Results 1 to 10 of about 7,348 (116)
p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease [PDF]
Alzheimer’s Research & TherapyBackground Alzheimer’s Disease (AD) is a neurodegenerative disorder primarily characterized by memory loss and cognitive decline. The AD-driven impairment of adult hippocampal neurogenesis - the process of generating new neurons in the dentate gyrus - is
Maria Anna Papadopoulou +6 more
doaj +2 more sources
Taming the “death receptor”: translating the first-in-class p75NTR modulator LM11A-31 from basic biology, across broad preclinical models, to clinical proof-of-concept [PDF]
Journal of Translational MedicineBackground The p75 neurotrophin receptor (p75NTR) is a critical regulator of diverse biological processes. Depending on the cellular context, p75NTR can promote trophic or degenerative signaling, which can influence a broad spectrum of pathological ...
Vanessa F. Langness +4 more
doaj +2 more sources
Palmitoylation of death receptor p75NTR contributes to Alzheimer’s disease progression by regulating APP trafficking and degradation [PDF]
Alzheimer’s Research & TherapyAlthough protein palmitoylation has been associated with Alzheimer’s Disease (AD), it remains unclear whether or how palmitoylation of specific proteins contributes to any of the pathological features of AD.
Yanchen Ma, Meng Xie, Carlos F. Ibáñez
doaj +2 more sources
Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons [PDF]
Stem Cell Research & TherapyBackground Hyperglycemia, a hallmark of diabetes mellitus, is a metabolic condition that highly affects the nervous system. While evidence from epidemiological and animal studies links diabetes to dopaminergic dysfunction and an increased risk of ...
Konstantina Chanoumidou +11 more
doaj +2 more sources
Frontiers in Aging Neuroscience, 2022 The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ...
Samuel Fleury +17 more
doaj +1 more source
p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK
Frontiers in Cell and Developmental Biology, 2023 The circadian clock plays a critical role in dentomaxillofacial development. Tooth biomineralization is characterized by the circadian clock; however, the mechanisms underlying the coordination of circadian rhythms with tooth development and ...
Bo Xie +10 more
doaj +1 more source
Phenotype changes of oral epithelial stem cells after in vitro culture [PDF]
Brazilian Oral Research, 2020 The aim of our study was to isolate populations of keratinocyte stem cells based on the expression of cell surface markers and to investigate whether the culture could affect their phenotype.
Felipe Perozzo DALTOE +4 more
doaj +1 more source
Open Medicine, 2023 Can the spinal cord stimulation (SCS) regulate the autonomic nerves through the endothelin-1 (ET-1) and nerve growth factor (NGF)/p75NTR pathways and thus inhibit the occurrence of atrial fibrillation (AF)?
Peng Yiyan +5 more
doaj +1 more source
A review of studies on the roles of p75NTR in the tooth development and tissue regeneration [PDF]
Yixue xinzhi zazhi, 2020 p75NTR, a low affinity neurotrophic factor receptor, is considered as a typical neural crest marker. It has been reported that p75NTR not only played an important role in the proliferation, migration, differentiation, survival and apoptosis of neural ...
Shi-Ting LI, Xia YU, Xiu-Jie WEN
doaj +1 more source
Regenerative Therapy, 2021 Introduction: The p75 neurotrophin receptor (p75NTR) is known as an efficient marker for the prospective isolation of mesenchymal stem cells (MSCs) and neural crest-derived stem cells (NCSCs). To date, there is quite limited information concerning p75NTR-
Rina Fujii-Tezuka +7 more
doaj +1 more source