Results 301 to 310 of about 58,019 (320)
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Experimental Brain Research, 2010
In this study, we investigated the hypothesis whether neurotrophins have a differential influence on neurite growth from the entorhinal cortex depending on the presence or absence of hippocampal target tissue. We investigated organotypic brain slices derived from the entorhinal-hippocampal system to analyze the effects of endogenous and recombinant ...
Daniel Hechler +4 more
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In this study, we investigated the hypothesis whether neurotrophins have a differential influence on neurite growth from the entorhinal cortex depending on the presence or absence of hippocampal target tissue. We investigated organotypic brain slices derived from the entorhinal-hippocampal system to analyze the effects of endogenous and recombinant ...
Daniel Hechler +4 more
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Sensory ganglia require neurotrophin-3 early in development [PDF]
Development, 1994 ABSTRACT The role played by neurotrophin-3 during the development of quail sensory ganglia was investigated using a mono-clonal antibody that specifically blocks the biological activity of this neurotrophin. Neutralisation of neu-rotrophin-3 was initiated during completion of gangliogen-esis.
Gaese, F., Kolbeck, R., Barde, Y. A.
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Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Science, 1990The development and maintenance of the nervous system depends on proteins known as neurotrophic factors. Although the prototypical neurotrophic factor, nerve growth factor (NGF), has been intensively studied for decades, the discovery and characterization of additional such factors has been impeded by their low abundance.
Maisonpierre, P.C. +6 more
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Neuroscience, 1998
The neurotrophin family of trophic factors influences survival and function of neurons in both the peripheral and central nervous systems. Critical information regarding physiological function of these factors may be gained by examining their localization in the brain.
Wilma J. Friedman +2 more
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The neurotrophin family of trophic factors influences survival and function of neurons in both the peripheral and central nervous systems. Critical information regarding physiological function of these factors may be gained by examining their localization in the brain.
Wilma J. Friedman +2 more
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Apoptosis of Merkel cells in neurotrophin-3 null mice
Anatomy and Embryology, 2005Postnatal mice lacking neurotrophin-3 (NT3) are deficient in Merkel cells of touch domes and whisker follicles. We examined the mechanism of Merkel cell loss by immunocytochemistry and electron microscopy. Merkel cell of whisker follicles of NT3 null newborns exhibited decreased immunoreactivity for cytokeratin 8 and contained apoptotic bodies that ...
Milos Grim +3 more
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Dependence of developing group Ia afferents on neurotrophin‐3
Journal of Comparative Neurology, 1995AbstractAt birth, group Ia proprioceptive afferents and muscle spindles, whose formation is Ia afferent‐dependent, are absent in mice carrying a deletion in the gene for neurotrophin‐3 (NT‐3 –/–). Whether Ia afferents contact myotubes, resulting in the formation of spindles which subsequently degenerate, or whether Ia afferents and spindles never form ...
Jan Kucera +6 more
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Neurotrophin-3 as an essential signal for the developing nervous system [PDF]
Molecular Neurobiology, 1996 Rapid advances in characterization of the biological actions mediated by the third member of the neurotrophin family, neurotrophin-3 (NT-3), have been made recently in vitro as well as in situ. These have been made possible by the cloning of the genes for NT-3 and for its transducing receptor tyrosine kinase TrkC.
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Neuroscience, 2007
In the months following transection of adult rat peripheral nerve some sensory neurons undergo apoptosis. Two weeks after sciatic nerve transection some neurons in the L4 and L5 dorsal root ganglia begin to show immunoreactivity for nestin, a filament protein expressed by neuronal precursors and immature neurons, which is stimulated by neurotrophin-3 ...
Kuo, L T +4 more
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In the months following transection of adult rat peripheral nerve some sensory neurons undergo apoptosis. Two weeks after sciatic nerve transection some neurons in the L4 and L5 dorsal root ganglia begin to show immunoreactivity for nestin, a filament protein expressed by neuronal precursors and immature neurons, which is stimulated by neurotrophin-3 ...
Kuo, L T +4 more
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Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex
Nature, 2008Neurotrophins (NTs) are important regulators for the survival, differentiation and maintenance of different peripheral and central neurons. NTs bind to two distinct classes of glycosylated receptor: the p75 neurotrophin receptor (p75(NTR)) and tyrosine kinase receptors (Trks). Whereas p75(NTR) binds to all NTs, the Trk subtypes are specific for each NT.
Hong-jun Yu +3 more
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Chapter 14 Neurotrophin—3 and Maintenance of Muscle Afferent Function
1999Publisher Summary Axotomizing peripheral cutaneous and muscle nerves and thus depriving them of contact with their peripheral targets result in slowed conduction of their action potentials. Reinnervation of their peripheral targets results in the recovery of conduction velocity.
John B. Munson +2 more
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