Results 101 to 110 of about 25,950 (247)
Nuclear Translocation of the p75 Neurotrophin Receptor Cytoplasmic Domain in Response to Neurotrophin Binding [PDF]
The Journal of Neuroscience, 2005 The intracellular domain of the p75 neurotrophin receptor (p75ICD) can be released by γ-secretase in response to the previous activation of α-secretase by phorbol esters. However, ligand-dependent release of p75ICDhas yet to be described. We show here that nerve growth factor can induce the release of p75ICDand facilitate its translocation to the ...
openaire +3 more sources
Nuclear Localization of the p75 Neurotrophin Receptor Intracellular Domain [PDF]
Journal of Biological Chemistry, 2010 The p75 neurotrophin receptor, a member of the tumor necrosis factor superfamily of receptors, undergoes an alpha-secretase-mediated release of its extracellular domain, followed by a gamma-secretase-mediated intramembrane cleavage. Like amyloid precursor protein and Notch, gamma-secretase cleavage of the p75 receptor releases an intracellular domain ...
Christopher N, Parkhurst +2 more
openaire +2 more sources
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.ABSTRACT Adeno‐associated virus (AAV) gene therapies have achieved some clinical success, with multiple products reaching regulatory approval. Encapsulation of AAV vectors within engineered extracellular vesicles (EVs) is an emerging strategy which could help overcome challenges including pre‐existing anti‐capsid immunity and the need for controlling ...
Jonathan D. Boucher +5 more
wiley +1 more source
p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells [PDF]
, 2007 Although our understanding of adult neurogenesis has increased dramatically over the last decade, confusion still exists regarding both the identity of the stem cell responsible for neuron production and the mechanisms that regulate its activity. Here we
Bartlett, P. F. +4 more
core +1 more source
eLife, 2016 Cerebellar granule cell progenitors (GCP) proliferate extensively in the external granule layer (EGL) of the developing cerebellum prior to differentiating and migrating.
Juan P. Zanin +2 more
semanticscholar +1 more source
Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy
MedComm, Volume 7, Issue 4, April 2026.In this review, we summarize nerve–cancer interactions and conclude two additional interactions, “perineural invasion” and “neuro‐microbic‐oncology.” Emphasizing the important role of nerves in tumor progression. The nervous system also contributes to the development of cancer comorbidities such as cancer depression and cognitive dysfunction.
Ting Wang +5 more
wiley +1 more source
Microbial Cell Factories, 2012 Background Receptors with a single transmembrane (TM) domain are essential for the signal transduction across the cell membrane. NMR spectroscopy is a powerful tool to study structure of the single TM domain.
Li Qingxin +3 more
doaj +1 more source
The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing [PDF]
, 2018 AIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues.
Abban, G. +6 more
core +1 more source
Advanced Healthcare Materials, Volume 15, Issue 9, 6 March 2026.Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar +9 more
wiley +1 more source
BMC Neuroscience, 2010 Background The ability to regulate neurogenesis in the adult dentate gyrus will require further identification and characterization of the receptors regulating this process.
Bernabeu Ramon O, Longo Frank M
doaj +1 more source