Results 31 to 40 of about 9,698 (210)
NADE, a p75NTR-associated Cell Death Executor, Is Involved in Signal Transduction Mediated by the Common Neurotrophin Receptor p75NTR [PDF]
Journal of Biological Chemistry, 2000 The low affinity neurotrophin receptor p75NTR can mediate cell survival as well as cell death of neural cells by NGF and other neurotrophins. To elucidate p75NTR-mediated signal transduction, we screened p75NTR-associated proteins by a yeast two-hybrid system.
J, Mukai +10 more
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Acta Neuropathologica Communications, 2019 The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or neurodegeneration, motor neurons and Schwann cells increase the expression of the p75NTR pan-neurotrophin
Viviana Pérez +13 more
doaj +1 more source
BMC Neuroscience, 2011 Background The presence of neurotrophins and their receptors Trk family has been reported in the choroid plexus. High levels of Nerve Growth Factor (NGF), Neurotrophin-4 (NT-4) and TrkB receptor were detected, while nothing was know about p75 ...
Spuch Carlos, Carro Eva
doaj +1 more source
p75NTR as a Therapeutic Target for Neuropsychiatric Diseases
Current Molecular Pharmacology, 2009 The p75 neurotrophin receptor (p75NTR) was originally identified as a low-affinity receptor for neurotrophins. Recent studies have revealed that p75NTR can promote cell death or survival and modulate neurite outgrowth depending on the operative ligands and co-receptors.
Takashi, Fujii, Hiroshi, Kunugi
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, 2022 Control of lipid metabolism by NGF/p75NTR signaling in neuron-glia network: novel targets for neurodegenerative diseases A prominent factor in cognitive abnormalities associated with various neurodegenerative diseases, including Alzheimer's Disease (AD ...
Viviana Triaca +6 more
core
PLoS ONE, 2012 BackgroundAlthough p75 neurotrophin receptor (p75NTR) is the first neurotrophin receptor isolated, its diverse physiological functions and signaling have remained elusive for many years. Loss-of-function phenotypic analyses for p75NTR were mainly focused
Congcong Zhang +8 more
doaj +1 more source
, 2013 NSC19 cells were transiently transfected with the p75NTR-specific ER retained intrabodies or the control αphOx-KDEL. Four days after transfection, the p75NTR surface expressions were determined with mouse anti-p75NTR mAb (MLR2, 1∶200) followed by goat ...
Andrea L. J. Marschall (334275) +8 more
core +1 more source
p75 Neurotrophin Receptor Regulates Energy Balance in Obesity
Cell Reports, 2016 Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD).
Bernat Baeza-Raja +16 more
doaj +1 more source
p75NTR as a Molecular Memory Switch [PDF]
, 2019 In recent years, many molecular and environmental factors have been studied to understand how synaptic plasticity is modulated. Sleep, as an evolutionary conserved biological function, has shown to be a critical player for the consolidation and filtering of synaptic circuitry underlying memory traces.
Shen Ning, Mehdi Jorfi
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p75NTR is involved in inflammatory responses in psoriasis
Psoriasis (Pso) is a chronic inflammatory disease of the skin. Toll-like receptors (TLRs) are involved in Pso pathogenesis and their intracellular pathways are activated after the binding with a variety of danger signals such as the alarmins, molecules released from damaged or diseased tissue that stimulate immunomodulatory responses. We recently found
A Magenta +9 more
openaire +2 more sources