Results 81 to 90 of about 14,094 (223)

The expression system affects the binding affinity between p75NTR and proNGF

Biochemistry and Biophysics Reports
ProNGF (nerve growth factor) is a precursor of NGF and a signaling peptide exerting opposite effects on neuronal cells, i.e., apoptotic or neuritogenic.
Mami Hino, Masayuki Nakanishi, Hiroshi Nomoto   +2 more
doaj   +1 more source

Neural crest stem cells and their potential therapeutic applications [PDF]

, 2016
The neural crest (NC) is a remarkable transient structure generated during early vertebrate development. The neural crest progenitors have extensive migratory capacity and multipotency, harboring stem cell-like characteristics such as self-renewal.
Cheung, MCH, Liu, AJ
core   +1 more source

Identification and Functional Characterization of Novel and Recurrent NTRK1 Variants in Chinese Families With Congenital Insensitivity to Pain With Anhidrosis: A Combined Clinical, Genetic, and Functional Study

European Journal of Neurology, Volume 33, Issue 5, May 2026.
This study investigates four Chinese families with congenital insensitivity to pain with anhidrosis (CIPA). Through next‐generation sequencing, we identified seven NTRK1 variants, including two novel mutations. Functional characterization of five identified missense and indel variants revealed distinct disruptions in the NGF‐TrkA pathway, ranging from ...
Yaqiong Ren, Yue Cao, Fangfang Cheng, Jin Dai, Yuan Zhang, Xinxin Wang, Jiali Chen, Lijun Zhou, Xiaoxiang Song, Hongying Wang   +9 more
wiley   +1 more source

The p75NTR extracellular domain [PDF]

Prion, 2011
Senile plaques composed of amyloid-beta (Aβ) in the brain are one of the hallmarks of Alzheimer disease (AD). Removal of Aβ from the brain is the most important therapeutic strategy for AD. The solubility of Aβ is critical for its endocytosis, transcytosis and removal from the brain.
Zhou, Xin-Fu, Wang, Yan-Jiang
openaire   +4 more sources

Silencing p75NTR prevents proNGF-induced endothelial cell death and development of acellular capillaries in rat retina

Molecular Therapy: Methods & Clinical Development, 2015
Accumulation of the nerve growth factor precursor (proNGF) and its receptor p75NTR have been associated with several neurodegenerative diseases in both brain and retina. However, whether proNGF contributes to microvascular degeneration remain unexplored.
Ahmed Y Shanab, Barbara A Mysona, Suraporn Matragoon, Azza B El-Remessy   +3 more
doaj   +1 more source

Ablation of p75NTR signaling strengthens gamma–theta rhythm interaction and counteracts Aβ-induced degradation of neuronal dynamics in mouse hippocampus in vitro

Translational Psychiatry, 2021
Gamma and theta brain rhythms play important roles in cognition and their interaction can affect gamma oscillation features. Hippocampal theta oscillations depend on cholinergic and GABAergic input from the medial septum-diagonal band of Broca.
Yuniesky Andrade-Talavera, Hugo Balleza-Tapia, Pablo Dolz-Gaitón, Gefei Chen, Jan Johansson, André Fisahn   +5 more
doaj   +1 more source

Characterisation of ERK distribution and activity in rat pheochromocytoma cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University [PDF]

, 1998
Nerve growth factor (NGF) binds to the NGF receptor, TrkA, at the tips of nerve cell axons, sending a signal that prevents programmed cell death and causes survival, growth, and differentiation of the nerve cell.
MacCormick, Matthew Edgar
core  

Nerve growth factor/p75 neurotrophin receptor–mediated sensitization of rat sensory neurons depends on membrane cholesterol [PDF]

, 2013
Nerve growth factor (NGF) is an important mediator in the initiation of the inflammatory response and NGF via activation of the p75 neurotrophin receptor (p75(NTR)) and downstream sphingomyelin signaling leads to significant enhancement of the ...
Khanna, R, Nicol, Grant D., Zhang, YH
core   +1 more source

Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease

Advanced Science, Volume 13, Issue 20, 9 April 2026.
This research identified cardiac amyloid pathology, neurotrophic factor depletion, and reduced myocardial nerve function in a transgenic model of cerebral amyloidosis (Tg2576), Aβ‐challenged cardiomyocytes, and in human AD heart tissue. These findings carry significant diagnostic and therapeutic implications, emphasizing the role of neuro‐signaling ...
Andrea Elia, Rebecca Parodi‐Rullan, Rafael Vazquez‐Torres, Ashley Carey, Huaqing Zhao, Sabzali Javadov, Silvia Fossati   +6 more
wiley   +1 more source

Organotypic culture of normal, dysplastic and squamous cell carcinoma-derived oral cell lines reveals loss of spatial regulation of CD44 and p75NTR in malignancy [PDF]

, 2012
Oral squamous cell carcinomas (OSCC) often arise from dysplastic lesions. The role of cancer stem cells in tumour initiation is widely accepted, yet the potential existence of pre-cancerous stem cells in dysplastic tissue has received little attention ...
Ademuyiwa, Al-Hajj, Alison, Benayoun, Berndt, Chakrabarty, Chan, Chang, Chen, Chen, Chen, Clay, Dawson, Dickson, Dudas, Gao, Goessel, Huang, Lim, Mack, Myatt, Nakamura, Okamoto, Okumura, Pries, Prince, Ralston, Rheinwald, Rogers, Rosen, Shackleton, Smeets, Tang, Thomson, Vandervelden, Vanhecke, Visvader, Zhang   +37 more
core   +3 more sources