Results 61 to 70 of about 1,248,941 (203)

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit. [PDF]

PLoS ONE, 2013
Enduring reorganization is accepted as a fundamental process of adult neural plasticity. The most dramatic example of this reorganization is the birth and continuously occurring incorporation of new neurons into the pre-existing network of the adult ...
Franziska Neuser, Martin Polack, Christine Annaheim, Kerry L Tucker, Martin Korte   +4 more
doaj   +1 more source

Inhibition of Tropomyosin Receptor Kinase B Signaling Alters Hepatic Mitochondrial Enzyme Activity and Oxidative Stress in Mice With Sucrose‐Induced Insulin Resistance

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Suppression of BDNF‐TrkB signaling has shown a protective trend on hepatic oxidative stress by reducing sucrose‐induced lipid peroxidation. BDNF–TrkB signaling pathway plays a peripheral role in regulating mitochondrial enzyme capacity and redox balance in the liver.
Akın Bodur, Hüseyin Çınar Zihni, Katip Korkmaz, Solmaz Bodur, Ahmet Alver   +4 more
wiley   +1 more source

Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation [PDF]

Anesthesiology, 2012
Background Propofol exposure to neurons during synaptogenesis results in apoptosis, leading to cognitive dysfunction in adulthood. Previous work from our laboratory showed that isoflurane neurotoxicity occurs through p75 neurotrophin receptor (p75(NTR)) and subsequent cytoskeleton depolymerization.
Matthew L, Pearn, Yue, Hu, Ingrid R, Niesman, Hemal H, Patel, John C, Drummond, David M, Roth, Katerina, Akassoglou, Piyush M, Patel, Brian P, Head   +8 more
openaire   +2 more sources

Molecular Mediators Associated With Myelination, Demyelination, and Remyelination in the Peripheral Nervous System

Journal of the Peripheral Nervous System, Volume 31, Issue 3, September 2026.
ABSTRACT The peripheral nervous system (PNS) is responsible for innervating all regions of the body outside of the central nervous system (CNS), the latter consisting of the brain, spinal cord, and optic nerves. While myelin is an essential component for the efficient functioning of both CNS and peripheral nerve cells, it is particularly important for ...
Kathleen Margaret Hagen, Shalina Sheryl Ousman   +1 more
wiley   +1 more source

p75 Neurotrophin Receptor Suppresses the Proliferation of Human Gastric Cancer Cells

Neoplasia: An International Journal for Oncology Research, 2007
Identifying an effective therapeutic target is pivotal in the treatment of gastric cancer. In this study, we investigated the expression of p75 neurotrophin receptor (p75NTR) in gastric cancer and the impact of its alteration on tumor growth.
Haifeng Jin, Yanglin Pan, Lina Zhao, Huihong Zhai, Xiaohua Li, Li Sun, Lijie He, Yu Chen, Liu Hong, Yulei Du, Daiming Fan   +10 more
doaj   +1 more source

The High‐Intensity Zone: A Dynamic Inflammatory Hub in Lumbar Disc Degeneration

Orthopaedic Surgery, Volume 18, Issue 9, Page 1804-1818, September 2026.
The HIZ, a dynamic inflammatory hub in lumbar disc degeneration, links inflammation‐degeneration‐pain; integrating advanced diagnostics and targeted therapies offers precise management for discogenic low back pain. ABSTRACT The lumbar intervertebral disc high‐intensity zone (HIZ), a focal hyperintensity within the annulus fibrosus on T2‐weighted ...
Qi Zhou, Jingyi Cai, Weijian Zhu, Sirui Zhou, Liling Zhou, Yiyao Pei, Gang Wu   +6 more
wiley   +1 more source

Nuclear Translocation of the p75 Neurotrophin Receptor Cytoplasmic Domain in Response to Neurotrophin Binding [PDF]

The Journal of Neuroscience, 2005
The intracellular domain of the p75 neurotrophin receptor (p75ICD) can be released by γ-secretase in response to the previous activation of α-secretase by phorbol esters. However, ligand-dependent release of p75ICDhas yet to be described. We show here that nerve growth factor can induce the release of p75ICDand facilitate its translocation to the ...
openaire   +3 more sources

The neurotrophin receptor p75 binds neurotrophin-3 on sympathetic neurons with high affinity and specificity

, 1997
High-affinity neurotrophin-3 (NT3) receptors have been identified on nerve growth factor (NGF)-dependent sympathetic neurons, but their occupancy by NT3 does not lead to neuronal survival.
Barde, Y. A., Pantelis Tsoulfas, Yves-Alain Barde, Tsoulfas, Pantelis, Barde, Yves-Alain, Parada, L. F., Georg Dechant, Parada, Luis F, Tsoulfas, P., Luis F. Parada, Dechant, Georg, Dechant, G.   +11 more
core   +1 more source

Neurotrophin receptors expression and JNK pathway activation in human astrocytomas

BMC Cancer, 2007
Background Neurotrophins are growth factors that regulate cell growth, differentiation and apoptosis in the nervous system. Their diverse actions are mediated through two different transmembrane – receptor signaling systems: Trk receptor tyrosine kinases
Maraziotis Theodore, Gatzounis George, Kondyli Maria, Assimakopoulou Martha, Varakis John   +4 more
doaj   +1 more source