Results 91 to 100 of about 9,698 (210)

P75NTR activation limits CD21lo B cell subsets expansion in response to autoimmune-inducing challenges

iScience
Summary: Studies, including our own, suggest that p75NTR plays a pivotal role in immune regulation. Here, we aimed to uncover the role of p75NTR signaling in regulating CD21lo B cell subsets, which are known to facilitate autoimmune activity, and to ...
Cong Luo, An-Hui Zha, Ru-Yi Luo, Zhao-Lan Hu, Wei-Yun Shen, Ru-Ping Dai   +5 more
doaj   +1 more source

p75NTR receptor – role in cell growth and apoptosis

Postępy Higieny i Medycyny Doświadczalnej, 2012
 The neurotrophins play an important role in the development of the nervous system. These trophic factors affect the cells through the neurotrophin receptors Trk and p75NTR. Trk (tyrosine kinase receptor) mediated signaling promotes survival and growth, while p75NTR-mediated signaling promotes cell death.
openaire   +2 more sources

Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor

The Journal of Clinical Investigation, 2022
Cell surface receptors, ligands, and adhesion molecules underlie development, circuit formation, and synaptic function of the central nervous system and represent important therapeutic targets for many neuropathologies.
Nicholas C. Morano, Roshelle S. Smith, Victor Danelon, Ryan Schreiner, Uttsav Patel, Natalia G. Herrera, Carla Smith, Steven M. Olson, Michelle K. Laerke, Alev Celikgil, Scott J. Garforth, Sarah C. Garrett-Thomson, Francis S. Lee, Barbara L. Hempstead, Steven C. Almo   +14 more
doaj   +1 more source

Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats

Journal of Orthopaedic Surgery and Research
Background Fractures heal through a process that involves angiogenesis and osteogenesis but may also lead to non-union or delayed healing. Bone marrow mesenchymal stem cells (BMSCs) have been reported to play a pivotal role in bone formation and vascular
Zhifeng Wu, Yongming Yang, Ming Wang
doaj   +1 more source

The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2019
Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75NTR), which increased the affinity and ...
Juan P. Zanin, Laura E. Montroull, Marta Volosin, Wilma J. Friedman   +3 more
doaj   +1 more source

RABV travels faster and is more directed when transported with p75NTR.

, 2014
(A–C) Multi-channel live imaging of EGFP-RABV 2 hours after addition to distal axon compartment of DRG explant previously treated with a fluorescent antibody against p75NTR. Arrowheads: p75NTR-positive RABV puncta, scale bar = 10 µm.
Eitan Erez Zahavi (475928), Michael Chein (622919), Shani Gluska (622918), Tal Gradus (622920), Anja Bauer (563620), Eran Perlson (475929), Stefan Finke (563627)   +6 more
core   +1 more source

An antisense-long-noncoding-RNA modulates p75NTR expression levels during neuronal polarization

iScience
Summary: Proper polarization of newly generated neurons is a critical process for neural network formation and brain development. The pan-neurotrophin p75NTR receptor plays a key role in this process localizing asymmetrically in one of the ...
Veronica De Paolis, Nicoletta Paolillo, Tiziano Siri, Alessandra Grosso, Veronica Lorello, Cristina Spina, Gabriele Caporali, Federico La Regina, Beatrice Vignoli, Corinna Giorgi   +9 more
doaj   +1 more source

Suppression of neurite outgrowth by high-dose nerve growth factor is independent of functional p75NTR receptors

Neurobiology of Disease, 2004
We have previously demonstrated that high concentrations of nerve growth factor suppress neurite outgrowth from sensory neurons. Inhibition could be mediated by either the p75NTR or TrkA receptor.
Anna M. Conti, Stephen Brimijoin, Laurence J. Miller, Anthony J. Windebank   +3 more
doaj   +1 more source

The effect of a mutation in P75NTR on axon and oligodendrocyte development in mice across the lifespan

, 2014
We have characterized several aspects of axon development in mice with\ud a mutation in exon III of the p75NTR gene. The mutation results in deletion of the\ud extracellular ligand-binding domain.
Cain-Colonna, Rachel J.
core  

Deletion of p75NTR prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model

Scientific Reports, 2018
Ischemic retinopathy is characterized by ischemia followed by retinal neovascularization (RNV) resulting in visual impairment. Given the role of neuron-secreted growth factors in regulating angiogenesis, we examined how genetic deletion of the ...
Sally L. Elshaer, Azza B. El-Remessy
doaj   +1 more source