Results 121 to 130 of about 14,094 (223)

An antisense-long-noncoding-RNA modulates p75NTR expression levels during neuronal polarization

iScience
Summary: Proper polarization of newly generated neurons is a critical process for neural network formation and brain development. The pan-neurotrophin p75NTR receptor plays a key role in this process localizing asymmetrically in one of the ...
Veronica De Paolis, Nicoletta Paolillo, Tiziano Siri, Alessandra Grosso, Veronica Lorello, Cristina Spina, Gabriele Caporali, Federico La Regina, Beatrice Vignoli, Corinna Giorgi   +9 more
doaj   +1 more source

Deletion of p75NTR prevents vaso-obliteration and retinal neovascularization via activation of Trk- A receptor in ischemic retinopathy model

Scientific Reports, 2018
Ischemic retinopathy is characterized by ischemia followed by retinal neovascularization (RNV) resulting in visual impairment. Given the role of neuron-secreted growth factors in regulating angiogenesis, we examined how genetic deletion of the ...
Sally L. Elshaer, Azza B. El-Remessy
doaj   +1 more source

The glia response after peripheral nerve injury: A comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies [PDF]

, 2017
The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). One reason for this difference is the difference in glial cell types between the two systems.
Barton, Matthew J., Clarke, Mary, Ekberg, Jenny, St. John, James, Wright, Alison   +4 more
core   +2 more sources

Palmitoylation of death receptor p75NTR contributes to Alzheimer’s disease progression by regulating APP trafficking and degradation

Alzheimer’s Research & Therapy
Although protein palmitoylation has been associated with Alzheimer’s Disease (AD), it remains unclear whether or how palmitoylation of specific proteins contributes to any of the pathological features of AD.
Yanchen Ma, Meng Xie, Carlos F. Ibáñez
doaj   +1 more source

Expression and clinical significance of p75NTR in esophageal squamous cell carcinoma

Mathematical Biosciences and Engineering, 2019
Objectives: To analyze the expression and clinical significance of p75NTR in esophageal squamous cell carcinoma. Methods: Sixty patients with esophageal squamous cell carcinoma who underwent surgical resection in our hospital between January 2017 and January 2018 were selected as the study subjects.
Dijian Shen, Youhua Jiang, Kaiyi Tao
openaire   +3 more sources

p75NTR is involved in inflammatory responses in psoriasis

, 2023
Background. Psoriasis is a cutaneous chronic inflammatory disease, characterized by excessive proliferation and abnormal differentiation of keratinocytes and infiltration of multiple inflammatory cells. Moreover, different neuropeptides have been involved in the pathogenesis of psoriasis. NGF is known to increase in psoriasis and to cause neuropeptides
Alessandra Magenta, Sara Sileno, Marco D'Agostino, Luciapia Farina, Luigi Manni, Marzia Soligo, Albanesi C, Melillo G, Luisa Bracci Laudiero   +8 more
openaire   +1 more source

Spatio-temporal control of neurotrophin trafficking and signalling in primary neurons cultured inside microfluidic chambers

, 2011
My PhD project was aimed at applying microfluidics technology to the study of longrange neurotrophin signalling. Neurotrophins are target-derived growth and survival factors that, among other functions, prevent innervating neurons from undergoing ...
Menendez, Guillermo, Menendez, Guillermo
core   +1 more source

p75NTR antibody-conjugated microspheres: an approach to guided tissue regeneration by selective recruitment of endogenous periodontal ligament cells

Frontiers in Bioengineering and Biotechnology
Repairing defects in alveolar bone is essential for regenerating periodontal tissue, but it is a formidable challenge. One promising therapeutic approach involves using a strategy that specifically recruits periodontal ligament cells (PDLCs) with high ...
Xuqiang Zou, Bo Xie, Xuelian Peng, Mingjie Lu, Dan Xu, Hongyan Yuan, Yixin Zhang, Di Wang, Manzhu Zhao, Rui Liu, Xiujie Wen   +10 more
doaj   +1 more source

Structure of the C-terminal domain of TRADD reveals a novel fold in the death domain superfamily

Scientific Reports, 2017
The TNFR1-associated death domain protein (TRADD) is an intracellular adaptor protein involved in various signaling pathways, such as antiapoptosis. Its C-terminal death domain (DD) is responsible for binding other DD-containing proteins including the ...
Ning Zhang, Wensu Yuan, Jing-Song Fan, Zhi Lin   +3 more
doaj   +1 more source

The P53 and P75ntr Expression Status in Medulloblastomas: An Insight

Introduction: Medulloblastomas (MBs) are primitive neuroectodermal tumors (PNETs) located in the cerebellum. They are the most common malignant brain tumors in children, but their origin remains a mystery. MB cells express various neuronal and glial markers, suggesting they arise from different stages of neural development.
Kamlesh Yadav, Pawan Kumar Vishwakarma, Amit Kumar, Krushna Chandra Pani   +3 more
openaire   +1 more source