Results 71 to 80 of about 9,698 (210)
Kinetics of the p75NTR knockdown effect in PC12 cells.
, 2013 PC12 cells were transiently transfected with SH325-G7-KDEL or the control αphOx-KDEL and harvested at different time points. The p75NTR surface expression levels were determined with mouse anti-p75NTR mAb (MLR2, 1∶200) followed by goat anti-mouse IgG F ...
Andrea L. J. Marschall (334275) +8 more
core +1 more source
Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen +1 more
wiley +1 more source
Oxidative Stress Induces p75NTR Signaling in Midbrain Dopaminergic Cells
, 2019 The p75 Neurotrophin Receptor (p75NTR) is a transmembrane protein with an established role in regulating the survival of neurons that have been impacted by an injury or neurological disorder. Injury to nervous tissue can result in cellular production and
Schemanski, Montana +5 more
core +1 more source
Molecular Therapy: Methods & Clinical Development, 2015 Accumulation of the nerve growth factor precursor (proNGF) and its receptor p75NTR have been associated with several neurodegenerative diseases in both brain and retina. However, whether proNGF contributes to microvascular degeneration remain unexplored.
Ahmed Y Shanab +3 more
doaj +1 more source
The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration
Orthopaedic Surgery, Volume 18, Issue 9, Page 1804-1818, September 2026.The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou +6 more
wiley +1 more source
Toluene Alters p75NTR Expression in the Rat Brainstem
INDUSTRIAL HEALTH, 2004 Toluene is a neurotoxic organic solvent widely used in industry. Acute toluene administration in rats induced a significant increase in the numbers of neural cells immunostained for p75NTR in several brainstem regions, such as the raphe magnus and the nucleus of the solitary tract, as well as in the lateral reticular, gigantocellular, vestibular and ...
PASCUAL, Jesús +5 more
openaire +3 more sources
CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.NAP2, a NgR1 antagonist peptide, improved cognition in APP/PS1 mice, reduced Aβ plaques and tau hyperphosphorylation, increased dendritic spine density, and alleviated mitochondrial damage, acting through inhibition of the Nogo‐A/NgR/ROCK pathway, highlighting its therapeutic potential for Alzheimer's disease.
Zheng Zhang +14 more
wiley +1 more source
Avaliação da expressão do receptor p75NTR em leucemia linfocítica aguda [PDF]
, 2016 A leucemia linfocítica aguda é o tumor pediátrico mais comum atualmente. Apesar do sucesso de protocolos de tratamento empregados atualmente, que consideram o risco de cada paciente e adotam o protocolo ideal, cerca de 30% dos pacientes são refratários ...
Dutra, Livia Fratini
core +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background Skeletal muscle dysfunction (SMD) is a common extrapulmonary complication of chronic obstructive pulmonary disease (COPD). Histone deacetylase 2 (HDAC2) is closely involved in the suppression of inflammatory transcription and is progressively reduced during COPD progression.
Chao Li +4 more
wiley +1 more source
Neurobiology of Disease, 2015 After nerve injury, Schwann cells (SCs) dedifferentiate, proliferate, and support axon regrowth. If axons fail to regenerate, denervated SCs eventually undergo apoptosis due, in part, to increased expression of the low-affinity neurotrophin receptor ...
Iram Ahmad +5 more
doaj +1 more source