The functional and molecular roles of p75 neurotrophin receptor (p75) in epilepsy [PDF]
Journal of Central Nervous System DiseaseEpilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain.
Areej Turkistani +8 more
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Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation [PDF]
Frontiers in Molecular Neuroscience, 2023 Despite structural similarity with other tumor necrosis factor receptor superfamily (TNFRSF) members, the p75 neurotrophin receptor (p75NTR, TNFR16) mediates pleiotropic biological functions not shared with other TNFRs.
Victor Danelon +4 more
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The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons [PDF]
Frontiers in Cellular Neuroscience, 2019 Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75NTR), which increased the affinity and ...
Juan P. Zanin +3 more
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High-affinity TrkA and p75 neurotrophin receptor complexes: A twisted affair. [PDF]
J Biol Chem, 2022 Neurotrophin signaling is essential for normal nervous system development and adult function. Neurotrophins are secreted proteins that signal via interacting with two neurotrophin receptor types: the multifaceted p75 neurotrophin receptor and the ...
Conroy JN, Coulson EJ.
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Metabolic Control of Sensory Neuron Survival by the p75 Neurotrophin Receptor in Schwann Cells. [PDF]
J Neurosci, 2021 We report that the neurotrophin receptor p75 contributes to sensory neuron survival through the regulation of cholesterol metabolism in Schwann cells. Selective deletion of p75 in mouse Schwann cells of either sex resulted in a 30% loss of dorsal root ...
Follis RM +9 more
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Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor. [PDF]
Aging Cell, 2021 The plasticity mechanisms in the nervous system that are important for learning and memory are greatly impacted during aging. Notably, hippocampal‐dependent long‐term plasticity and its associative plasticity, such as synaptic tagging and capture (STC ...
Wong LW +6 more
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p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial. [PDF]
Nat Medp75 neurotrophin receptor (p75NTR) signaling pathways substantially overlap with degenerative networks active in Alzheimer disease (AD). Modulation of p75NTR with the first-in-class small molecule LM11A-31 mitigates amyloid-induced and pathological tau ...
Shanks HRC +9 more
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Signaling via the p75 neurotrophin receptor facilitates amyloid-β-induced dendritic spine pathology. [PDF]
Sci Rep, 2020 Synapse and dendritic spine loss induced by amyloid-β oligomers is one of the main hallmarks of the early phases of Alzheimer’s disease (AD) and is directly correlated with the cognitive decline typical of this pathology.
Patnaik A +3 more
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A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. [PDF]
Brain : a journal of neurology, 2016 The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine +20 more
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Neurotrophin receptor p75 mediates amyloid β-induced tau pathology
Neurobiology of Disease, 2019 Neurofibrillary tangles of hyperphosphorylated tau protein (p-tau) are a key pathological feature of Alzheimer's disease (AD). Tau phosphorylation is suggested to be secondary to amyloid-beta (Aβ) accumulation.
Lin-Lin Shen +14 more
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