Results 91 to 100 of about 58,898 (268)

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

open access: yesIbrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard   +2 more
wiley   +1 more source

p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. [PDF]

open access: yes, 2013
The p75 neurotrophin receptor (p75(NTR)) is a member of the tumor necrosis factor receptor superfamily with a widespread pattern of expression in tissues such as the brain, liver, lung, and muscle.
Akassoglou, Katerina   +7 more
core   +2 more sources

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

open access: yesiMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk   +7 more
wiley   +1 more source

Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice

open access: yesNature Communications, 2019
Neurotrophin-3 (NT-3) plays a key role in the growth, development, and function of the nervous system. Here the authors show that NT-3-induced propriospino-motoneuron circuit reorganization is critical for locomotor recovery in mice following spinal cord
Qi Han   +12 more
doaj   +1 more source

NGF, TrkA-P and neuroprotection after a hypoxic event in the developing central nervous system [PDF]

open access: yes, 2018
A decrease in the concentration of oxygen in the blood and tissues (hypoxia) produces important, sometimes irreversible, damages in the central nervous system (CNS) both during development and also postnatally.
Bogetti, María Eugenia   +4 more
core   +1 more source

Non‐Invasive Brain Stimulation in Chronic Pain: Current Evidence, Network Perspectives and Paths to Personalization

open access: yesSensory Neuroscience, EarlyView.
Chronic pain reflects maladaptive network interactions across sensory, salience/affective, and descending modulatory pathways. We review evidence for non‐invasive brain stimulation—rTMS, tES, and low‐intensity focused ultrasound—highlighting modest, variable, and often short‐lived analgesic effects under conventional protocols.
Fabian Broecker, Sven Vanneste
wiley   +1 more source

Investigating the changes of hippocampal m-RNA gene expression of neurotrophin-3 and its receptor (Tropomyosin Receptor Kinase C) in the recovery of movements of rats with spinal cord injury during two types of endurance exercises [PDF]

open access: yesMedical Laboratory Journal
Background: This study aimed to investigate the effect of four weeks of selected endurance training on neurotrophin-3 (NT-3) and tropomyosin receptor kinase C (TrkC) gene expression in hippocampal areas of rats with spinal cord injury (SCI).
Sina Jalili Rasti   +3 more
doaj  

Polylactic-co-glycolic acid microspheres containing three neurotrophic factors promote sciatic nerve repair after injury

open access: yesNeural Regeneration Research, 2015
A variety of neurotrophic factors have been shown to repair the damaged peripheral nerve. However, in clinical practice, nerve growth factor, neurotrophin-3 and brain-derived neurotrophic factor are all peptides or proteins that may be rapidly ...
Qun Zhao   +7 more
doaj   +1 more source

Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats [PDF]

open access: yes, 2017
The muscarinic receptor response to acetylcholine regulates the hippocampal-related learning, memory, neural plasticity and the production and processing of the pro-nerve growth factor (proNGF) by hippocampal cells.
Berretta, Erica   +9 more
core   +2 more sources

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