Results 251 to 260 of about 16,647,982 (293)

Schizophrenia and neurotrophin‐3 alleles

Acta Psychiatrica Scandinavica, 1997
Studies of brain anatomy and premorbid functioning indicate that schizophrenia may be of neurodevelopmental origin. In the neurotrophic factor neurotrophin‐3 (NT‐3) gene, the A3/147‐bp allele in a dinucleotide repeat polymorphism located in the promoter region was found to be associated with schizophrenia in a Japanese study. Another NT‐3 polymorphism (
E, Jŏnsson, S, Brené, X R, Zhang, V L, Nimgaonkar, A, Tylec, M, Schalling, G, Sedvall   +6 more
openaire   +2 more sources

Monoclonal Antibodies against Human Neurotrophin-3

Biochemical and Biophysical Research Communications, 1993
Hybridomas producing monoclonal antibodies (MoAbs) against human neurotrophin-3 (hNT-3) were established using recombinant hNT-3 produced in CHO cells and E. coli as immunogens. Of the five MoAbs obtained, MoAb 3w3 showed the highest antibody titer and also best neutralized NT-3 activity as measured by the survival of chick embryonic day-8 dorsal root ...
A, Shintani, T, Watanabe, K, Kuroshima, Y, Ichimori, T, Kurokawa, K, Igarashi, R, Sasada   +6 more
openaire   +2 more sources

Neurotrophin-3: a neurotrophic factor related to NGF and BDNF.

Science, 1990
The development and maintenance of the nervous system depends on proteins known as neurotrophic factors. Although the prototypical neurotrophic factor, nerve growth factor (NGF), has been intensively studied for decades, the discovery and ...
P. Maisonpierre, L. Belluscio, S. Squinto, N. Ip, M. Furth, R. Lindsay, G. Yancopoulos   +6 more
semanticscholar   +1 more source

NEUROTROPHIN‐3 EXPRESSION IN HUMAN PANCREATIC CANCERS

The Journal of Pathology, 1997
Some neurotrophic factors stimulate process outgrowth in peripheral and/or central nerve fibres. There is no published report that has focused on the expression of neurotrophic factors in human pancreatic cancer except basic fibroblast growth factor.
T, Ohta, M, Numata, Y, Tsukioka, F, Futagami, M, Kayahara, H, Kitagawa, T, Nagakawa, M, Yamamoto, T, Wakayama, Y, Kitamura, T, Terada, Y, Nakanuma   +11 more
openaire   +2 more sources

Nerve growth factor antibodies recognize neurotrophin-3

Neurochemical Research, 1993
The immunological properties of the neurotrophins NGF, BDNF, and NT-3 were compared using polyclonal and monoclonal antibodies against the beta subunit of mouse NGF. Affinity-purified anti-NGF IgG consistently recognized NGF and NT-3 on Western blots, and inhibited the trophic activity of NGF and NT-3 but not BDNF.
A, Negro, V, Corsa, S D, Skaper, L, Callegaro   +3 more
openaire   +4 more sources

Neurotrophin‐3 gene polymorphism associated with schizophrenia

Acta Psychiatrica Scandinavica, 1994
The recent possible neurodevelopmental etiology of schizophrenia makes the neurotrophin‐3 (NT‐3) gene an interesting candidate locus. We studied the allelic distributions of dinucleotide repeat polymorphism at the NT‐3 gene locus in 70 patients with schizophrenia and in 70 controls. A highly significant difference between the two groups was observed at
S, Nanko, M, Hattori, S, Kuwata, T, Sasaki, R, Fukuda, X Y, Dai, K, Yamaguchi, Y, Shibata, H, Kazamatsuri   +8 more
openaire   +2 more sources

Neurotrophin-3 selectively increases cultured Purkinje cell survival

NeuroReport, 1994
Nerve growth factor (NGF) has been shown to promote the survival of cultured cerebellar Purkinje cells, when tested in conjunction with metabotropic receptor activation. In the present study, we examined the effects of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF).
H T, Mount, C F, Dreyfus, I B, Black
openaire   +2 more sources

Neurotrophin-3 deficient Schwann cells impair nerve regeneration

Experimental Neurology, 2008
Neurotrophin 3 (NT-3) is an important autocrine factor supporting Schwann cell (SC) survival and differentiation in the absence of axons. Prior studies have failed to define the explicit role of SC versus axon in NT-3 deficiency in relation to nerve regeneration and associated remyelination. In the paradigm we studied, using NT-3 heterozygous (NT3(+/-))
Zarife, Sahenk, Janet, Oblinger, Chris, Edwards   +2 more
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Sensory ganglia require neurotrophin-3 early in development

Development, 1994
ABSTRACT The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a mono-clonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neu-rotrophin-3 was initiated during completion of gangliogen-esis.
Gaese, F., Kolbeck, R., Barde, Y. A.
openaire   +3 more sources

Neurotrophin–3 is required for proper cerebellar development

Nature Neuroscience, 1999
Neurotrophin–3 (NT–3) is a member of the neurotrophin family, which includes nerve growth factor (NGF), brain–derived neurotrophic factor (BDNF) and neurotrophin–4/5 (NT–4/5). These factors are crucial for development of the peripheral nervous system1, but not the central nervous system (CNS), except that NT–3 and BDNF have been implicated in the ...
B, Bates, M, Rios, A, Trumpp, C, Chen, G, Fan, J M, Bishop, R, Jaenisch   +6 more
openaire   +2 more sources