p75 Neurotrophin Receptor Regulates Energy Balance in Obesity [PDF]
Cell Reports, 2016 Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD).
Bernat Baeza-Raja +16 more
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Retrograde apoptotic signaling by the p75 neurotrophin receptor. [PDF]
Neuronal Signal, 2017 Neurotrophins are target-derived factors necessary for mammalian nervous system development and maintenance. They are typically produced by neuronal target tissues and interact with their receptors at axonal endings.
Pathak A, Carter BD.
europepmc +5 more sources
The p75 neurotrophin receptor: at the crossroad of neural repair and death
Neural Regeneration Research, 2015 The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease. However, difficulties with the clinical implementation
Rick B Meeker, Kimberly S Williams
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The new wave of p75 neurotrophin receptor targeted therapies [PDF]
Neural Regeneration Research, 2022 Amanda M Crooks, Rick B Meeker
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Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor
Cell Reports, 2012 Structural determinants underlying signaling specificity in the tumor necrosis factor receptor superfamily (TNFRSF) are poorly characterized, and it is unclear whether different signaling outputs can be genetically dissociated.
Ioannis Charalampopoulos +5 more
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The p75 neurotrophin receptor is a central regulator of glioma invasion. [PDF]
PLoS Biology, 2007 The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional therapies.
Angela L M Johnston +10 more
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Modulation of Small RNA Signatures in Schwann-Cell-Derived Extracellular Vesicles by the p75 Neurotrophin Receptor and Sortilin [PDF]
Biomedicines, 2020 Schwann cells (SCs) are the main glial cells of the peripheral nervous system (PNS) and are known to be involved in various pathophysiological processes, such as diabetic neuropathy and nerve regeneration, through neurotrophin signaling.
Nádia P. Gonçalves +7 more
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Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells [PDF]
Frontiers in Immunology, 2017 Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the
Joanna Bandoła +19 more
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Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model. [PDF]
Aging (Albany NY), 2019 p75 neurotrophin receptor (p75NTR) has been implicated in Alzheimer’s disease (AD). However, whether p75NTR is involved in Tau hyperphosphorylation, one of the pathologies observed in AD, remains unclear.
Mañucat-Tan NB +6 more
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Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor [PDF]
The Journal of Clinical Investigation, 2022 Cell surface receptors, ligands, and adhesion molecules underlie development, circuit formation, and synaptic function of the central nervous system and represent important therapeutic targets for many neuropathologies.
Nicholas C. Morano +14 more
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