Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action. [PDF]
PLoS Biology, 2014 The p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily, is required as a co-receptor for the Nogo receptor (NgR) to mediate the activity of myelin-associated inhibitors such as Nogo, MAG, and OMgp.
Marçal Vilar +7 more
doaj +1 more source
Expression of the p75 neurotrophin receptor in acute leukaemia [PDF]
British Journal of Haematology, 2005 SummaryThe dLNGFR is a cytoplasmically deleted form of the low‐affinity nerve growth factor receptor (LNGFR, also known as p75NTR). Recently, we observed a myeloid leukaemia in mice transplanted with dLNGFR‐modified bone marrow cells. Retroviral‐mediated expression of dLNGFR was suspected to contribute to the murine leukaemia.
Gernot, Beutel +13 more
openaire +2 more sources
Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth. [PDF]
PLoS ONE, 2013 BACKGROUND: The cleavage of β-amyloid precursor protein (APP) generates multiple proteins: Soluble β-amyloid Precursor Protein Alpha (sAPPα), sAPPβ, and amyloid β (Aβ).
Noriko Hasebe +5 more
doaj +1 more source
Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis
Biomolecules, 2021 Wnt/β-catenin signaling controls many biological processes for the generation and sustainability of proper tissue size, organization and function during development and homeostasis.
Ozgun Ozalp +8 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2017 Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. The accumulation of Aβ in the brain is thought to play a causative role in the development of cognitive dysfunction in Alzheimer's disease.
Li An +9 more
doaj +1 more source
Mouse embryonic stem cells as a discovery tool in neurobiology [PDF]
, 2012 Mouse ES cells can recapitulate, under suitable tissue culture conditions, early events in neurogenesis. As wildtype or genetically modified ES cells can be grown in unlimited quantities, their differentiation into neurons represents an attractive model
Nikoletopoulou, Vassiliki
core +1 more source
Immunohistochemical Detection of p75 Neurotrophin Receptor (p75-NTR) in Follicular and Plexiform Ameloblastoma [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Ameloblastoma holds a unique position among benign tumours by its locally destructive and invasive nature. Recently improvised molecular techniques helped researchers to unravel the myth behind such biologic behaviour.
YOITHAPPRABHUNATH THUKANAYAKANPALAYAM RAGUNATHAN +3 more
doaj +1 more source
Retrograde apoptotic signaling by the p75 neurotrophin receptor. [PDF]
Neuronal Signal, 2017 Neurotrophins are target-derived factors necessary for mammalian nervous system development and maintenance. They are typically produced by neuronal target tissues and interact with their receptors at axonal endings. Therefore, locally generated neurotrophin signals must be conveyed from the axon back to the cell soma.
Pathak A, Carter BD.
europepmc +4 more sources
Mice lacking protease nexin-1 show delayed structural and functional recovery after sciatic nerve crush [PDF]
, 2007 Multiple molecular mechanisms influence nerve regeneration. Because serine proteases were shown to affect peripheral nerve regeneration, we performed nerve crush experiments to study synapse reinnervation in adult mice lacking the serpin protease nexin-1
Atanasoski, Suzana +7 more
core +1 more source
Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains [PDF]
, 2009 Several lines of evidence implicate BDNF in the pathophysiology of psychiatric illness. BDNF polymorphisms have also been associated with the risk of schizophrenia and mood disorders.
Dunham, Jason S. +12 more
core +1 more source