Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells. [PDF]
Cell Death Dis, 2019 Lipid-induced toxicity is part of several human diseases, but the mechanisms involved are not fully understood. Fatty liver is characterized by the expression of different growth and tissue factors. The neurotrophin, nerve growth factor (NGF) and its pro-
Pham DD +10 more
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p75 neurotrophin receptor regulates craniofacial growth and morphology in postnatal development [PDF]
Frontiers in Cell and Developmental BiologyCraniofacial abnormalities are among the most prevalent congenital defects, significantly affecting appearance, function, and quality of life. While the role of genetic mutations in craniofacial malformations is recognized, the underlying molecular ...
Byron Zhao +13 more
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Journal of Biological Chemistry, 2017 The function of protein products generated from intramembraneous cleavage by the γ-secretase complex is not well defined. The γ-secretase complex is responsible for the cleavage of several transmembrane proteins, most notably the amyloid precursor ...
Khalil Saadipour +2 more
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p75 neurotrophin receptor shapes the dynamics of adult hippocampal neurogenesis in Alzheimer’s disease [PDF]
Alzheimer’s Research & TherapyBackground Alzheimer’s Disease (AD) is a neurodegenerative disorder primarily characterized by memory loss and cognitive decline. The AD-driven impairment of adult hippocampal neurogenesis - the process of generating new neurons in the dentate gyrus - is
Maria Anna Papadopoulou +6 more
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Structural basis of death domain signaling in the p75 neurotrophin receptor
eLife, 2015 Death domains (DDs) mediate assembly of oligomeric complexes for activation of downstream signaling pathways through incompletely understood mechanisms.
Zhi Lin +6 more
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The extracellular domain of neurotrophin receptor p75 as a candidate biomarker for amyotrophic lateral sclerosis. [PDF]
PLoS ONE, 2014 Objective biomarkers for amyotrophic lateral sclerosis would facilitate the discovery of new treatments. The common neurotrophin receptor p75 is up regulated and the extracellular domain cleaved from injured neurons and peripheral glia in amyotrophic ...
Stephanie R Shepheard +4 more
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Modulation of p75 neurotrophin receptor mitigates brain damage following ischemic stroke in mice [PDF]
Neural Regeneration ResearchGolnoush Mirzahosseini, Tauheed Ishrat
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Gamma-secretase represents a therapeutic target for the treatment of invasive glioma mediated by the p75 neurotrophin receptor. [PDF]
PLoS Biology, 2008 The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis (RIP)
LiMei Wang +8 more
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Heterodimerization of p45-p75 modulates p75 signaling: structural basis and mechanism of action. [PDF]
PLoS Biology, 2014 The p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily, is required as a co-receptor for the Nogo receptor (NgR) to mediate the activity of myelin-associated inhibitors such as Nogo, MAG, and OMgp.
Marçal Vilar +7 more
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Association of the p75 Neurotrophin Receptor with TRAF6 [PDF]
Journal of Biological Chemistry, 1999 In addition to the Trk tyrosine kinase receptors, neurotrophins also bind to a second receptor, p75, a member of the tumor necrosis factor receptor superfamily. Several signaling pathways have been implicated for p75 in the absence of Trk receptors, including induction of NF-kappaB and c-Jun kinase activities and increased production of ceramide ...
G, Khursigara, J R, Orlinick, M V, Chao
openaire +2 more sources