Results 51 to 60 of about 1,248,941 (203)

An antisense-long-noncoding-RNA modulates p75NTR expression levels during neuronal polarization

iScience
Summary: Proper polarization of newly generated neurons is a critical process for neural network formation and brain development. The pan-neurotrophin p75NTR receptor plays a key role in this process localizing asymmetrically in one of the ...
Veronica De Paolis, Nicoletta Paolillo, Tiziano Siri, Alessandra Grosso, Veronica Lorello, Cristina Spina, Gabriele Caporali, Federico La Regina, Beatrice Vignoli, Corinna Giorgi   +9 more
doaj   +1 more source

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

PLoS ONE, 2008
The p75 neurotrophin receptor (p75(NTR)) is expressed by neurons particularly vulnerable in Alzheimer's disease (AD). We tested the hypothesis that non-peptide, small molecule p75(NTR) ligands found to promote survival signaling might prevent Abeta ...
Tao Yang, Juliet K Knowles, Qun Lu, Hong Zhang, Ottavio Arancio, Laura A Moore, Timothy Chang, Qian Wang, Katrin Andreasson, Jayakumar Rajadas, Gerald G Fuller, Youmei Xie, Stephen M Massa, Frank M Longo   +13 more
doaj   +1 more source

Chronic nerve growth factor exposure increases apoptosis in a model of in vitro induced conjunctival myofibroblasts. [PDF]

PLoS ONE, 2012
In the conjunctiva, repeated or prolonged exposure to injury leads to tissue remodeling and fibrosis associated with dryness, lost of corneal transparency and defect of ocular function.
Alessandra Micera, Ilaria Puxeddu, Bijorn Omar Balzamino, Stefano Bonini, Francesca Levi-Schaffer   +4 more
doaj   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Inflammatory Cytokines IL-1 and TNF- Regulate p75 Expression in CNS Neurons and Astrocytes by Distinct Cell-Type-Specific Signalling Mechanisms

ASN Neuro, 2009
The p75 NTR (where NTR is neurotrophin receptor) can mediate many distinct cellular functions, including cell survival and apoptosis, axonal growth and cell proliferation, depending on the cellular context.
Soyoung Choi, Wilma J Friedman
doaj   +1 more source

Laponite Network Controls FGF‐2 Release and Drives Functional Nerve Regeneration via 3D‐Printed Nerve Wrap Interfaces

Small Methods, EarlyView.
We developed a 3D‐printed nerve interface integrating a biomimetic nanocomposite hydrogel with sustained delivery of thermostable FGF‐2. The bioactive interface supports Schwann cell activity and myelination while providing a regenerative microenvironment.
Diego N. Rodriguez‐Sanchez, Akshat Joshi, Saeed Safari, Leticia A. M. de Carvalho, Kevin S. Muller, Uijin Kim, Luciana P. Cartarozzi, Meenakshi Kamaraj, Menekse Ermis, Natan R. de Barros, Alexandre L. R. de Oliveira   +10 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Pro-neurotrophins secreted from retinal ganglion cell axons are necessary for ephrinA-p75^NTR-mediated axon guidance

Neural Development, 2010
Background Retinotectal map formation develops via topographically specific guidance and branching of retinal axons in their target area. This process is controlled, in part, by reverse signalling of ephrinAs expressed on retinal axons.
Broom Emma R, Poopalasundaram Subathra, Marler Katharine JM, Wentzel Corinna, Drescher Uwe   +4 more
doaj   +1 more source

The role of brain derived neurotrophic factor in central nervous system

Frontiers in Aging Neuroscience, 2022
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological
Yiyi Li, Yiyi Li, Fang Li, Fang Li, Dongdong Qin, Dongdong Qin, Hongyu Chen, Hongyu Chen, Jianhao Wang, Jianhao Wang, Jiabei Wang, Jiabei Wang, Shafei Song, Shafei Song, Chao Wang, Chao Wang, Yamei Wang, Yamei Wang, Songyan Liu, Songyan Liu, Dandan Gao, Dandan Gao, Zhi-Hao Wang, Zhi-Hao Wang   +23 more
doaj   +1 more source