Results 81 to 90 of about 9,698 (210)
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, Volume 293, Issue 16, Page 4789-4804, August 2026.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective
Advanced Science, Volume 13, Issue 41, 22 July 2026.This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin +4 more
wiley +1 more source
BMC Oral HealthBackground The aim to this study was to explore the effect of p75NTR on the mineralization and development of maxillofacial processes. Moreover, we tried to elaborate the potential mechanism of p75NTR’s effect on the odontogenic or osteogenic ...
Feng Li +5 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract Alzheimer's disease (AD) is a neurodegenerative condition marked by cognitive decline and synaptic issues. Recent studies show primary cilia (PCs), sensory organelles present on the surface of most mammalian cells, act as a critical regulators of brain homeostasis and signaling.
Vishal Singh Guleria +1 more
wiley +1 more source
Pharmacologically diverse antidepressants were recently described to bind to TrkB and drive a positive allosteric modulation of endogenous BDNF. Although neurotrophins such as BDNF can bind to the p75 neurotrophin receptor (p75NTR), their precursors are ...
Cassiano Diniz (5650805)
core +1 more source
Hippocampal membrane-associated p75NTR levels are increased in Alzheimer’s disease
, 2012 The pan-specific p75 neurotrophin receptor (p75NTR) is believed to play an important role in the pathogenesis of Alzheimer’s disease. It is involved in mediating amyloid-ß (Aβ) toxicity and stimulating amyloidogenesis.
Ito S. +6 more
core +1 more source
Pharmacologically diverse antidepressants were recently described to bind to TrkB and drive a positive allosteric modulation of endogenous BDNF. Although neurotrophins such as BDNF can bind to the p75 neurotrophin receptor (p75NTR), their precursors are ...
Cassiano Diniz (5650805)
core +1 more source
Site-specific biotinylation of TrkA and P75NTR receptors.
, 2014 Western blot for the analysis of the biotinylation reaction in living cells of A1/S6-TrkA-EGFP (A) and A1/S6-P75NTR-EGFP constructs (B) using CoA-biotin substrate and AcpS or SfpS PPTases.
Teresa De Nadai (666478) +8 more
core +1 more source
Characterization of NGF, trkANGFR, and p75NTR in Retina of Mice Lacking Reelin Glycoprotein
International Journal of Cell Biology, 2014 Both Reelin and Nerve Growth Factor (NGF) exert crucial roles in retinal development. Retinogenesis is severely impaired in E-reeler mice, a model of Reelin deficiency showing specific Green Fluorescent Protein expression in Rod Bipolar Cells (RBCs ...
Bijorn Omar Balzamino +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 The p75 neurotrophin receptor (p75NTR), also known as low-affinity nerve growth factor, belongs to the tumor necrosis factor family of receptors. p75NTR is widely expressed in the nervous system during the development, as well as, in the neural crest ...
Sabine Wislet +3 more
doaj +1 more source