Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor
Cell Reports, 2012 Structural determinants underlying signaling specificity in the tumor necrosis factor receptor superfamily (TNFRSF) are poorly characterized, and it is unclear whether different signaling outputs can be genetically dissociated.
Ioannis Charalampopoulos +5 more
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Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood
Regenerative Therapy, 2020 Introduction: Neural crest (NC)-like stem/progenitor cells provide an attractive cell source for regenerative medicine because of their multipotent property and ease of isolation from adult tissue.
Zena Al-Bakri +7 more
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Journal of Neuroinflammation, 2021 Background Streptococcus pneumoniae meningitis is a destructive central nervous system (CNS) infection with acute and long-term neurological disorders. Previous studies suggest that p75NTR signaling influences cell survival, apoptosis, and proliferation ...
Dandan Zhang +8 more
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p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes. [PDF]
, 2011 p75 neurotrophin receptor (p75NTR) belongs to the TNF-receptor superfamily and signals apoptosis in many cell settings. In human epidermis, p75NTR is mostly confined to the transit-amplifying (TA) sub-population of basal keratinocytes.
DALLAGLIO, Katiuscia +9 more
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p75 Neurotrophin Receptor Suppresses the Proliferation of Human Gastric Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2007 Identifying an effective therapeutic target is pivotal in the treatment of gastric cancer. In this study, we investigated the expression of p75 neurotrophin receptor (p75NTR) in gastric cancer and the impact of its alteration on tumor growth.
Haifeng Jin +10 more
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NADE, a p75NTR-associated Cell Death Executor, Is Involved in Signal Transduction Mediated by the Common Neurotrophin Receptor p75NTR [PDF]
Journal of Biological Chemistry, 2000 The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell death of neural cells by NGF and other neurotrophins. To elucidate p75NTR-mediated signal transduction, we screened p75NTR-associated proteins by a yeast two-hybrid system.
J, Mukai +10 more
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Acta Neuropathologica Communications, 2019 The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression of the p75NTR pan-neurotrophin
Viviana Pérez +13 more
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Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer [PDF]
, 2016 The high affinity nerve growth factor (NGF) NGF receptor, p75NTR, is a member of the tumor necrosis factor (TNF) receptor superfamily that shares a conserved intracellular death domain capable of inducing apoptosis and suppressing growth in prostate ...
Biordi, Leda +9 more
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p75NTR as a Molecular Memory Switch [PDF]
, 2019 In recent years, many molecular and environmental factors have been studied to understand how synaptic plasticity is modulated. Sleep, as an evolutionary conserved biological function, has shown to be a critical player for the consolidation and filtering of synaptic circuitry underlying memory traces.
Ning, Shen, Jorfi, Mehdi
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FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis [PDF]
, 2007 After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously,
Barnett, S.C. +7 more
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