Results 61 to 70 of about 25,950 (247)

The potential role of the p75 receptor in schizophrenia: neuroimmunomodulation and making life or death decisions

open access: yesBrain, Behavior, & Immunity - Health
The nerve growth factor receptor, also referred to as tumour necrosis factor II and the p75 neurotrophin receptor (p75), serves pleiotropic functions in both the peripheral and central nervous system, involving modulation of immune responses, cell ...
Jessica Chandra
doaj   +1 more source

p75 Neurotrophin Receptor: A Double-Edged Sword in Pathology and Regeneration of the Central Nervous System

open access: yesVeterinary Pathology-Supplement, 2018
The low-affinity nerve growth factor receptor p75NTR is a major neurotrophin receptor involved in manifold and pleiotropic functions in the developing and adult central nervous system (CNS).
K. Becker   +3 more
semanticscholar   +1 more source

Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilin in colorectal cancer cell survival.

open access: yesPLoS ONE, 2011
BackgroundNeurotrophin receptors were initially identified in neural cells. They were recently detected in some cancers in association with invasiveness, but the function of these tyrosine kinase receptors was not previously investigated in colorectal ...
Hussein Akil   +4 more
doaj   +1 more source

Etiological Roles of p75NTR in a Mouse Model of Wet Age-Related Macular Degeneration

open access: yesCells, 2023
Choroidal neovascularization (CNV) is a pathological angiogenesis of the choroidal plexus of the retina and is a key feature in the wet form of age-related macular degeneration.
Paula Virginia Subirada   +7 more
doaj   +1 more source

Functional Diversity of Neurotrophin Actions on the Oculomotor System [PDF]

open access: yes, 2016
Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes.
Benítez Temiño, Beatriz   +5 more
core   +1 more source

Retrograde degenerative signaling mediated by the p75 neurotrophin receptor requires p150Glued deacetylation by axonal HDAC1

open access: yesDevelopmental Cell, 2018
Summary During development, neurons undergo apoptosis if they do not receive adequate trophic support from tissues they innervate or when detrimental factors activate the p75 neurotrophin receptor (p75NTR) at their axon ends.
Amrita Pathak   +13 more
semanticscholar   +1 more source

p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes. [PDF]

open access: yes, 2011
p75 neurotrophin receptor (p75NTR) belongs to the TNF-receptor superfamily and signals apoptosis in many cell settings. In human epidermis, p75NTR is mostly confined to the transit-amplifying (TA) sub-population of basal keratinocytes.
DALLAGLIO, Katiuscia   +9 more
core   +1 more source

Sortilin participates in light-dependent photoreceptor degeneration in vivo.

open access: yesPLoS ONE, 2012
Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination.
Ana M Santos   +5 more
doaj   +1 more source

p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling

open access: yesCell Reports, 2017
Producing the neuronal diversity required to adequately discriminate all elements of somatosensation is a complex task during organogenesis. The mechanisms guiding this process during dorsal root ganglion (DRG) sensory neuron specification remain poorly ...
Zhijiang Chen   +8 more
doaj   +1 more source

Home - About - Disclaimer - Privacy