Results 61 to 70 of about 14,094 (223)
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk +7 more
wiley +1 more source
eLife, 2020 Networks of neurons control feeding and activity patterns by integrating internal metabolic signals of energy balance with external environmental cues such as time-of-day.
Brandon Podyma +8 more
doaj +1 more source
Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]
, 2001 Nerve Growth Factor (NGF) signal transduction is involved in the survival, differentiation and maintenance of neurons through the receptors TrkA and p75NTR. These receptors activate downstream protein kinase cascades that regulate cell survival.
Clements, Shona Marie
core
Neurotrophin receptor p75NTR mediates Huntington's disease-associated synaptic and memory dysfunction [PDF]
, 2017 Learning and memory deficits are early clinical manifestations of Huntington's disease (HD). These cognitive impairments have been mainly associated with frontostriatal HD pathology; however, compelling evidence provided by several HD murine models ...
Alberch i Vié, Jordi +11 more
core +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
ASN Neuro, 2020 The p75 neurotrophin receptor (p75NTR) can regulate multiple cellular functions including proliferation, survival, and apoptotic cell death. The p75NTR is widely expressed in the developing brain and is downregulated as the nervous system matures, with ...
Laura E. Montroull +8 more
doaj +1 more source
Generation of mice with a conditional allele for the p75 NTR neurotrophin receptor gene [PDF]
, 2011 The p75 NTR neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understanding the physiologic role of p75 NTR , many details and aspects remain to be ...
Bogenmann, Emil +6 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Exercise‐induced increases in forearm venous plasma and serum brain‐derived neurotrophic factor (BDNF) are often assumed to be indicative of release from the brain. Sixteen healthy and physically fit adults (20–40 years old) were recruited to investigate whether exercise‐induced changes in forearm venous mature BDNF (mBDNF) and ...
Olga Tarassova +10 more
wiley +1 more source
Molecular and Structural Insight into proNGF Engagement of p75NTR and Sortilin [PDF]
Journal of Molecular Biology, 2010 Nerve growth factor (NGF) is initially synthesized as a precursor, proNGF, that is cleaved to release its C-terminal mature form. Recent studies suggested that proNGF is not an inactive precursor but acts as a signaling ligand distinct from its mature counterpart.
Dan, Feng +7 more
openaire +2 more sources
Common olfactory ensheathing glial markers in the developing human olfactory system [PDF]
, 2016 The in situ immunocytochemical properties of olfactory ensheathing cells (OECs) have been well studied in several small to medium sized animal models including rats, mice, guinea pigs, cats and canines.
Choi, D, Cotfas, D, Oprych, K
core +1 more source