Results 41 to 50 of about 9,698 (210)

NGF and P75NTR gene expression is associated with the hepatic fibrosis stage due to viral and non-viral causes. [PDF]

PLoS ONE, 2015
This study evaluated the relative mRNA expression levels of nerve growth factor (NGF) and the p75 neurothrophin receptor (p75NTR) in different histological stages of human liver disease.
Ednelza da Silva Graça Amoras, Samara Tatielle Monteiro Gomes, Felipe Bonfim Freitas, Bárbara Brasil Santana, Geraldo Ishak, Marialva Tereza Ferreira de Araújo, Sâmia Demachki, Simone Regina Souza da Silva Conde, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, Antonio Carlos Rosário Vallinoto   +10 more
doaj   +1 more source

p75 neurotrophin receptor regulates craniofacial growth and morphology in postnatal development

Frontiers in Cell and Developmental Biology
Craniofacial abnormalities are among the most prevalent congenital defects, significantly affecting appearance, function, and quality of life. While the role of genetic mutations in craniofacial malformations is recognized, the underlying molecular ...
Byron Zhao, Jinsook Suh, Yan Zhang, Eric Yin, Chiho Kadota-Watanabe, Chiho Kadota-Watanabe, In Won Chang, Jun Yaung, Isabelle Lao-Ngo, Nathan M. Young, Reuben H. Kim, Ophir D. Klein, Ophir D. Klein, Christine Hong   +13 more
doaj   +1 more source

Pro Nerve Growth Factor and Its Receptor p75NTR Activate Inflammatory Responses in Synovial Fibroblasts: A Novel Targetable Mechanism in Arthritis

Frontiers in Immunology, 2022
We have recently provided new evidence for a role of p75NTR receptor and its preferential ligand proNGF in amplifying inflammatory responses in synovial mononuclear cells of chronic arthritis patients.
Luciapia Farina, Gaetana Minnone, Stefano Alivernini, Ivan Caiello, Lucy MacDonald, Marzia Soligo, Luigi Manni, Barbara Tolusso, Simona Coppola, Erika Zara, Libenzio Adrian Conti, Angela Aquilani, Silvia Magni-Manzoni, Mariola Kurowska-Stolarska, Elisa Gremese, Fabrizio De Benedetti, Fabrizio De Benedetti, Luisa Bracci-Laudiero, Luisa Bracci-Laudiero   +18 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

A p75NTR Pivoting Paradigm Propels Perspicacity [PDF]

, 2009
The p75 neurotrophin receptor (p75NTR) is involved in numerous neuronal signaling paths but its fundamental signaling mechanisms are unknown. In this issue of Neuron, Vilar et al.
Barker, Philip A.
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Knockdown of p75NTR surface expression in PC12 cells by the p75NTR-specific ER retained intrabodies.

, 2013
PC12 cells were transiently transfected with the p75NTR-specific ER retained intrabodies or αphOx-KDEL. Four days after transfection, the p75NTR surface expressions were determined with mouse anti-p75NTR mAb (MLR2, 1∶200) followed by goat anti-mouse IgG ...
Andrea L. J. Marschall (334275), Martin Korte (328234), Michael Hust (39229), Manuela Schüngel (334277), Saskia Helmsing (334271), Stefan Dübel (39230), Congcong Zhang (334270), Marta Zagrebelsky (334273), Thomas Schirrmann (39228)   +8 more
core   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Fast-diffusing p75NTR monomers support apoptosis and growth cone collapse by neurotrophin ligands [PDF]

, 2019
The p75 neurotrophin (NT) receptor (p75NTR) plays a crucial role in balancing survival-versus-death decisions in the nervous system. Yet, despite 2 decades of structural and biochemical studies, a comprehensive, accepted model for p75NTR activation by NT
Calvello, Mariantonietta, Jacob, Ajesh, Mariantonietta Calvello, Beltram, Fabio, Francesco Gobbo, Luin, Stefano, Laura Marchetti, Marchetti, Laura, Antonino Cattaneo, Porciani, David, Giovanni Signore, Mainardi, Marco, Bonsignore, Fulvio, Cattaneo, Antonino, Rosy Amodeo, Stefano Luin, Marco Mainardi, Signore, Giovanni, Gobbo, Francesco, Ajesh Jacob, David Porciani, Amodeo, Rosy, Fulvio Bonsignore, Fabio Beltram, Schirripa Spagnolo, Chiara, Chiara Schirripa Spagnolo   +25 more
core   +2 more sources

Untersuchungen über die funktionelle Rolle des Neurotrophinrezeptors p75NTR [PDF]

, 2002
Neurotrophine sind für die Entwicklung und Funktion des Nervensystems von Wirbeltieren unabdingbar. Sie entfalten ihre vielfältigen Funktionen über zwei Typen von Transmembranrezeptoren.
Schweigreiter, Rüdiger
core   +1 more source