Results 21 to 30 of about 9,698 (210)
Differences in the surface binding and endocytosis of neurotrophins by p75NTR
Molecular and Cellular Neuroscience, 2004 Neurotrophins transmit signals retrogradely from synapses to cell bodies by two different types of surface receptors, p75NTR and Trks. Compared to TrkA, the function of p75NTR in nerve growth factor (NGF) endocytosis is less clear, and it is unknown whether p75NTR by itself may internalize other neurotrophins besides NGF.
Saxena S +5 more
openaire +4 more sources
Signaling of neuronal cell death by the p75NTR neurotrophin receptor
Molecular Neurobiology, 1999 The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes with trkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently of trkA.
Coulson, E. J. +2 more
openaire +6 more sources
p75NTR signal transduction suppressed by BFAR and p75NTR interactions [PDF]
Science China Life Sciences, 2012 p75NTR is a low-affinity nerve growth factor receptor, which promotes cell proliferation as a positive modulator of high-affinity receptor TrkA, as well as binds with cell ligands to induce apoptosis and mediate death signals. To analyze the regulatory mechanisms of p75NTR, the present study utilized a new membrane yeast two-hybrid system to screen a ...
Li, HongMei, Shi, HuiLi, Huo, KeKe
openaire +2 more sources
The role and potential mechanism of p75NTR in mineralization via in vivo p75NTR knockout mice and in vitro ectomesenchymal stem cells [PDF]
Cell Proliferation, 2020 AbstractObjectiveThe aim of this study is to investigate the role and potential mechanism of p75NTR in mineralization in vivo using p75NTR‐knockout mice and in vitro using ectomesenchymal stem cells (EMSCs).Materials and methodsFemur bone mass and daily incisor mineralization speed were assessed in an in vivo p75NTR‐knockout mouse model.
Manzhu Zhao +7 more
openaire +2 more sources
p75NTR: an enhancer of fenretinide toxicity in neuroblastoma [PDF]
Cancer Chemotherapy and Pharmacology, 2013 Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells.
Veena, Ganeshan +2 more
openaire +2 more sources
Frontiers in Cellular Neuroscience, 2019 Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death.
Andrew Speidell +5 more
doaj +1 more source
Isolation and characterization of neural crest-like progenitor cells in human umbilical cord blood
Regenerative Therapy, 2020 Introduction: Neural crest (NC)-like stem/progenitor cells provide an attractive cell source for regenerative medicine because of their multipotent property and ease of isolation from adult tissue.
Zena Al-Bakri +7 more
doaj +1 more source
Journal of Neuroinflammation, 2021 Background Streptococcus pneumoniae meningitis is a destructive central nervous system (CNS) infection with acute and long-term neurological disorders. Previous studies suggest that p75NTR signaling influences cell survival, apoptosis, and proliferation ...
Dandan Zhang +8 more
doaj +1 more source
Genetic Dissection of Neurotrophin Signaling through the p75 Neurotrophin Receptor
Cell Reports, 2012 Structural determinants underlying signaling specificity in the tumor necrosis factor receptor superfamily (TNFRSF) are poorly characterized, and it is unclear whether different signaling outputs can be genetically dissociated.
Ioannis Charalampopoulos +5 more
doaj +1 more source
p75 Neurotrophin Receptor Suppresses the Proliferation of Human Gastric Cancer Cells
Neoplasia: An International Journal for Oncology Research, 2007 Identifying an effective therapeutic target is pivotal in the treatment of gastric cancer. In this study, we investigated the expression of p75 neurotrophin receptor (p75NTR) in gastric cancer and the impact of its alteration on tumor growth.
Haifeng Jin +10 more
doaj +1 more source