Results 11 to 20 of about 1,248,941 (203)

The p75 neurotrophin receptor: at the crossroad of neural repair and death

Neural Regeneration Research, 2015
The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA, TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury and disease. However, difficulties with the clinical implementation
Rick B Meeker, Kimberly S Williams
doaj   +4 more sources

The p75 neurotrophin receptor is a central regulator of glioma invasion. [PDF]

PLoS Biology, 2007
The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional therapies.
Angela L M Johnston, Xueqing Lun, Jennifer J Rahn, Abdelhamid Liacini, Limei Wang, Mark G Hamilton, Ian F Parney, Barbara L Hempstead, Stephen M Robbins, Peter A Forsyth, Donna L Senger   +10 more
doaj   +5 more sources

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity [PDF]

Cell Reports, 2016
Obesity and metabolic syndrome reflect the dysregulation of molecular pathways that control energy homeostasis. Here, we show that the p75 neurotrophin receptor (p75NTR) controls energy expenditure in obese mice on a high-fat diet (HFD).
Bernat Baeza-Raja, Benjamin D. Sachs, Pingping Li, Frank Christian, Eirini Vagena, Dimitrios Davalos, Natacha Le Moan, Jae Kyu Ryu, Shoana L. Sikorski, Justin P. Chan, Miriam Scadeng, Susan S. Taylor, Miles D. Houslay, George S. Baillie, Alan R. Saltiel, Jerrold M. Olefsky, Katerina Akassoglou   +16 more
doaj   +9 more sources

The p75 neurotrophin receptor

The International Journal of Biochemistry & Cell Biology, 2008
The pan neurotrophin receptor (p75(NTR)) is best known for mediating neural cell death during development as well as in the adult following injury, the latter making it a target for the treatment of neurodegenerative disease. Although p75(NTR) has been studied for over 30 years, a number of recent discoveries have changed our understanding of its ...
Underwood, Clare K., Coulson, Elizabeth J.   +1 more
openaire   +6 more sources

Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor

Cell Reports, 2012
Structural determinants underlying signaling specificity in the tumor necrosis factor receptor superfamily (TNFRSF) are poorly characterized, and it is unclear whether different signaling outputs can be genetically dissociated.
Ioannis Charalampopoulos, Annalisa Vicario, Iosif Pediaditakis, Achille Gravanis, Anastasia Simi, Carlos F. Ibáñez   +5 more
doaj   +4 more sources

Inactivation and activation of Ras by the neurotrophin receptor p75

European Journal of Neuroscience, 2004
AbstractThe neurotrophin receptor p75 induces neurotrophic and/or apoptotic signalling pathways and can also cooperate with the neurotrophic Trk receptor tyrosine kinases. Its intracellular part encloses a so‐called ‘death domain’ with a segment similar to the wasp venom mastoparan which binds small GTPases such as Rho.
Blöchl, A., Blumenstein, L., Ahmadian, M.   +2 more
openaire   +5 more sources

Nuclear Localization of the p75 Neurotrophin Receptor Intracellular Domain [PDF]

Journal of Biological Chemistry, 2010
The p75 neurotrophin receptor, a member of the tumor necrosis factor superfamily of receptors, undergoes an alpha-secretase-mediated release of its extracellular domain, followed by a gamma-secretase-mediated intramembrane cleavage. Like amyloid precursor protein and Notch, gamma-secretase cleavage of the p75 receptor releases an intracellular domain ...
Christopher N, Parkhurst, Niccoló, Zampieri, Moses V, Chao   +2 more
openaire   +3 more sources

Structural basis of death domain signaling in the p75 neurotrophin receptor

eLife, 2015
Death domains (DDs) mediate assembly of oligomeric complexes for activation of downstream signaling pathways through incompletely understood mechanisms.
Zhi Lin, Jason Y Tann, Eddy TH Goh, Claire Kelly, Kim Buay Lim, Jian Fang Gao, Carlos F Ibanez   +6 more
doaj   +2 more sources

p75 neurotrophin receptor distribution and transport in cultured neurons

Neuroscience Research, 2008
In this work, we define a GFP-tagged version of the p75 neurotrophin receptor (p75GFP) as a useful molecular tool for studying its distribution and cellular dynamics. Expression and subcellular localization of p75GFP have been characterized in non-neuronal (HEK 293) and in neuronal (cortical and hippocampal) cells.
FORMAGGIO, Elena, CANTÙ, Cinzia, CHIAMULERA, Cristiano, FUMAGALLI, Guido Francesco   +3 more
core   +5 more sources

Association of the p75 Neurotrophin Receptor with TRAF6 [PDF]

Journal of Biological Chemistry, 1999
In addition to the Trk tyrosine kinase receptors, neurotrophins also bind to a second receptor, p75, a member of the tumor necrosis factor receptor superfamily. Several signaling pathways have been implicated for p75 in the absence of Trk receptors, including induction of NF-kappaB and c-Jun kinase activities and increased production of ceramide ...
G, Khursigara, J R, Orlinick, M V, Chao
openaire   +2 more sources