A Human Neural Tube Model Using 4D Self‐Folding Smart Scaffolds
Induced pluripotent stem cells (iPSCs) exhibit features comparable to the inner cell mass of the human embryo. iPSCs are applied to a novel self‐folding 4D‐Neural Tube (4D‐NT) structure that mimics the neurulation process. This 4D‐NT model recapitulates early events of human neural development and represents a platform to explore neurodevelopmental ...
Claudia Dell'Amico +8 more
wiley +1 more source
Neurotrophin-3 Promotes the Neuronal Differentiation of BMSCs and Improves Cognitive Function in a Rat Model of Alzheimer's Disease. [PDF]
Yan Z, Shi X, Wang H, Si C, Liu Q, Du Y.
europepmc +1 more source
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley +1 more source
Background and Objective: Skeletal muscle expresses several neurotrophin and their receptors which providing the basis for neurotrophin signaling within the muscle compartments.
Eslami R +3 more
doaj
Is There any Possible Role of Neurotrophin 3 in the Pathogenesis of Antrochoanal Polyp? [PDF]
Ozcan C +7 more
europepmc +1 more source
Neurotrophin-3 contributes to benefits of human embryonic stem cell-derived cardiovascular progenitor cells against reperfused myocardial infarction. [PDF]
Bi W +10 more
europepmc +1 more source
Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang +14 more
wiley +1 more source
Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton +12 more
wiley +1 more source
Neurotrophin-3 stimulates stem Leydig cell proliferation during regeneration in rats. [PDF]
Yu Y +12 more
europepmc +1 more source
The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia. [PDF]
Rodrigues-Amorim D +13 more
europepmc +1 more source

