Results 31 to 40 of about 58,019 (320)
eLife, 2016 Brain and spinal injury reduce mobility and often impair sensorimotor processing in the spinal cord leading to spasticity. Here, we establish that complete transection of corticospinal pathways in the pyramids impairs locomotion and leads to increased ...
Claudia Kathe +3 more
doaj +1 more source
Involvement of ras p2I in Neurotrophin-induced Response of Sensory, but Not Sympathetic Neurons [PDF]
, 1993 Little is known about the signal transduction mechanisms involved in the response to neurotrophins and other neurotrophic factors in neurons, beyond the activation of the tyrosine kinase activity of the neurotrophin receptors belonging to the trk family.
Barde, Y. A. +4 more
core +3 more sources
Neurotrophin-3 signals redistribute RNA in neurons [PDF]
Proceedings of the National Academy of Sciences, 1997 The translocation of specific mRNAs to dendrites and their potential for locally regulated translation are likely to serve as an effector in neuronal plasticity. Whether translation in dendrites is regulated by delivery of the RNA to sites of plasticity or a stationary pool of localized RNA undergoes enhanced translational efficiency is not clear.
Kenneth S. Kosik, Roger B. Knowles
openaire +3 more sources
Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs [PDF]
Exploration of Drug ScienceProteins from the neurotrophin family perform trophic and regulatory functions in the nervous and other body systems. Understanding the mechanisms of neurotrophin action is crucial not only for the evolution of fundamental scientific knowledge but also ...
Tatiana Gudasheva +2 more
doaj +1 more source
Inducers of epithelial mesenchymal transition and cancer stem cells in malignant pleural effusions [PDF]
, 2016 The Epithelial to Mesenchymal Transition (EMT) plays a role not only in tumor metastasis but also in tumor recurrence. This process is believed to be tightly linked to the presence of Cancer Stem Cells (CSCs) however, it is still not clear which ...
Cherubini, Emanuela +5 more
core +1 more source
Frontiers in Cellular Neuroscience, 2014 BDNF and nitric oxide signaling both contribute to plasticity at glutamatergic synapses. However the role of combined signaling of both pathways at the same synapse is largely unknown.
Richard eKolarow +9 more
doaj +1 more source
Neurotrophin-3 Involvement in the Regulation of Hair Follicle Morphogenesis [PDF]
Journal of Investigative Dermatology, 1998 Hair follicle epithelium and nervous system share a common ectodermal origin, and some neurotrophins can modulate keratinocyte proliferation and apoptosis. It is therefore reasonable to ask whether growth factors that control neural development are also involved in the regulation of hair follicle morphogenesis. Focusing on neurotrophin-3 (NT-3) and its
Ralf Paus +5 more
openaire +3 more sources
Data in Brief, 2018 Unilateral or bilateral corticospinal tract injury in the medullary pyramids in adult rats causes anatomical and physiological changes in proprioceptive neurons projecting to the cervical spinal cord accompanied by hyperreflexia and abnormal behavioural ...
Claudia Kathe, Lawrence D.F. Moon
doaj +1 more source
Training-induced gene expression plasticity in cardiac function and neural regulation for ultra-trail runners [PDF]
, 2015 This study aims to assess the gene regulatory response from a group of 16 athletes and to observe the plasticity induced by their training regime on the gene expression response after their participation in an 82km race.
Brotons, Daniel +4 more
core +1 more source
Frontiers in Aging Neuroscience, 2017 Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. The accumulation of Aβ in the brain is thought to play a causative role in the development of cognitive dysfunction in Alzheimer's disease.
Li An +9 more
doaj +1 more source