Results 51 to 60 of about 25,950 (247)
Scientific Reports, 2019 Age-related degeneration of basal forebrain cholinergic neurons (BFCNs) is linked to cognitive impairment. The p75 neurotrophin receptor (p75NTR) has been proposed to mediate neuronal degeneration in aging.
Youmei Xie +3 more
semanticscholar +1 more source
Redox Biology, 2021 Emerging evidence suggests that the reduction of ethanolamine plasmalogen (PlsEtn) is associated with in Alzheimer's disease and metabolic diseases. However, the mechanistic bases for PlsEtn on the these diseases are not well understood. Plasmalogens are
Yanjun Liu +10 more
doaj +1 more source
Immunization against specific fragments of neurotrophin p75 receptor protects forebrain cholinergic neurons in the olfactory bulbectomized mice [PDF]
, 2016 Alzheimer's disease (AD) is characterized by progressive cognitive impairment associated with marked cholinergic neuron loss and amyloid-β (Aβ) peptide accumulation in the brain.
Bobkova, Natalia +10 more
core +1 more source
The role of p75NTR in cholinergic basal forebrain structure and function [PDF]
, 2014 The role of the p75 neurotrophin receptor (p75NTR) in adult cholinergic basal forebrain (cBF) neurons is unclear due to conflicting results from previous studies and to limitations of existing p75NTR-knock-out mouse models. In the present study we used a
Alfonsi, Fabienne +5 more
core +1 more source
A comparison of the cytoplasmic domains of the Fas receptor and the p75 neurotrophin receptor [PDF]
Cell Death & Differentiation, 1999 The p75 neurotrophic receptor (p75) shares structural features with the Fas receptor (FasR). Both receptors contain extracellular cysteine-rich repeats, a single transmembrane domain, and intracellular death domains. However, it has not been clearly established whether their death domains are equivalent in their ability to mediate apoptosis.
H, Kong +3 more
openaire +2 more sources
The effects of short-term JNK inhibition on the survival and growth of aged sympathetic neurons [PDF]
, 2016 During the course of normal aging, certain populations of nerve growth factor (NGF)-responsive neurons become selectively vulnerable to cell death. Studies using dissociated neurons isolated from neonates have shown that c-Jun N-terminal kinases (JNKs ...
Al-Shawi, R +7 more
core +1 more source
Molecular Brain, 2018 Alzheimer disease (AD) is a complex pathology related to multiple causes including oxidative stress. Brain-derived neurotrophic factor (BDNF) is a neutrotrophic factor essential for the survival and differentiation of neurons and is considered a key ...
Catherine Fleitas +7 more
semanticscholar +1 more source
Generation of mice with a conditional allele for the p75 NTR neurotrophin receptor gene [PDF]
, 2011 The p75 NTR neurotrophin receptor has been implicated in multiple biological and pathological processes. While significant advances have recently been made in understanding the physiologic role of p75 NTR , many details and aspects remain to be ...
Bogenmann, Emil +6 more
core +1 more source
Free Radical Biology & Medicine, 2018 Circadian clock genes regulate energy metabolism partly through neurotrophins in the body. The low affinity neurotrophin receptor p75NTR is a clock component directly regulated by the transcriptional factor Clock:Bmal1 complex. Brain-derived neurotrophic
T. Ishii, E. Warabi, G. Mann
semanticscholar +1 more source
Localization of TrkB and p75 receptors in peritoneal and deep infiltrating endometriosis: an immunohistochemical study [PDF]
, 2016 BACKGROUND: The roles of the neurotrophins NGF (Neurotrophic growth factor) and BDNF (brain-derived neurotrophic factor) in neuronal growth and development are already known. Meanwhile, the neurotrophin receptors TrkA (tropomyosin related kinase A), TrkB,
Agung Dewanto +6 more
core +1 more source