Results 141 to 150 of about 66,390 (268)
Annals of Clinical and Translational Neurology, Volume 13, Issue 5, Page 984-993, May 2026.ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung +7 more
wiley +1 more source
Advanced Biology, Volume 10, Issue 5, May 2026.This Perspective describes how the chaperone‐like domain BRICHOS from the Bri2 protein is found to be transported across brain vascular endothelial cells and into neurons in the central nervous system. The possibility that Bri2 BRICHOS can be used as a transport shuttle for biological drugs into the CNS is discussed.
Cloé Moëlo +2 more
wiley +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen +14 more
wiley +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li +8 more
wiley +1 more source
Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision [PDF]
, 2018 Adak, Sangeeta +11 more
core +2 more sources
Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease
Advanced Science, Volume 13, Issue 27, 13 May 2026.This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang +15 more
wiley +1 more source
Regressive Neuroblastoma: Widely Accepted, Underreported Histology
Clinical Case Reports, Volume 14, Issue 5, May 2026.Whole‐mount section of the regressed neuroblastoma within the adrenal gland, showing a loose, collagenous, and edematous stroma. ABSTRACT Neuroblastoma accounts for approximately 8% of all pediatric cancers and up to 15% of pediatric cancer‐related deaths in malignant cases; neuroblastoma is the most common malignancy in infancy.
Tom Membrez +5 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.• Excitatory neurons and astrocytes show marked alterations in the single‐cell spatial transcriptomic atlas of epileptogenic cortex from patients with focal cortical dysplasia type I (FCDI). • The CBLN2high excitatory neuron subtype may be associated with neuronal hyperexcitability and cortical development in FCDI.
Yaqian Zhang +9 more
wiley +1 more source
Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation
Glia, Volume 74, Issue 5, May 2026.– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond +4 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie +7 more
wiley +1 more source