeted blood proteome profiling using NULISAseq identifies a high‐performance biomarker panel for Aβ pathology quantification and staging

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION While current blood‐based biomarkers for Alzheimer's disease (AD) are effective for determining amyloid beta (Aβ) pathology positivity/negativity, they are insufficient for quantifying Aβ plaque deposition. METHODS We profiled 325 plasma proteins in a Hong Kong Chinese cohort using the Nucleic Acid Linked Immuno‑Sandwich Assay ...
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K. W. Cheng, Elaine Y. L. Cheng, Bonnie W. Y. Wong, Ronnie M. N. Lo, Siu Ki Leung, Fanny C. Ip, Jacqueline K. Y. Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K. Y. Fu, Nancy Y. Ip   +22 more
wiley   +1 more source

Is There any Possible Role of Neurotrophin 3 in the Pathogenesis of Antrochoanal Polyp? [PDF]

Medeni Med J, 2020
Ozcan C, Ismi O, Kara T, Polat G, Erdogan O, Balci Fidanci S, Vayisoglu Y, Gorur K.   +7 more
europepmc   +1 more source

Neurotrophin-3 contributes to benefits of human embryonic stem cell-derived cardiovascular progenitor cells against reperfused myocardial infarction. [PDF]

Stem Cells Transl Med, 2021
Bi W, Wang J, Jiang Y, Li Q, Wang S, Liu M, Liu Q, Li F, Paul C, Wang Y, Yang HT.   +10 more
europepmc   +1 more source

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, Volume 99, Issue 2, Page 393-407, February 2026.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

Cell, 1991
R. Klein, V. Nanduri, Shuqian Jing, F. Lamballe, P. Tapley, S. Bryant, C. Cordon-Cardo, K. Jones, L. Reichardt, M. Barbacid   +9 more
semanticscholar   +1 more source

Recombinant Human Neuregulin1‐β1 Significantly Reduces Schwannoma Growth in Mice

Annals of Neurology, Volume 99, Issue 2, Page 369-381, February 2026.
[Color figure can be viewed at www.annalsofneurology.org] rhNRGβ1‐Replacement‐Therapy: Under physiological conditions, NRGβ1 is expressed on axons (in orange), where it activates ERBB2 receptors, facilitating successful nerve regeneration following injury.
Julia P. Bischoff, Alexander Schulz, Christian Hagel, Robert Büttner, Michael Reuter, Waylan K. Bessler, D. Wade Clapp, Helen Morrison   +7 more
wiley   +1 more source

Neurotrophin-3 stimulates stem Leydig cell proliferation during regeneration in rats. [PDF]

J Cell Mol Med, 2020
Yu Y, Li Z, Ma F, Chen Q, Lin L, Xu Q, Li Y, Xin X, Pan P, Huang T, Wang Y, Fei Q, Ge RS.   +12 more
europepmc   +1 more source

The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia. [PDF]

Int J Mol Sci, 2021
Rodrigues-Amorim D, Iglesias-Martínez-Almeida M, Rivera-Baltanás T, Fernández-Palleiro P, Freiría-Martínez L, Rodríguez-Jamardo C, Comís-Tuche M, Vallejo-Curto MDC, Álvarez-Ariza M, López-García M, de Las Heras E, García-Caballero A, Olivares JM, Spuch C.   +13 more
europepmc   +1 more source