Results 181 to 190 of about 58,898 (268)

NRN1 as a therapeutic target for Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Neuritin‐1 (NRN1) was identified as a synaptic protein associated with cognitive resilience to Alzheimer's disease (AD). METHODS Target risk score and cell type expression profiles were generated for NRN1 using methods developed by the Emory‐Sage‐SGC‐JAX Target Enablement to Accelerate Therapy Development for Alzheimer's Disease ...
Derian A. Pugh, Gregory A. Cary, Kelsey M. Greathouse, Lauren C. Nassour‐Caswell, Emma L. Hobby, Nicholas T. Seyfried, Jeremy H. Herskowitz   +6 more
wiley   +1 more source

Effects of Neurotrophin-3 on Intrinsic Neuronal Properties at a Central Auditory Structure. [PDF]

Neurosci Insights, 2020
Takahashi M, Sanchez JT.
europepmc   +1 more source

Targeted blood proteome profiling using NULISAseq identifies a high‐performance biomarker panel for Aβ pathology quantification and staging

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION While current blood‐based biomarkers for Alzheimer's disease (AD) are effective for determining amyloid beta (Aβ) pathology positivity/negativity, they are insufficient for quantifying Aβ plaque deposition. METHODS We profiled 325 plasma proteins in a Hong Kong Chinese cohort using the Nucleic Acid Linked Immuno‑Sandwich Assay ...
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K. W. Cheng, Elaine Y. L. Cheng, Bonnie W. Y. Wong, Ronnie M. N. Lo, Siu Ki Leung, Fanny C. Ip, Jacqueline K. Y. Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K. Y. Fu, Nancy Y. Ip   +22 more
wiley   +1 more source

Spinal cord stimulation induces Neurotrophin-3 to improve diabetic foot disease. [PDF]

Med Mol Morphol
Liu Y, Li X, Xu H, Sun K, Gong HJ, Luo C.   +5 more
europepmc   +1 more source

Serum Brain-Derived Neurotrophic Factor, Glial-Derived Neurotrophic Factor, Nerve Growth Factor and Neurotrophin-3 Levels in Preschool Children with Language Disorder. [PDF]

Noro Psikiyatr Ars, 2021
Bilgiç A, Ferahkaya H, Kilinç İ, Energin VM.   +3 more
europepmc   +1 more source

Anatolian ground squirrel (Spermophilus xanthoprymnus) retina: Comparative expression of synaptophysin, NeuN, calbindin‐D28k, parvalbumin, glial fibrillary acidic protein, and Iba‐1 during pre‐hibernation and hibernation

The Anatomical Record, Volume 309, Issue 2, Page 451-470, February 2026.
Abstract Hibernation induces significant molecular and cellular adaptations in the retina to maintain function under reduced metabolic conditions. This study aimed to investigate the expression of neuronal, synaptic, and glial markers in the retina of Spermophilus xanthoprymnus during pre‐hibernation and hibernation periods using immunohistochemical ...
Mehmet Özbek, Feyzullah Beyaz, Mustafa Öztop, Harun Karaca, Ahmet Cabir, Begüm Fatma Kiryar   +5 more
wiley   +1 more source

Safe subdural administration and retention of a neurotrophin-3-delivering hydrogel in a rat model of spinal cord injury. [PDF]

Sci Rep
Meissner S, Lopez S, Rees S, O'Carroll S, Barker D, Harland B, Raos B, Svirskis D.   +7 more
europepmc   +1 more source

AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 273-286, February 2026.
ABSTRACT Adeno‐associated virus (AAV) is a promising delivery system for gene therapy. However, current manufacturing of AAV suffers from very low yields compared to other biotherapeutics. The AAV dose per patient ranges between 1011and 1015 viral genomes (vg), requiring an average of 10 to 30 L production/dose.
Alaka Mullick, Audrey Morasse, Melanie Leclerc, Ziying Liu, Qing Yan Liu, Sonia Leclerc, Milica Momcilovic, Annie Viau, Amine A. Kamen   +8 more
wiley   +1 more source

Modifications in the C-terminal tail of TrkC significantly alter neurotrophin-3-promoted outgrowth of neurite-like processes from PC12 cells. [PDF]

Biochem Biophys Rep
Krawczyk P, Klopotowska D, Matuszyk J.
europepmc   +1 more source

The Impact of Moderate to High Intensity Physical Activity on Sleep Health in Cancer Survivors

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Sleep disturbances are common among cancer survivors and negatively impact quality of life. Regular moderate‐ to high‐intensity physical activity may provide a cost‐effective, low‐risk alternative strategy to improve sleep. Methods Data collected as part of two distinct studies, the Detroit Research On Cancer Survivors (ROCS) cohort
Grace E. Markey, Julie J. Ruterbusch, Tara E. Baird, Jennifer L. Martin, Ann G. Schwartz, David G. Finlay, Trey Timban, Matthew R. Trendowski, M. Safwan Badr, Kerri Winters‐Stone, Jennifer L. Beebe‐Dimmer   +10 more
wiley   +1 more source