Results 171 to 180 of about 58,019 (320)

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

The Role of Brain-Derived Neurotrophic Factor as an Essential Mediator in Neuronal Functions and the Therapeutic Potential of Its Mimetics for Neuroprotection in Neurologic and Psychiatric Disorders

Molecules
Among neurotrophins, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4/5), BDNF has been extensively studied for its physiological role in cell survival and synaptic regulation ...
Tadahiro Numakawa, Ryutaro Kajihara
doaj   +1 more source

Motoneuron-Derived Neurotrophin-3 Is a Survival Factor for PAX2-Expressing Spinal Interneurons [PDF]

, 2002
Catherine Béchade, Catherine Mallecourt, Frédéric Sedel, Sheela Vyas, Antoine Triller   +4 more
openalex   +1 more source

Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision [PDF]

, 2018
Adak, Sangeeta, Chen, Shiming, Doggett, Teresa, Enright, Jennifer, Hsu, Fong-Fu, Ling, Guoyu, Rajagopal, Rithwick, Semenkovich, Clay F, Shah, Vaishali, Wei, Xiaochao, Yoshino, Jun, Zhang, Sheng   +11 more
core   +2 more sources

Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]

, 2008
Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko, Kambe, Yuki, Taniura, Hideo, Yoneda, Yukio   +3 more
core  

The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment

Epilepsia, EarlyView.
Abstract Objective Mutations of the DEP Domain Containing 5 gene (DEPDC5), a mechanistic Target of Rapamycin (mTOR) inhibitor involved in amino acid sensing, are associated with neurological diseases such as epilepsy and/or autism spectrum disorder (ASD). Loss of DEPDC5 impacts early neuronal development via mTOR hyperactivity.
Mattson S. O. Jones, Silvia Lindlar, Johannes Ludwig, Regina Waltes, Afsheen Kumar, Sophie v. Brauchitsch, Andrea Rossi, Evelyn Ullrich, Stefan Momma, Christine M. Freitag, Jasmin K. Hefendehl, Karl Martin Klein, Felix Rosenow, Denise Haslinger, Andreas G. Chiocchetti   +14 more
wiley   +1 more source

A Novel Small Molecule Neurotrophin-3 Analogue Promotes Inner Ear Neurite Outgrowth and Synaptogenesis In vitro. [PDF]

Front Cell Neurosci, 2021
Kempfle JS, Duro MV, Zhang A, Amador CD, Kuang R, Lu R, Kashemirov BA, Edge AS, McKenna CE, Jung DH.   +9 more
europepmc   +1 more source

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

The FEBS Journal, EarlyView.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan, Alexander Rattray, Greg Hutchings, Elizabeth Hay, Chris Murgatroyd, Alasdair MacKenzie   +5 more
wiley   +1 more source

The Overexpression of Insulin-Like Growth Factor-1 and Neurotrophin-3 Promote Functional Recovery and Alleviate Spasticity After Spinal Cord Injury. [PDF]

Front Neurosci, 2022
Talifu Z, Qin C, Xin Z, Chen Y, Liu J, Dangol S, Ma X, Gong H, Pei Z, Yu Y, Li J, Du L.   +11 more
europepmc   +1 more source

753. Neurotrophin-3 Expressed In Situ Induces Axonal Regeneration in the Injured Spinal Cord [PDF]

, 2002

openalex   +1 more source