Results 71 to 80 of about 1,248,941 (203)

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, Volume 293, Issue 16, Page 4789-4804, August 2026.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Sodium Butyrate Attenuates Sevoflurane‐Induced Impaired Myelination and Neurobehavioral Deficits in Neonatal Mice via the H3K9ac/BDNF/TrkB Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
Repeated exposure to sevoflurane in neonatal mice leads to impaired myelin development and neurobehavioral dysfunction, a process closely associated with reduced butyrate levels in vivo. Sodium butyrate supplementation effectively ameliorates these sevoflurane‐induced abnormalities by downregulating HDAC3 and HDAC8 expression, enhancing H3K9ac levels ...
Chang Liu, Xinyao Bai, Xinyue Liu, Jinjie Li, Ruizhu Liu, Jinlan Jiang, Guoqing Zhao   +6 more
wiley   +1 more source

Interaction between the p75 neurotrophin receptor and a novel adaptor protein [PDF]

, 2008
The neurotrophin plays an important role in the development, differentiation and survival of the nervous system in vertebrates. It exerts its cellular effects through two different receptors, the Trk receptor tyrosine kinase neurotrophin receptor and
Lee, Yun-Hee, Cho, Jung-Sun, Lee, Seung-Pyo, Yu, Ji-Hee, Paik, Ki-Suk, Park, Han-Jeong, Chang, Mi-Sook   +6 more
core  

Expression and purification of the p75 neurotrophin receptor transmembrane domain using a ketosteroid isomerase tag

Microbial Cell Factories, 2012
Background Receptors with a single transmembrane (TM) domain are essential for the signal transduction across the cell membrane. NMR spectroscopy is a powerful tool to study structure of the single TM domain.
Li Qingxin, Chen Angela, Gayen Shovanlal, Kang CongBao   +3 more
doaj   +1 more source

Meeting report for the Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026)

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract The Second International Conference on Unconventional Animal Models of Alzheimer's Disease and Aging (UAMAA 2026) was held February 9 through 11, 2026, in Irvine, California. Building upon the inaugural meeting in Santiago, Chile (2023), this conference expanded an international effort to develop, characterize, and rigorously evaluate non ...
Jane Alshami, Ginny Wu, B. Maximiliano Garduño, Afonso C. Silva, Stacey J. Sukoff Rizzo, Patricia Cogram, Xiangmin Xu   +6 more
wiley   +1 more source

The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis

BMC Neuroscience, 2010
Background The ability to regulate neurogenesis in the adult dentate gyrus will require further identification and characterization of the receptors regulating this process.
Bernabeu Ramon O, Longo Frank M
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

Expression of the low affinity neurotrophin receptor p75 in spinal motoneurons in a transgenic mouse model for amyotrophic lateral sclerosis

, 2003
Amyotrophic lateral sclerosis is a lethal neurodegenerative disorder involving motoneuron loss in the cortex, brainstem and spinal cord, resulting in progressive paralysis.
Kust, B M, Bruggeman, RWG, Copray, J C V M, Copray, JCVM, Bruggeman, R W G, Kst, BM, Kust, BM, Brouwer, N, Mantingh, I, Boddeke, H W G M, Jaarsma, D, Mantingh, [No Value], Boddeke, HWGM, Jaarsma, Dick   +13 more
core   +1 more source

Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells

Frontiers in Immunology, 2017
Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the
Joanna Bandoła, Cornelia Richter, Martin Ryser, Arshad Jamal, Arshad Jamal, Michelle P. Ashton, Malte von Bonin, Malte von Bonin, Malte von Bonin, Matthias Kuhn, Benjamin Dorschner, Dimitra Alexopoulou, Katrin Navratiel, Ingo Roeder, Andreas Dahl, Christian M. Hedrich, Ezio Bonifacio, Sebastian Brenner, Sebastian Brenner, Sebastian Thieme   +19 more
doaj   +1 more source

Simultaneous Electrochemical Detection of NGF and proNGF Under Native Conditions Using Molecularly Imprinted Polymers: Toward Point‐of‐Care Diagnosis of Alzheimer's Disease

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
This study relies on the development of a new sensor that can detect two closely related proteins involved in Alzheimer's disease at the same time. Unlike traditional methods, it works in natural conditions and does not require sample pretreatment. The device is highly sensitive and was successfully tested on patient samples, offering promises for ...
Giulia Siciliano, Alfredo De Cillis, Elena Clabassi, Francesco Ferrara, Maria Serena Chiriacò, Antonio Turco, Clarissa Loiola, Chiara Zecca, Maria Teresa Dell'Abate, Giancarlo Logroscino, Giuseppe Gigli, Francesca Malerba, Elisabetta Primiceri   +12 more
wiley   +1 more source