Results 171 to 180 of about 35,168 (213)
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Physiology of the Neurotrophins
Annual Review of Neuroscience, 1996The neurotrophins are a small group of dimeric proteins that profoundly affect the development of the nervous system of vertebrates. Recent studies have established clear correlations between the survival requirements for different neurotrophins of functionally distinct subsets of sensory neurons.
Lewin, G. R., Barde, Y. A.
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2017
Neurotrophins (NTs) have been implicated in generation and modulation of nociceptive pathways. Change in NTs levels is associated with painful conditions and neurological diseases such as migraine. Currently, it is generally recognized that migraine headaches result from the activation and sensitization of trigeminal sensory afferent fibers leading to ...
L B, Martins +2 more
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Neurotrophins (NTs) have been implicated in generation and modulation of nociceptive pathways. Change in NTs levels is associated with painful conditions and neurological diseases such as migraine. Currently, it is generally recognized that migraine headaches result from the activation and sensitization of trigeminal sensory afferent fibers leading to ...
L B, Martins +2 more
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Neurotrophin signaling through the p75 neurotrophin receptor
Progress in Neurobiology, 2002The neurotrophins are growth factors that play critical roles in the development, maintenance, survival, and death of the nervous system. The signal transducing systems that mediate the diverse biological functions of the neurotrophins are initiated by their interactions with two categories of cell surface receptors, the Trk family of tyrosine kinases ...
Philippe P, Roux, Philip A, Barker
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Trends in Pharmacological Sciences, 1999
Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing neurones in the brains of adult rats. Similar infusions of BDNF into the dorsal raphe nucleus produce an antidepressant effect, as evaluated by several 'learned helplessness'
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Exogenous delivery of the neurotrophic factors, brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3), promotes the function, sprouting and regrowth of 5-HT-containing neurones in the brains of adult rats. Similar infusions of BDNF into the dorsal raphe nucleus produce an antidepressant effect, as evaluated by several 'learned helplessness'
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Alterations in neurotrophins and neurotrophin receptors in Alzheimer’s disease
2000We demonstrated that nerve growth factor (NGF) levels were increased in hippocampus and cortical areas, as well as in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Such increases may, at least in part, be due to a decreased expression of the NGF high affinity receptor trkA.
Hock CH +6 more
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Current Opinion in Neurobiology, 1994
The neurotrophins act through their signalling competent trk tyrosine kinase receptors (trkA, trkB and trkC), and, in addition, they share a common low-affinity receptor, p75. Acting alone, trk kinases can mediate neurotrophin action, including survival, fiber outgrowth, differentiation and proliferation.
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The neurotrophins act through their signalling competent trk tyrosine kinase receptors (trkA, trkB and trkC), and, in addition, they share a common low-affinity receptor, p75. Acting alone, trk kinases can mediate neurotrophin action, including survival, fiber outgrowth, differentiation and proliferation.
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Acupuncture and Neurotrophin Modulation
2013The Western explanation for acupuncture effectiveness is based upon more than half a century of basic and clinical research, which identified the activation of sensory system and the subsequent activity-dependent regulation of neurotransmitters, neurohormones, and several classes of neuromodulators as plausible mechanism for the acupuncture's ...
SOLIGO, Marzia +4 more
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Neurotrophin and Neurotrophin Receptor Protein Expression in the Human Lung
American Journal of Respiratory Cell and Molecular Biology, 2004Abstract Neurotrophins (NTs) promote survival and differentiation of central and peripheral neurons, and display several activities also in non-neuronal cells. Human lungs synthesize and release NTs, which are probably involved in the pathophysiology of pulmonary disturbances.
RICCI, Alberto +8 more
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Neurotrophins and neurotrophin antagonists as potential therapeutics
Restorative Neurology and Neuroscience, 1995D L, Shelton +3 more
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