Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation [PDF]
Frontiers in Molecular Neuroscience, 2023 Despite structural similarity with other tumor necrosis factor receptor superfamily (TNFRSF) members, the p75 neurotrophin receptor (p75NTR, TNFR16) mediates pleiotropic biological functions not shared with other TNFRs.
Victor Danelon +4 more
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The functional and molecular roles of p75 neurotrophin receptor (p75) in epilepsy [PDF]
Journal of Central Nervous System DiseaseEpilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain.
Areej Turkistani +8 more
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The new wave of p75 neurotrophin receptor targeted therapies [PDF]
Neural Regeneration Research, 2022 Amanda M Crooks, Rick B Meeker
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The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons [PDF]
Frontiers in Cellular Neuroscience, 2019 Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75NTR), which increased the affinity and ...
Juan P. Zanin +3 more
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The extracellular domain of neurotrophin receptor p75 as a candidate biomarker for amyotrophic lateral sclerosis. [PDF]
PLoS ONE, 2014 Objective biomarkers for amyotrophic lateral sclerosis would facilitate the discovery of new treatments. The common neurotrophin receptor p75 is up regulated and the extracellular domain cleaved from injured neurons and peripheral glia in amyotrophic ...
Stephanie R Shepheard +4 more
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Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin [PDF]
Biomedicines, 2020 Schwann cells (SCs) are the main glial cells of the peripheral nervous system (PNS) and are known to be involved in various pathophysiological processes, such as diabetic neuropathy and nerve regeneration, through neurotrophin signaling.
Nádia P. Gonçalves +7 more
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Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. [PDF]
PLoS Biology, 2008 The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP)
LiMei Wang +8 more
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Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor [PDF]
The Journal of Clinical Investigation, 2022 Cell surface receptors, ligands, and adhesion molecules underlie development, circuit formation, and synaptic function of the central nervous system and represent important therapeutic targets for many neuropathologies.
Nicholas C. Morano +14 more
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p75 neurotrophin receptor regulates craniofacial growth and morphology in postnatal development [PDF]
Frontiers in Cell and Developmental BiologyCraniofacial abnormalities are among the most prevalent congenital defects, significantly affecting appearance, function, and quality of life. While the role of genetic mutations in craniofacial malformations is recognized, the underlying molecular ...
Byron Zhao +13 more
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Modulation of p75 neurotrophin receptor mitigates brain damage following ischemic stroke in mice [PDF]
Neural Regeneration ResearchGolnoush Mirzahosseini, Tauheed Ishrat
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