Results 111 to 120 of about 14,094 (223)

Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons [PDF]

, 2010
Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation of different forms of synaptic plasticity.
Davis López de Carrizosa, María América, Morado Díaz, Camilo José, Morcuende Fernández, Sara R., Pastor Loro, Ángel Manuel, Rodríguez de la Cruz, Rosa María   +4 more
core   +1 more source

From Neural Crest Development to Cancer and Vice Versa: How p75NTR and (Pro)neurotrophins Could Act on Cell Migration and Invasion?

Frontiers in Molecular Neuroscience, 2018
The p75 neurotrophin receptor (p75NTR), also known as low-affinity nerve growth factor, belongs to the tumor necrosis factor family of receptors. p75NTR is widely expressed in the nervous system during the development, as well as, in the neural crest ...
Sabine Wislet, Geoffrey Vandervelden, Bernard Rogister, Bernard Rogister   +3 more
doaj   +1 more source

Differentiation of Human Embryonic Stem Cells into Cells with Corneal Keratocyte Phenotype [PDF]

, 2013
Corneal transparency depends on a unique extracellular matrix secreted by stromal keratocytes, mesenchymal cells of neural crest lineage. Derivation of keratocytes from human embryonic stem (hES) cells could elucidate the keratocyte developmental pathway
Chan, AA, Davoli, KA, Du, Y, Funderburgh, JL, Funderburgh, ML, Hertsenberg, AJ, Mann, MM, Mich-Basso, JD, Yang, L   +8 more
core   +2 more sources

Identification of Prdm genes in human corneal endothelium [PDF]

, 2017
Corneal endothelial cells (CECs) are essential for maintaining corneal stromal hydration and ensuring its transparency, which is necessary for normal vision. Dysfunction of CECs leads to stromal decompensation, loss of transparency and corneal blindness.
Aldahmesh, Alexandra Chittka, Arndt, Bikoff, Burkitt Wright, Chi, Chittka, Chittka, Chittka, Christiana Georgiou, Derunes, Di Zazzo, Dominic G. O'Donovan, Eghrari, Eppert, Fog, Günesdogan, Hara Susumu, Harper, Hohenauer, Juneja, Jung, Kajimura, Komai, Kostadin Rolev, Liu, Madhavan S. Rajan, Micheal, Micheal, Ohinata, Parekh, Porter, Porter, Qi, Savitsky, Seale, Siegel, Tan, Wu, Zannino, Zhang, Zhang   +41 more
core   +2 more sources

Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor

The Journal of Clinical Investigation, 2022
Cell surface receptors, ligands, and adhesion molecules underlie development, circuit formation, and synaptic function of the central nervous system and represent important therapeutic targets for many neuropathologies.
Nicholas C. Morano, Roshelle S. Smith, Victor Danelon, Ryan Schreiner, Uttsav Patel, Natalia G. Herrera, Carla Smith, Steven M. Olson, Michelle K. Laerke, Alev Celikgil, Scott J. Garforth, Sarah C. Garrett-Thomson, Francis S. Lee, Barbara L. Hempstead, Steven C. Almo   +14 more
doaj   +1 more source

Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function [PDF]

, 2017
ACKGROUND & AIMS: Hirschsprung disease is caused by failure of enteric neural crest cells (ENCCs) to fully colonize the bowel, leading to bowel obstruction and megacolon. Heterozygous mutations in the coding region of the RET gene cause a severe form of
Garcia-Barcelo, MM, Gui, H, Lai, FPL, Lai, KWH, Lau, CST, Ngan, ESW, Tam, PKH, Tse, HF, Wang, X, Wong, JKL, Zhou, T   +10 more
core   +1 more source

The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons

Frontiers in Cellular Neuroscience, 2019
Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75NTR), which increased the affinity and ...
Juan P. Zanin, Laura E. Montroull, Marta Volosin, Wilma J. Friedman   +3 more
doaj   +1 more source

Expression of nuclear survivin in normal skin and squamous cell carcinoma: a possible role in tumor invasion [PDF]

, 2013
Background: Survivin is detected in few adult normal cells and it is highly expressed in cancer. Nuclear survivin facilitates cell cycle entry, while the mitochondrial pool protects cells from apoptosis.
Dallaglio, Katiuscia, Lotti, Roberta, M., Puviani, Maiorana, Antonino, Marconi, Alessandra, Morandi, Paolo, Petrachi, Tiziana, Pincelli, Carlo, Saltari, Annalisa, Truzzi, Francesca   +9 more
core   +2 more sources

Silencing p75NTR regulates osteogenic differentiation and angiogenesis of BMSCs to enhance bone healing in fractured rats

Journal of Orthopaedic Surgery and Research
Background Fractures heal through a process that involves angiogenesis and osteogenesis but may also lead to non-union or delayed healing. Bone marrow mesenchymal stem cells (BMSCs) have been reported to play a pivotal role in bone formation and vascular
Zhifeng Wu, Yongming Yang, Ming Wang
doaj   +1 more source

Suppression of neurite outgrowth by high-dose nerve growth factor is independent of functional p75NTR receptors

Neurobiology of Disease, 2004
We have previously demonstrated that high concentrations of nerve growth factor suppress neurite outgrowth from sensory neurons. Inhibition could be mediated by either the p75NTR or TrkA receptor.
Anna M. Conti, Stephen Brimijoin, Laurence J. Miller, Anthony J. Windebank   +3 more
doaj   +1 more source