Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell +4 more
wiley +1 more source
Cochlear Neurotrophin-3 overexpression at mid-life prevents age-related inner hair cell synaptopathy and slows age-related hearing loss. [PDF]
Aging Cell, 2022 Cassinotti LR +7 more
europepmc +1 more source
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT To support the benefit–risk assessment and dose justification of repotrectinib for patients with c‐ros oncogene 1 (ROS1) positive non‐small cell lung cancer (NSCLC) or neurotrophin receptor tyrosine kinase (NTRK)‐positive solid tumors, exposure–response analyses were conducted.
Shengnan Du +8 more
wiley +1 more source
Serum Levels of Brain-Derived Neurotrophic Factor, Nerve Growth Factor, Neurotrophin-3, and Glial-Derived Neurotrophic Factor in Children with Specific Learning Disorder. [PDF]
Noro Psikiyatr Ars, 2022 Uncu GS +5 more
europepmc +1 more source
Conductive Materials and Electrical Stimulation for Auditory Restoration
Sensory Neuroscience, EarlyView.Applications of electroconductive biomaterials and electrical stimulation in cochlear tissue engineering.(1) Enable auditory neural repair through conductive materials and electrical stimulation, enhancing neuron survival and synaptic plasticity.(2) Integrate optogenetic‐electrical systems and cochlear organoid platforms for frequency‐specific ...
Menghui Liao +8 more
wiley +1 more source
An injectable PEG hydrogel controlling neurotrophin-3 release by affinity peptides. [PDF]
J Control Release, 2021 Wang J +5 more
europepmc +1 more source
Diet transition to a high-fat diet for 3 weeks reduces brain omega-3-fatty acid levels, alters BDNF signaling and induces anxiety & depression-like behavior in adult rats [PDF]
, 2012 Background: The consumption of diets high in calories and low in nutrient value is becoming increasingly common in modern society, which can lead to metabolic disorders like diabetes and obesity, and potentially to psychiatric disorders.
Fernando Gomez-Pinilla +2 more
core +1 more source
Biomaterial‐Based Emergency Intervention for Secondary Spinal Cord Injury
Small Science, EarlyView.Emergency intervention using advanced biomaterials targets key pathological mechanisms to block secondary spinal cord injury (SCI) by inhibiting inflammation, reducing excitotoxicity, restoring the blood−spinal cord barrier, and limiting scar formation, which provides significant neural protection and promotes neural regeneration, offering promising ...
Jincheng Li +5 more
wiley +1 more source
Medical Laboratory Journal, 2020 Background & Objective: Cerebral ischemia causes irreversible structural and functional damages in certain areas of the brain, especially the hippocampus. Evidence indicates that physical exercise may reduce the damages caused by cerebral ischemia.
Mohtaram Yazdanian +3 more
doaj
Combined brain-derived neurotrophic factor and neurotrophin-3 treatment is preferred over either one separately in the preservation of the auditory nerve in deafened guinea pigs. [PDF]
Front Mol Neurosci, 2022 Vink HA +3 more
europepmc +1 more source