Results 261 to 270 of about 16,647,982 (293)

Neurotrophin‐3 signaling in mammalian Merkel cell development

Developmental Dynamics, 2003
AbstractMerkel cells are sensory cells of neural crest origin. Because little is known about the mechanisms that direct their differentiation, we have investigated the potential role of a candidate regulatory factor, neurotrophin‐3 (NT‐3). At embryonic day 16.5 (E 16.5), neither NT‐3 nor its primary receptors, TrkC and p75NTR are expressed by Merkel ...
Viktor, Szeder, Milos, Grim, Jan, Kucera, Maya, Sieber-Blum   +3 more
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Apoptosis of Merkel cells in neurotrophin-3 null mice

Anatomy and Embryology, 2005
Postnatal mice lacking neurotrophin-3 (NT3) are deficient in Merkel cells of touch domes and whisker follicles. We examined the mechanism of Merkel cell loss by immunocytochemistry and electron microscopy. Merkel cell of whisker follicles of NT3 null newborns exhibited decreased immunoreactivity for cytokeratin 8 and contained apoptotic bodies that ...
Zdenek, Halata, Jan, Kucera, Tomas, Kucera, Milos, Grim   +3 more
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Dependence of developing group Ia afferents on neurotrophin‐3

Journal of Comparative Neurology, 1995
AbstractAt birth, group Ia proprioceptive afferents and muscle spindles, whose formation is Ia afferent‐dependent, are absent in mice carrying a deletion in the gene for neurotrophin‐3 (NT‐3 –/–). Whether Ia afferents contact myotubes, resulting in the formation of spindles which subsequently degenerate, or whether Ia afferents and spindles never form ...
J, Kucera, G, Fan, R, Jaenisch, S, Linnarsson, P, Ernfors   +4 more
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Decreased serum neurotrophin 3 in chronically medicated schizophrenic males

Neuroscience Letters, 2008
There is evidence that major psychiatric disorders such as schizophrenia (SZ) are associated with deregulation of synaptic plasticity with downstream alterations of neurotrophins. NT3 is an important neurotrophin in the central nervous system, and performs key biological functions, such as promoting the survival, differentiation, and plasticity of ...
Vargas, Haroldo Evangelista, Gama, Clarissa Severino, Andreazza, Ana Cristina, Medeiros, Dalton, Stertz, Laura, Fries, Gabriel, Palha, Joana Almeida, Cereser, Keila Maria, Berk, Michael, Kapczinski, Flavio, Belmonte-de-Abreu, Paulo Silva   +10 more
openaire   +3 more sources

Investigation of neuromuscular abnormalities in neurotrophin‐3‐deficient mice

European Journal of Neuroscience, 2009
AbstractNeurotrophin‐3 (NT‐3) is a trophic factor that is essential for the normal development and maintenance of proprioceptive sensory neurons and is widely implicated as an important modulator of synaptic function and development. We have previously found that animals lacking NT‐3 have a number of structural abnormalities in peripheral nerves and ...
Philip W, Sheard, Guy S, Bewick, Adele G, Woolley, Jacqueline, Shaw, Lorryn, Fisher, Sitt Wai, Fong, Marilyn J, Duxson   +6 more
openaire   +2 more sources

A crucial role for neurotrophin-3 in oligodendrocyte development

Nature, 1994
The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 promote the survival of subpopulations of vertebrate neurons in vitro, but so far only nerve growth factor has been demonstrated to be essential for normal neuronal development; no neurotrophin has previously been shown to function in normal ...
Barres, B. A., Raff, M. C., Gaese, F., Bartke, I., Dechant, G., Barde, Y. A.   +5 more
openaire   +2 more sources

Neurotrophin‐3 reverses experimental cisplatin‐induced peripheral sensory neuropathy

Annals of Neurology, 1995
AbstractCisplatin, a widely used chemotherapeutic agent, induces a sensory neuropathy with selective loss of vibration sense and proprioception. Here we demonstrate that neurotrophin‐3 (NT‐3), a member of the nerve growth factor family of neurotrophic factors, restored to normal levels the reduced H‐reflex‐related sensory nerve conduction velocity ...
W Q, Gao, N, Dybdal, N, Shinsky, A, Murnane, C, Schmelzer, M, Siegel, G, Keller, F, Hefti, H S, Phillips, J W, Winslow   +9 more
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Neurotrophin-3 gene polymorphisms and schizophrenia

Psychiatric Genetics, 1996
It has been suggested on the basis of neuropathological and epidemiological evidence that schizophrenia is, at least in part, a neurodevelopmental illness. Some patients show abnormalities in cell position in the medial temporal lobes of their brains. Neurotrophin-3 is one of many proteins essential for the proper growth and development of the nervous ...
Gill, M, Hawi, Z, O'Neill, F A, Walsh, D, Straub, R E, Kendler, K S   +5 more
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Neurotrophin 3 is increased in the spontaneously hypertensive rat

Journal of Hypertension, 2001
To determine whether the noradrenergic sympathetic hyperinnervation in the spontaneously hypertensive rat (SHR), a genetic model of essential hypertension, is associated with changes in neurotrophin 3 (NT3) concentrations.NT3 levels were measured using a sensitive enzyme-linked immunosorbent assay (ELISA) in the superior cervical ganglia (SCG), heart ...
S H, Zhang, R A, Rush
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In vivo effects of neurotrophin-3 during sensory neurogenesis

Development, 1996
ABSTRACT The neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 are structurally related proteins regulating the number of neurons in peripheral ganglia of the nervous system. Increased levels of nerve growth factor or of brain-derived neurotrophic factor selectively prevent normally occurring ...
Ockel, M., Lewin, G. R., Barde, Y. A.
openaire   +3 more sources