p75NTR Promotes Circadian-Driven Mineralization During Tooth Development via CK2/PER2 Pathway. [PDF]
Cell ProlifThe diagram illustrates how the circadian rhythm regulates the p75NTR‐CK2‐PER2 axis, driving rhythmic biomineralisation during tooth development. ABSTRACT Circadian rhythm is an essential biological process that synchronises physiological activities with environmental light/dark cycles.
Zhao M +8 more
europepmc +2 more sources
p75NTR signal transduction suppressed by BFAR and p75NTR interactions [PDF]
Science China Life Sciences, 2012 p75NTR is a low-affinity nerve growth factor receptor, which promotes cell proliferation as a positive modulator of high-affinity receptor TrkA, as well as binds with cell ligands to induce apoptosis and mediate death signals. To analyze the regulatory mechanisms of p75NTR, the present study utilized a new membrane yeast two-hybrid system to screen a ...
Li, HongMei, Shi, HuiLi, Huo, KeKe
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A review of studies on the roles of p75NTR in the tooth development and tissue regeneration [PDF]
Yixue xinzhi zazhi, 2020 p75NTR, a low affinity neurotrophic factor receptor, is considered as a typical neural crest marker. It has been reported that p75NTR not only played an important role in the proliferation, migration, differentiation, survival and apoptosis of neural ...
Shi-Ting LI, Xia YU, Xiu-Jie WEN
doaj +1 more source
The role and potential mechanism of p75NTR in mineralization via in vivo p75NTR knockout mice and in vitro ectomesenchymal stem cells [PDF]
Cell Proliferation, 2020 AbstractObjectiveThe aim of this study is to investigate the role and potential mechanism of p75NTR in mineralization in vivo using p75NTR‐knockout mice and in vitro using ectomesenchymal stem cells (EMSCs).Materials and methodsFemur bone mass and daily incisor mineralization speed were assessed in an in vivo p75NTR‐knockout mouse model.
Manzhu Zhao +7 more
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ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints. A novel pathogenic mechanism in chronic arthritis [PDF]
, 2017 To identify the role of mature nerve growth factor (mNGF), its immature form proNGF and their receptors in arthritis ...
Benedetti, Fabrizio De +9 more
core +1 more source
Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies [PDF]
, 2013 Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain ...
Alberch, J. +5 more
core +1 more source
Regenerative Therapy, 2021 Introduction: The p75 neurotrophin receptor (p75NTR) is known as an efficient marker for the prospective isolation of mesenchymal stem cells (MSCs) and neural crest-derived stem cells (NCSCs). To date, there is quite limited information concerning p75NTR-
Rina Fujii-Tezuka +7 more
doaj +1 more source
Subconjunctival delivery of p75NTR antagonists reduces the inflammatory, vascular, and neurodegenerative pathologies of diabetic retinopathy [PDF]
, 2017 The p75NTR is a novel therapeutic target validated in a streptozotocin mouse model of diabetic retinopathy. Intravitreal (IVT) injection of small molecule p75NTR antagonist THX-B was therapeutic and resolved the inflammatory, vascular, and ...
Barcelona, Pablo Federico +5 more
core +1 more source
p75NTR: an enhancer of fenretinide toxicity in neuroblastoma [PDF]
Cancer Chemotherapy and Pharmacology, 2013 Neuroblastoma is a common, frequently fatal, neural crest tumor of childhood. Chemotherapy-resistant neuroblastoma cells typically have Schwann cell-like ("S-type") morphology and express the p75 neurotrophin receptor (p75NTR). p75NTR has been previously shown to modulate the redox state of neural crest tumor cells.
Veena, Ganeshan +2 more
openaire +2 more sources
Reduced anxiety-like behavior and altered hippocampal morphology in female p75NTR exon IV-/- mice.
Frontiers in Behavioral Neuroscience, 2016 The presence of the neurotrophin receptor p75NTR in adult basal forebrain cholinergic neurons, precursor cells in the subventricular cell layer and the subgranular cell layer of the hippocampus has been linked to alterations in learning as well as ...
Zoe ePuschban +4 more
doaj +1 more source