Results 31 to 40 of about 1,248,941 (203)

P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1

Neurobiology of Disease, 2005
Our recent transcriptome profiling studies suggest that presenilin 1 (PS1) regulates expression of neural cell adhesion molecule (Ncam1) through p75 neurotrophin receptor.
Zeljka Korade Mirnics, Chaohua Yan, Carmel Portugal, Tae-Wan Kim, H. Uri Saragovi, Sangram S. Sisodia, Karoly Mirnics, Nina F. Schor   +7 more
doaj   +1 more source

Structural characterization of the self-association of the death domain of p75(NTR.). [PDF]

PLoS ONE, 2013
The neurotrophin receptor p75(NTR) conveys multiple signals via its intracellular death domain. However, how the death domain is activated and interacts with downstream adaptors remains unclear.
Qianhui Qu, Jun Chen, Yizhi Wang, Wenjun Gui, Li Wang, Zusen Fan, Tao Jiang   +6 more
doaj   +1 more source

Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons [PDF]

, 2002
Signaling by brain-derived neurotrophic factor (BDNF) via the TrkB receptor, or by neurotrophin-3 (NT3) through the TrkC receptor support distinct populations of sensory neurons.
Schimmang, Thomas, Lewin, G. R., Lewin, Gary R, Klein, R.*, Klein, R., Lewin, G.R., Fritzsch, B., Minichiello, L.*, Calella, A. M., Minichiello, Liliana, Klein, Rüdiger, Katz, David, Eilers, A., Schimmang, T., Minichiello, L., Lewin, G., Katz, D., Postigo, A., Calella, A.M., *Corresponding authors, Calella, A., Fritzsch, Bernd, Knipper, M., Postigo, Antonio, Eilers, Andreas, Calella, Anna Maria, Knipper, Marlies   +26 more
core   +1 more source

Neurotrophin receptor p75 mediates amyloid β-induced tau pathology

Neurobiology of Disease, 2019
Neurofibrillary tangles of hyperphosphorylated tau protein (p-tau) are a key pathological feature of Alzheimer's disease (AD). Tau phosphorylation is suggested to be secondary to amyloid-beta (Aβ) accumulation.
Lin-Lin Shen, Wei-Wei Li, Ya-Li Xu, Shi-Hao Gao, Man-Yu Xu, Xian-Le Bu, Yu-Hui Liu, Jun Wang, Jie Zhu, Fan Zeng, Xiu-Qing Yao, Chang-Yue Gao, Zhi-Qiang Xu, Xin-Fu Zhou, Yan-Jiang Wang   +14 more
doaj   +1 more source

Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition

Redox Biology, 2021
Emerging evidence suggests that the reduction of ethanolamine plasmalogen (PlsEtn) is associated with in Alzheimer's disease and metabolic diseases. However, the mechanistic bases for PlsEtn on the these diseases are not well understood. Plasmalogens are
Yanjun Liu, Peixu Cong, Tao Zhang, Rui Wang, Xiaoxu Wang, Junyi Liu, Xinceng Wang, Jie Xu, Yuming Wang, Jingfeng Wang, Changhu Xue   +10 more
doaj   +1 more source

BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons

eLife, 2023
Brain-derived neurotrophic factor (BDNF) and its receptors tropomyosin kinase receptor B (TrkB) and the p75 neurotrophin receptor (p75) are the primary regulators of dendritic growth in the CNS.
Guillermo Moya-Alvarado, Reynaldo Tiburcio-Felix, María Raquel Ibáñez, Alejandro A Aguirre-Soto, Miguel V Guerra, Chengbiao Wu, William C Mobley, Eran Perlson, Francisca C Bronfman   +8 more
doaj   +1 more source

A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor [PDF]

Cell Death & Differentiation, 1999
The p75 neurotrophic receptor (p75) shares structural features with the Fas receptor (FasR). Both receptors contain extracellular cysteine-rich repeats, a single transmembrane domain, and intracellular death domains. However, it has not been clearly established whether their death domains are equivalent in their ability to mediate apoptosis.
H, Kong, A H, Kim, J R, Orlinick, M V, Chao   +3 more
openaire   +2 more sources

In vivo function of NGF/TrkA signaling in the cholinergic neurons of the murine basal forebrain [PDF]

, 2005
The neurotrophins are a family of secreted proteins that potently regulate diverse neuronal responses. The neurotrophin nerve growth factor (NGF) and its receptors TrkA and p75 are well characterized to control survival, differentiation and function of ...
Mueller, Markus
core   +1 more source

Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers [PDF]

, 2009
Ligand-mediated dimerization has emerged as a universal mechanism of growth factor receptor activation. Neurotrophins interact with dimers of the p75 neurotrophin receptor (p75(NTR)), but the mechanism of receptor activation has remained elusive.
Alessandra Reversi, Soyoung Choi, Vilar, M., Ibañez, C., Friedman, W., Ioannis Charalampopoulos, Charalampopoulos, I., Carter, Bruce D., Kenchappa, R., reversi, Alessandra, Karaca, E., Rajappa S. Kenchappa, Bastiaens, P., Mark Bothwell, Anastasia Simi, Marçal Vilar, Ismael Mingarro, Simi, A., Friedman, Wilma J., Wilma J. Friedman, Philippe I.H. Bastiaens, Mingarro, Ismael, Verveer, Peter J., Mingarro Muñoz, Ismael, Vilar, Marçal, Verveer, P., Giampietro Schiavo, Karaca, Esra, Bastiaens, Philippe I. H., Ibañez, Carlos F., Kenchappa, Rajappa S., Choi, S., Carlos F. Ibáñez, Simi, Anastasia, Peter J. Verveer, Bruce D. Carter, Bothwell, Mark, Charalampopoulos, Ioannis, reversi, A., Bastiaens, Philippe I.H., Charalampopoulos, Iaonnis, Mingarro, I., Bothwell, M., Choi, Soyoung, Schiavo, Giampietro, Schiavo, G., Esra Karaca, Carter, B.   +47 more
core   +1 more source

A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury [PDF]

, 2016
The p75 neurotrophin receptor is important in multiple physiological actions including neuronal survival and neurite outgrowth during development, and after central nervous system injury.
Alam, Antoine, Arnone, Michele, Lee, Sangmi, Lin, Amity, Manley, Geoffrey T, Savi, Pierre, Delbary-Gossart, Sandrine, Sacramento, Jeffrey, Ferzaz, Badia, Bresnahan, Jacqueline C, Ferguson, Adam R, Beattie, Michael S, Canolle, Benoit, Castel, Marie-Noelle, Laboudie, Patricia, Salegio, Ernesto A, Delesque-Touchard, Nathalie, Lamarche, Isabelle, Baroni, Marco, Bono, Françoise, Herbert, Jean-Marc   +20 more
core   +1 more source