Results 71 to 80 of about 14,094 (223)

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Toluene Alters p75NTR Expression in the Rat Brainstem

INDUSTRIAL HEALTH, 2004
Toluene is a neurotoxic organic solvent widely used in industry. Acute toluene administration in rats induced a significant increase in the numbers of neural cells immunostained for p75NTR in several brainstem regions, such as the raphe magnus and the nucleus of the solitary tract, as well as in the lateral reticular, gigantocellular, vestibular and ...
Jesús, Pascual, Lena, Morón, Jon, Zárate, Arantza, Gutiérrez, Itziar, Churruca, Enrique, Echevarría   +5 more
openaire   +3 more sources

Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation

Frontiers in Molecular Neuroscience, 2023
Despite structural similarity with other tumor necrosis factor receptor superfamily (TNFRSF) members, the p75 neurotrophin receptor (p75NTR, TNFR16) mediates pleiotropic biological functions not shared with other TNFRs.
Victor Danelon, Sarah C. Garret-Thomson, Steven C. Almo, Francis S. Lee, Barbara L. Hempstead   +4 more
doaj   +1 more source

Expression of CD90 and P75NTR stem cell markers in ameloblastomas : a possible role in their biological behavior [PDF]

, 2016
Multicystic and unicystic ameloblastomas are benign odontogenic tumors that present distinct biological behavior. The investigation of stem cells has become an important branch of tumor biology, with several studies addressing the possible role of these ...
Coelho, Carolinne Almeida, Cury, Sérgio Elias Vieira, Decurcio, Daniel de Almeida, Dias, Andrielle, Guerra, Eliete Neves, Mantesso, Andrea, Marques, Ana Elizia Mascarenhas, Silva, Brunno Santos de Freitas, Silva, Fernanda Paula Yamamoto   +8 more
core   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

Differences in the surface binding and endocytosis of neurotrophins by p75NTR

Molecular and Cellular Neuroscience, 2004
Neurotrophins transmit signals retrogradely from synapses to cell bodies by two different types of surface receptors, p75NTR and Trks. Compared to TrkA, the function of p75NTR in nerve growth factor (NGF) endocytosis is less clear, and it is unknown whether p75NTR by itself may internalize other neurotrophins besides NGF.
Saxena S, Howe CL, Cosgaya JM, Hu M, Weis J, Krüttgen A   +5 more
openaire   +5 more sources

Rabies Virus Hijacks and accelerates the p75NTR retrograde axonal transport machinery. [PDF]

PLoS Pathogens, 2014
Rabies virus (RABV) is a neurotropic virus that depends on long distance axonal transport in order to reach the central nervous system (CNS). The strategy RABV uses to hijack the cellular transport machinery is still not clear.
Shani Gluska, Eitan Erez Zahavi, Michael Chein, Tal Gradus, Anja Bauer, Stefan Finke, Eran Perlson   +6 more
doaj   +1 more source

Immunization against specific fragments of neurotrophin p75 receptor protects forebrain cholinergic neurons in the olfactory bulbectomized mice [PDF]

, 2016
Alzheimer's disease (AD) is characterized by progressive cognitive impairment associated with marked cholinergic neuron loss and amyloid-β (Aβ) peptide accumulation in the brain.
Bobkova, Natalia, Deev, Alexander, Koroev, Dmitry, Medvinskaya, Natalia, Nekrasov, Pavel, Nesterova, Inna, Samokhin, Alexander, Sengpiel, Frank, Tatarnikova, Olga, Volpina, Olga, Vorobyov, Vasily   +10 more
core   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Directed differentiation of human bone marrow stromal cells to fate-committed Schwann cells [PDF]

, 2017
Transplantation of oligodendrocyte precursors represents a potential therapy for myelin disorders but requires a safe and accessible cell source. Here we report the directed differentiation of neural progenitors derived from adult bone marrow stromal ...
Ao, Q, Cai, S, Chan, YS, Chang, RSK, Shea, GKH, Shum, DKY, Tam, KW, Tsui, YP   +7 more
core   +2 more sources