Results 91 to 100 of about 25,950 (247)
Region-specific integration of embryonic stem cell-derived neuronal precursors into a pre-existing neuronal circuit. [PDF]
PLoS ONE, 2013 Enduring reorganization is accepted as a fundamental process of adult neural plasticity. The most dramatic example of this reorganization is the birth and continuously occurring incorporation of new neurons into the pre-existing network of the adult ...
Franziska Neuser +4 more
doaj +1 more source
Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts : implications for neuromodulation [PDF]
, 2010 Copyright © 2010 the authorsBrain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been hown to be necessary for the activation of specific signaling ...
Assaife-Lopes, Natália +5 more
core +1 more source
p75NTR Promotes Circadian‐Driven Mineralization During Tooth Development via CK2/PER2 Pathway
Cell Proliferation, Volume 59, Issue 5, May 2026.The diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Manzhu Zhao +8 more
wiley +1 more source
Neurotrophin receptors expression and JNK pathway activation in human astrocytomas
BMC Cancer, 2007 Background Neurotrophins are growth factors that regulate cell growth, differentiation and apoptosis in the nervous system. Their diverse actions are mediated through two different transmembrane – receptor signaling systems: Trk receptor tyrosine kinases
Maraziotis Theodore +4 more
doaj +1 more source
p75 neurotrophin receptor and fenretinide-induced signaling in neuroblastoma [PDF]
Cancer Chemotherapy and Pharmacology, 2013 Neuroblastoma is the most common extracranial solid tumor of childhood. The retinoic acid analogue, fenretinide (4-hydroxyphenyl retinamide; 4-HPR), induces apoptosis in neuroblastoma cells in vitro and is currently in clinical trials for children with refractory neuroblastoma.
Veena R, Ganeshan, Nina F, Schor
openaire +2 more sources
Rational Design of Nanobodies Targeting LINGO‐1
Applied Research, Volume 5, Issue 2, April 2026.We rationally designed and recombinantly produced a panel of single‐domain antibodies (nanobodies) targeting the human transmembrane protein LINGO‐1, a key player in multiple sclerosis. ABSTRACT The leucine‐rich repeat and immunoglobulin‐like domain‐containing Nogo receptor‐interacting protein 1 (LINGO‐1) is a transmembrane protein expressed in neurons
Alexander Röntgen +6 more
wiley +1 more source
Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons [PDF]
, 2010 Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation of different forms of synaptic plasticity.
Davis López de Carrizosa, María América +4 more
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.The OEC induction system significantly enhanced SSC differentiation into spinal neurons, with optimal LPS concentration improving outcomes. Induced cells exhibited neuronal traits, relying on the JAK2/STAT3 pathway, whose suppression aided differentiation and repair.
Xinyu Guo +3 more
wiley +1 more source
p75 Neurotrophin Receptor Suppresses the Proliferation of Human Gastric Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2007 Identifying an effective therapeutic target is pivotal in the treatment of gastric cancer. In this study, we investigated the expression of p75 neurotrophin receptor (p75NTR) in gastric cancer and the impact of its alteration on tumor growth.
Haifeng Jin +10 more
doaj +1 more source
Journal of Neuroscience, 2016 The p75 neurotrophin receptor (p75NTR) mediates neuronal death in response to neural insults by activating a caspase apoptotic pathway. The oligomeric state and activation mechanism that enable p75NTR to mediate these effects have recently been called ...
Kazuhiro Tanaka +4 more
semanticscholar +1 more source