Results 91 to 100 of about 14,094 (223)

Peptide‐Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Peptide‐incorporated biomaterials provide precise, tunable biological cues that mimic functional protein domains to regulate behaviors of neurons, Schwann cells, immune cells, and endothelial cells, thereby enhancing axon elongation, Schwann cell support, inflammatory microenvironment modulation, and vascularization, offering a promising alternative to
Zhiwei Zhao, Jianfeng Liu, Jincheng Li, Di Li, Jianxun Ding, Bin Liu   +5 more
wiley   +1 more source

Merlin status regulates p75NTR expression and apoptotic signaling in Schwann cells following nerve injury

Neurobiology of Disease, 2015
After nerve injury, Schwann cells (SCs) dedifferentiate, proliferate, and support axon regrowth. If axons fail to regenerate, denervated SCs eventually undergo apoptosis due, in part, to increased expression of the low-affinity neurotrophin receptor ...
Iram Ahmad, Augusta Fernando, Richard Gurgel, J. Jason Clark, Linjing Xu, Marlan R. Hansen   +5 more
doaj   +1 more source

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons [PDF]

, 2019
Huntington\u27s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs).
Carrillo-Reid, Luis, Chan, C Savio, Chen, Yu, Day, Michelle, Guzman, Jaime N, Ilijic, Ema, Kaplitt, Michael, Kondapalli, Jyothisri, Kress, Geraldine J, Melendez, Alexandria E, Plotkin, Joshua L, Surmeier, D James, Wokosin, David L, Xie, Zhong   +13 more
core   +1 more source

Fragment C of Tetanus Toxin : New Insights into Its Neuronal Signaling Pathway [PDF]

, 2012
When Clostridium tetani was discovered and identified as a Gram-positive anaerobic bacterium of the genus Clostridium, the possibility of turning its toxin into a valuable biological carrier to ameliorate neurodegenerative processes was inconceivable ...
Acheson, Aguilera, Ana C. Calvo, Anderson, Barati, Boquet, Borasio, Bordet, Brooks, Calappi, Carlton, Chaib-Oukadour, Chaib-Oukadour, Check, Chen, Chen, Ciriza, Coen, Conway, Cosman, Cowie, Deinhardt, Deinhardt, Deinhardt, Emsley, Evinger, Firor, Fishman, Flexner, Fotinou, Gil, Gil, Gil, Gil, Habermann, Habermann, Harvey, Helting, Herreros, Herreros, Humeau, Inserte, Ipsen, Jayaraman, Jayaraman, Johnson, Johnson, Johnson, José Aguilera, Lalli, Landsteiner, Larsen, Lazarovici, Louch, Manning, Manwaring, Martini, Mendieta, Menestrina, Miana-Mena, Miana-Mena, Miana-Mena, Mochida, Montal, Moreno-Igoa, Moreno-Igoa, Neubauer, Noguchi, Oliveira, Pelliccioni, Pellizari, Pilar Zaragoza, Raquel Manzano, Roaf, Rosario Osta, Roux, Rummel, Sara Oliván, Sherrington, Siade, Simpson, Sinha, Skaper, Skeldal, Sugiyama, Sutton, Thorne, Twiss, Ungar, Van Heyningen, Van Heyningen, Van Heyningen, Van Heyningen, Wang, Wassermann, Wright   +95 more
core   +3 more sources

The Role of Dopamine Signaling and Neuroinflammation in Age‐Related Cognitive Dysfunction

Brain and Behavior, Volume 16, Issue 4, April 2026.
We reveal early disruption in synaptic integrity (PSD‐95, synaptophysin, BDNF), increased dopamine clearance (Comt, Net), and inflammatory signaling (Nfkb, Socs3) in the PFC, while the hippocampus remains largely resistant. These molecular “warning signs” precede behavioral deficits, highlighting potential targets for early intervention to protect ...
Junior Bowen, Katie Hanna, Andrew M. J. Young, Gisela Helfer, Samantha L. McLean   +4 more
wiley   +1 more source

p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate [PDF]

, 2008
The pan neurotrophin receptor p75(NTR) signals programmed cell death both during nervous system development and after neural trauma and disease in the adult. However, the molecular pathways by which death is mediated remain poorly understood.
Bartlett, P. F., Coulson, E. J., May, L. M., Meunier, F. A., Osborne, S. L., Reid, K., Sah, P., Underwood, C. K.   +7 more
core   +1 more source

Electroacupuncture Modulates Multiple Pathways for Neuroprotection and Neurorepair in Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
EA exerts therapeutic effects in ischemic stroke through multiple mechanisms: it alleviates acute injury by suppressing neuroinflammation, excitotoxicity, oxidative stress, apoptosis, pyroptosis, ferroptosis, autophagy dysregulation, and blood–brain barrier disruption, while enhancing cerebral blood flow, angiogenesis, and neurogenesis to support ...
Mingyue Zhao, Hangyu Shen, Xu Yan, Xiang Gao, Yuchun Liu, Shengjun Zhou, Jingxian Sun, Jie Sun, Yi Huang   +8 more
wiley   +1 more source

Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation. [PDF]

PLoS ONE, 2015
Gliogenesis under pathophysiological conditions is of particular clinical relevance since it may provide evidence for regeneration promoting cells recruitable for therapeutic purposes.
Kristel Kegler, Ingo Spitzbarth, Ilka Imbschweiler, Konstantin Wewetzer, Wolfgang Baumgärtner, Frauke Seehusen   +5 more
doaj   +1 more source

The p75NTR SIGNALING CASCADE MEDIATES MECHANICAL HYPERALGESIA INDUCED BY NERVE GROWTH FACTOR INJECTED INTO THE RAT HIND PAW [PDF]

, 2013
Nerve Growth Factor (NGF) augments excitability of isolated rat sensory neurons through activation of the p75 neurotrophin receptor (p75NTR) and its downstream sphingomyelin signaling cascade, wherein neutral sphingomyelinase(s) (nSMase), ceramide, and ...
Khodorova, Alla, Nicol, Grant D., Strichartz, Gary   +2 more
core   +1 more source

Novel insights into extracellular vesicles: An update on biomolecules, immunomodulation and clinical strategies in skin melanoma

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles mediate melanoma progression by transferring biomolecules (proteins, nucleic acids) that reshape the tumour microenvironment, promote immune evasion and drive metastasis. They also serve as diagnostic biomarkers and engineered therapeutic carriers for targeted therapy.
Junshu Li, Wencheng Zhou, Ying Cen, Yong Qing   +3 more
wiley   +1 more source