Results 41 to 50 of about 1,248,941 (203)
Structural and dynamical properties of central nervous system proteins with pharmaceutical and biotechnological potential. [PDF]
, 2010 Neurodegenerative diseases are widespread pathologies of large social impact that include: prion, Alzheimer and Parkinson disease, Huntington chorea and amyotrophic lateral sclerosis.
Stanzione, Francesca
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Brain, Behavior, & Immunity - HealthThe nerve growth factor receptor, also referred to as tumour necrosis factor II and the p75 neurotrophin receptor (p75), serves pleiotropic functions in both the peripheral and central nervous system, involving modulation of immune responses, cell ...
Jessica Chandra
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Etiological Roles of p75NTR in a Mouse Model of Wet Age-Related Macular Degeneration
Cells, 2023 Choroidal neovascularization (CNV) is a pathological angiogenesis of the choroidal plexus of the retina and is a key feature in the wet form of age-related macular degeneration.
Paula Virginia Subirada +7 more
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PLoS ONE, 2011 BackgroundNeurotrophin receptors were initially identified in neural cells. They were recently detected in some cancers in association with invasiveness, but the function of these tyrosine kinase receptors was not previously investigated in colorectal ...
Hussein Akil +4 more
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p75 neurotrophin receptor and fenretinide-induced signaling in neuroblastoma [PDF]
Cancer Chemotherapy and Pharmacology, 2013 Neuroblastoma is the most common extracranial solid tumor of childhood. The retinoic acid analogue, fenretinide (4-hydroxyphenyl retinamide; 4-HPR), induces apoptosis in neuroblastoma cells in vitro and is currently in clinical trials for children with refractory neuroblastoma.
Veena R, Ganeshan, Nina F, Schor
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Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis [PDF]
, 2012 Neurotrophins comprise a group of neuronal growth factors that are essential for the development and maintenance of the nervous system. However, the immature pro-neurotrophins promote apoptosis by engaging in a complex with sortilin and the p75 ...
Autio, Henri +10 more
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Sortilin participates in light-dependent photoreceptor degeneration in vivo.
PLoS ONE, 2012 Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination.
Ana M Santos +5 more
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Cell Reports, 2017 Producing the neuronal diversity required to adequately discriminate all elements of somatosensation is a complex task during organogenesis. The mechanisms guiding this process during dorsal root ganglion (DRG) sensory neuron specification remain poorly ...
Zhijiang Chen +8 more
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Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
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Control of the cell cycle by neurotrophins: lessons from the p75 neurotrophin receptor.
Histology and histopathology, 2002 Peer ...
López-Sánchez, N., Frade, J.M.
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