p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease [PDF]
Alzheimer’s Research & TherapyBackground Alzheimer’s Disease (AD) is a neurodegenerative disorder primarily characterized by memory loss and cognitive decline. The AD-driven impairment of adult hippocampal neurogenesis - the process of generating new neurons in the dentate gyrus - is
Maria Anna Papadopoulou +6 more
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Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons [PDF]
Stem Cell Research & TherapyBackground Hyperglycemia, a hallmark of diabetes mellitus, is a metabolic condition that highly affects the nervous system. While evidence from epidemiological and animal studies links diabetes to dopaminergic dysfunction and an increased risk of ...
Konstantina Chanoumidou +11 more
doaj +2 more sources
p75NTR regulates postnatal skeletal development via NGF-responsive JNK signaling [PDF]
Bone Reportsp75NTR has emerged as a key regulator of skeletal development and bone homeostasis. To define its role, we characterized skeletal phenotypes in global and mesenchyme-specific p75NTR knockout mouse models.
Chiho Kadota-Watanabe +11 more
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Peripheral Nerve Regeneration Is Independent From Schwann Cell p75NTR Expression
Frontiers in Cellular Neuroscience, 2019 Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal regeneration and re-myelination to occur following injury to peripheral nerves. The neurotrophin receptor p75NTR has been identified as a positive modulator for Schwann
Nadia P Gonçalves +2 more
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Single-cell analysis of ecto-mesenchymal cells derived from the neural crest reveals the regulatory role of P75NTR in odontogenic and osteogenic differentiation [PDF]
BMC Oral HealthBackground The aim to this study was to explore the effect of p75NTR on the mineralization and development of maxillofacial processes. Moreover, we tried to elaborate the potential mechanism of p75NTR’s effect on the odontogenic or osteogenic ...
Feng Li +5 more
doaj +2 more sources
P75NTR activation limits CD21lo B cell subsets expansion in response to autoimmune-inducing challenges [PDF]
iScienceSummary: Studies, including our own, suggest that p75NTR plays a pivotal role in immune regulation. Here, we aimed to uncover the role of p75NTR signaling in regulating CD21lo B cell subsets, which are known to facilitate autoimmune activity, and to ...
Cong Luo +5 more
doaj +2 more sources
Frontiers in Aging Neuroscience, 2022 The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ...
Samuel Fleury +17 more
doaj +1 more source
p75NTR promotes tooth rhythmic mineralization via upregulation of BMAL1/CLOCK
Frontiers in Cell and Developmental Biology, 2023 The circadian clock plays a critical role in dentomaxillofacial development. Tooth biomineralization is characterized by the circadian clock; however, the mechanisms underlying the coordination of circadian rhythms with tooth development and ...
Bo Xie +10 more
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Phenotype changes of oral epithelial stem cells after in vitro culture [PDF]
Brazilian Oral Research, 2020 The aim of our study was to isolate populations of keratinocyte stem cells based on the expression of cell surface markers and to investigate whether the culture could affect their phenotype.
Felipe Perozzo DALTOE +4 more
doaj +1 more source
Open Medicine, 2023 Can the spinal cord stimulation (SCS) regulate the autonomic nerves through the endothelin-1 (ET-1) and nerve growth factor (NGF)/p75NTR pathways and thus inhibit the occurrence of atrial fibrillation (AF)?
Peng Yiyan +5 more
doaj +1 more source