Preclinical Models: Boosting Synergies for Improved Translation [PDF]
The field of preclinical models is a very vast arena, in which finding connections among groups acting in apparently very distant research areas can sometimes prove challenging [...
Attanasio C., Sangiovanni M.
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Unilateral or bilateral corticospinal tract injury in the medullary pyramids in adult rats causes anatomical and physiological changes in proprioceptive neurons projecting to the cervical spinal cord accompanied by hyperreflexia and abnormal behavioural ...
Claudia Kathe, Lawrence D.F. Moon
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Alzheimer's disease is an irreversible, progressive neurodegenerative disorder. The accumulation of Aβ in the brain is thought to play a causative role in the development of cognitive dysfunction in Alzheimer's disease.
Li An +9 more
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Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]
The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA +2 more
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Training-induced gene expression plasticity in cardiac function and neural regulation for ultra-trail runners [PDF]
This study aims to assess the gene regulatory response from a group of 16 athletes and to observe the plasticity induced by their training regime on the gene expression response after their participation in an 82km race.
Brotons, Daniel +4 more
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Serum neurotrophin-3 and neurotrophin-4 levels are associated with asthma severity in children [PDF]
To the Editors: Asthma is the most common chronic disease in childhood and is characterised by chronic airway inflammation, reversible airflow obstruction and hyperresponsiveness of the airways. Among the substantial pathophysiological aspects of asthma are neuroimmune interaction mechanisms; neurotrophins are mediators of the interactions providing ...
A, Szczepankiewicz +7 more
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The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing [PDF]
AIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues.
Abban, G. +6 more
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Crystallization and preliminary structural studies of neurotrophin‐3 [PDF]
AbstractNeurotrophin‐3 (NT‐3) has been crystallized in 2 forms. Orthorhombic crystals, space group P21212, diffracted to 2.8 Å and have cell dimensions a = 39.1 Å, b = 54.0 Å, and c = 65.5 Å. The second form is space group P43212, with cell dimensions a = b = 67.1 Å, and c = 107.9 Å. The tetragonal crystals diffract to 2.8 Å at room temperature and 2.5
J A, Kelly +3 more
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High abundances of neurotrophin 3 in atopic dermatitis mast cell
Background Neurotrophin 3 (NT-3) is a member of the neurotrophin family, a group of related proteins that are known to regulate neuro-immune interactions in allergic diseases.
Groneberg David A +4 more
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Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples [PDF]
Emerging evidence has shown that the tumor microenvironment plays a crucial role in prostate cancer (PCa) development and progression. However, the mechanism(s) through which stromal cells regulate epithelial cells and the differences among prostatic ...
Clemente, Luigi Di +7 more
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